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公开(公告)号：US20100022011A1
公开(公告)日：2010-01-28
申请号：US11581777
申请日：2006-10-16
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其它化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US20080248578A1
公开(公告)日：2008-10-09
申请号：US11784208
申请日：2007-04-05
CPC分类号： G01N21/76 , C07D471/14 , G01N21/643 , G01N21/783 , G01N33/0057 , G01N2021/7786 , G01N2201/0221 , Y10T436/10 , Y10T436/20 , Y10T436/206664
摘要： The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
摘要翻译： 本发明提供了一系列与爆炸物的测定相关的系统，装置和方法，例如过氧化物或过氧化物前体以及其他物质。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。
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13.发明授权公开(公告)号：US07399488B2
公开(公告)日：2008-07-15
申请号：US10614866
申请日：2003-07-07
申请人： Jane Hirsh , Alexander M. Kibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison B. Fleming , Roman V. Rariy
发明人： Jane Hirsh , Alexander M. Kibanov , Timothy M. Swager , Stephen L. Buchwald , Whe Yong Lo , Alison B. Fleming , Roman V. Rariy
CPC分类号： A61K31/485 , A61K9/145 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/4858 , A61K9/50 , A61K9/5052 , A61K9/5084 , A61K31/20 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
摘要翻译： 已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是诸如阿片类药物。 在优选的实施方案中，修饰药物以增加其亲油性。 在优选实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的微粒内。 在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一个涂层是水不溶性的，优选有机溶剂不溶，但是通过存在于人胃肠道中的酶可酶促降解。 即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。 然而，当按照指导给药时，由于组合物通过酶降解，胆汁酸的表面活性作用和机械侵蚀的组合被分解或逐渐溶解在胃肠道内，药物从组合物中缓慢释放。
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14.发明申请公开(公告)号：US20080102386A1
公开(公告)日：2008-05-01
申请号：US11641125
申请日：2006-12-18
IPC分类号： G03C1/00 , C08F210/00 , C08F210/14 , G02F1/03
CPC分类号： C09K19/542 , C08G81/00 , C08G2261/148 , C08G2261/3422 , C08L65/00 , C08L101/12 , G02F2001/13345
摘要： The present invention provides compositions, devices and methods related to the alignment of materials including polymers. In some cases, the present invention comprises the assembly of molecules (e.g., polymers) via intermolecular interactions to produce extended networks, which may have enhanced properties relative to the individual molecules. Such networks may be advantageous for use in electronics, photovoltaics, sensor applications, and the like. In some embodiments, the present invention may enhance the performance of certain optical devices, such as liquid crystal displays (e.g., color liquid crystal displays) by providing enhanced contrast ratio, faster response times, and/or lower operating voltage.
摘要翻译： 本发明提供了与包括聚合物在内的材料对准相关的组合物，装置和方法。 在一些情况下，本发明包括通过分子间相互作用组装分子（例如聚合物）以产生延伸网络，其可以相对于各个分子具有增强的性质。 这样的网络可能有利于用于电子，光伏，传感器应用等。 在一些实施例中，本发明可以通过提供增强的对比度，更快的响应时间和/或更低的工作电压来增强某些光学装置的性能，例如液晶显示器（例如彩色液晶显示器）。
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公开(公告)号：US07041910B2
公开(公告)日：2006-05-09
申请号：US10621041
申请日：2003-07-15
申请人： Timothy M. Swager , Steffen Zahn
发明人： Timothy M. Swager , Steffen Zahn
IPC分类号： H01B7/00
CPC分类号： C09K11/06 , C08G61/02 , C09K9/02 , C09K2211/1416 , C09K2211/1425 , H01L51/0035 , H01L51/0043 , H01L51/0052 , H01L51/42 , H01L51/50 , Y02E10/549
摘要： The present invention generally relates to stable emissive aggregates of polymers. The aggregates are composed of various polymer molecules arranged in such a way as to allow extended electronic couplings between nearby polymer molecules, enhancing exciton transport, while minimizing the effects of quenching due to interchain interactions. For example, the polymer molecules may be arranged in a non-aligned, electronically-communicative manner (for example, at an oblique angle), stabilized by various methods such as chemical linkages or physical interactions. Within the aggregate, electronic interactions along the polymer molecule may extend to nearby polymer molecules, which may be observed as a shift in the absorption spectra relative to a random dispersion. Light emitted from the aggregate may be polarized in some cases, for example, linearly or circularly, which may be caused by chiral arrangements of polymers within the aggregate (the polymers themselves may or may not be chiral). These aggregates may find widespread use, for example, in enantiomeric detectors, electrochemical devices, photodetectors, organic diodes, sensors, light sources, or photovoltaic devices.
