公开(公告)号：US20190209548A1

公开(公告)日：2019-07-11

申请号：US16195342

申请日：2018-11-19

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore

发明人： Herman O. Sintim ,  Jie Zhou ,  Changhao Wang ,  Rena Lapidus

IPC分类号： A61K31/472 ,  C07D471/04 ,  A61K31/4725 ,  C07D413/12 ,  C07C245/24 ,  C07D217/22 ,  C07C257/18 ,  C07D417/12 ,  C07D401/12 ,  C07D401/04 ,  C07C279/18

CPC分类号： A61K31/472 ,  A61K31/4725 ,  C07C245/24 ,  C07C257/18 ,  C07C279/18 ,  C07D217/22 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.

公开(公告)号：US10179145B2

公开(公告)日：2019-01-15

申请号：US15001215

申请日：2016-01-19

申请人： University of Maryland, Baltimore ,  University of Maryland, College Park

发明人： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC分类号： A61K31/722 ,  A61K47/56 ,  A61K47/61 ,  A61L27/20 ,  A61L26/00 ,  A61K9/127 ,  A61K9/70 ,  A61K47/69

摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

公开(公告)号：US20160206777A1

公开(公告)日：2016-07-21

申请号：US15001215

申请日：2016-01-19

申请人： University of Maryland, Baltimore ,  University of Maryland, College Park

发明人： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC分类号： A61L26/00

CPC分类号： A61K31/722 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/7007 ,  A61K47/56 ,  A61K47/61 ,  A61K47/69 ,  A61L26/0023 ,  A61L27/20 ,  A61L2300/216 ,  A61L2300/232 ,  A61L2300/418 ,  A61L2300/626 ,  A61L2400/04 ,  A61L2400/12 ,  C08L5/08

摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

公开(公告)号：US20130218005A1

公开(公告)日：2013-08-22

申请号：US13763284

申请日：2013-02-08

申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK ,  UNIVERSITY OF MARYLAND, BALTIMORE

发明人： JAYDEV P. DESAI ,  MINGYEN HO ,  J. MARC SIMARD ,  RAO GULLAPALLI

IPC分类号： A61B19/00 ,  A61M1/00 ,  A61B18/12 ,  A61B18/04 ,  A61B8/08 ,  A61N7/00 ,  A61B5/055 ,  A61B5/06 ,  A61B6/03 ,  A61B17/00 ,  A61B18/20

CPC分类号： A61B6/032 ,  A61B5/055 ,  A61B5/062 ,  A61B6/12 ,  A61B8/0841 ,  A61B17/00234 ,  A61B18/042 ,  A61B18/12 ,  A61B18/1492 ,  A61B18/20 ,  A61B34/20 ,  A61B34/30 ,  A61B2017/00477 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2034/2051 ,  A61B2034/306 ,  A61B2034/715 ,  A61M1/0058 ,  A61N7/00 ,  A61N7/022

摘要： Minimally invasive neurosurgical intracranial robot system is introduced to the operative site by a neurosurgeon through a narrow surgical corridor. The robot is passed through a cannula and is attached to the cannula by a latching mechanism. The robot has several links interconnected via revolute joints which are tendon-driven by tendons routed through channels formed in the walls of the links. The robot is teleoperatively guided by the neurosurgeon based on real-time images of the intracranial operative site and tracking information of the robot position. The robot body is equipped with a tracking system, tissue liquefacting end-effector, at as well as irrigation and suction tubes. Actuators for the tendon-driven mechanism are positioned at a distance from the imaging system to minimize distortion to the images. The tendon-actuated navigation of the robot permits an independent control of the revolute joints in the robot body.

摘要翻译： 微创神经外科颅内机器人系统由神经外科医生通过狭窄的手术走廊引入手术部位。 机器人穿过套管并通过闭锁机构附接到套管。 机器人具有通过旋转接头相互连接的多个连杆，其由通过形成在链节壁中的通道布置的腱驱动。 机器人由神经外科医生根据颅内手术部位的实时图像和机器人位置的跟踪信息进行远程导引。 机器人身体配备有跟踪系统，组织液化终端执行器，以及灌溉和抽吸管。 用于腱驱动机构的致动器位于离成像系统一定距离处，以最小化图像的失真。 机器人的肌腱导向导航可以独立控制机器人体内的旋转关节。

公开(公告)号：US20130197271A1

公开(公告)日：2013-08-01

申请号：US13752482

申请日：2013-01-29

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF MARYLAND, COLLEGE PARK

发明人： YIHUA (BRUCE) YU ,  XUYI YUE

IPC分类号： C07C323/12 ,  A61K51/06

CPC分类号： C07C323/12 ,  A61K49/124 ,  A61K51/06

摘要： The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.

摘要翻译： 本发明提供了具有核心，分支和周边末端的单分散树枝状大分子，其中分支数目从核心到周边端呈指数级增加，并且分支的长度从周边端到核心指数地增加，从而提供附着 的化学物质在周边端部没有表现出空间位阻。

公开(公告)号：US20230235029A1

公开(公告)日：2023-07-27

申请号：US18016930

申请日：2021-07-20

申请人