摘要翻译： 本发明一般涉及聚合物的稳定发射聚集体。 聚集体由各种聚合物分子组成，这些聚合物分子以允许附近聚合物分子之间的扩展电子耦合方式排列，增强激子传输，同时最小化由于链间相互作用引起的猝灭的影响。 例如，聚合物分子可以以不对准的电子通信方式（例如，以倾斜角度）排列，通过诸如化学键或物理相互作用的各种方法来稳定。 在聚合物中，沿着聚合物分子的电子相互作用可以延伸到附近的聚合物分子，这可以作为相对于随机分散体的吸收光谱的偏移而被观察到。 从聚集体发射的光可能在某些情况下极化，例如线性或圆形，这可能由聚合物内的聚合物的手性排列引起（聚合物本身可能是或可能不是手性的）。 这些聚集体可以广泛用于例如对映体检测器，电化学装置，光电检测器，有机二极管，传感器，光源或光伏器件中。
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16.发明授权Calixarene-based transition metal complexes and photonic devices comprising the same 失效基于杯芳烃的过渡金属络合物和包含它们的光子器件
公开(公告)号：US5453220A
公开(公告)日：1995-09-26
申请号：US11301
申请日：1993-01-29
申请人： Timothy M. Swager , Bing Xu
发明人： Timothy M. Swager , Bing Xu
IPC分类号： C07C205/37 , C07C245/08 , F21V9/00
CPC分类号： C07C205/37 , C07C245/08 , C07C2103/92
摘要： Calixarene-based, noncentrosymmetric transition metal complexes that exhibit large second order nonlinear optical and related electro-optical properties are provided, as are materials and devices comprising the same.
摘要翻译： 提供了表现出大二阶非线性光学和相关电光学性质的基于杯芳烃的非对称过渡金属络合物，以及包括其的材料和器件。
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公开(公告)号：US20110190457A1
公开(公告)日：2011-08-04
申请号：US12529939
申请日：2008-03-07
CPC分类号： C08G64/06 , C08G64/183 , C08G65/40 , C08G75/23 , C08G79/04 , C08L69/00 , C08L71/00 , C08L75/00 , C08L81/00 , C08L81/06 , C08L2205/05 , C08L2666/14
摘要： The present invention relates to polymeric materials having enhanced properties. In some cases, the materials may comprise polymers having shape-persistent portions which may enhance the mechanical properties of the material. The materials may exhibit higher stiffness or strength and ductility values, resulting in higher energy absorption and enhanced protection, as well as longer lifetimes for product usage. In some cases, the materials may be optically transparent and lightweight, making them suitable for in various applications including protective materials.
摘要翻译： 本发明涉及具有增强性能的聚合物材料。 在一些情况下，材料可以包括具有形状持久性部分的聚合物，其可以增强材料的机械性能。 材料可能表现出更高的刚度或强度和延展性值，从而导致更高的能量吸收和增强的保护，以及更长的产品使用寿命。 在某些情况下，材料可以是光学透明的和轻质的，使得它们适用于各种应用，包括保护材料。
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18.发明申请公开(公告)号：US20110171629A1
公开(公告)日：2011-07-14
申请号：US12939539
申请日：2010-11-04
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/54353 , G01N33/54366 , Y10T436/143333
摘要： The present invention provides compositions and devices comprising nanostructure networks, and related methods. The compositions may exhibit enhanced interaction between nanostructures, providing improved device performance (e.g., improved conductivity). In some embodiments, the devices are capable of interacting with various species to produce an observable signal from the device. In some cases, the compositions and devices may be useful in the determination of analytes, including—biological analytes (e.g., DNA, ebola virus, other infective agents, etc.), small, organic analytes, and the like. The embodiments described herein may exhibit high sensitivity and specificity to analytes and may be capable of analyte detection at femtomolar concentrations (e.g., 10 fM).
摘要翻译： 本发明提供了包含纳米结构网络的组合物和装置以及相关方法。 组合物可以表现出增强的纳米结构之间的相互作用，提供改进的器件性能（例如改善的导电性）。 在一些实施例中，装置能够与各种物质相互作用以从装置产生可观察到的信号。 在一些情况下，组合物和装置可用于测定分析物，包括生物分析物（例如DNA，埃博拉病毒，其他感染剂等），小的有机分析物等。 本文描述的实施方案可以对分析物显示出高灵敏度和特异性，并且可能能够在飞摩尔浓度（例如，10fM）下进行分析物检测。
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公开(公告)号：US07862775B2
公开(公告)日：2011-01-04
申请号：US12693868
申请日：2010-01-26
IPC分类号： G01N21/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US07799573B2
公开(公告)日：2010-09-21
申请号：US11784208
申请日：2007-04-05
IPC分类号： G01N33/00
CPC分类号： G01N21/76 , C07D471/14 , G01N21/643 , G01N21/783 , G01N33/0057 , G01N2021/7786 , G01N2201/0221 , Y10T436/10 , Y10T436/20 , Y10T436/206664
摘要： The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
摘要翻译： 本发明提供了一系列与爆炸物的测定相关的系统，装置和方法，例如过氧化物或过氧化物前体以及其他物质。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。
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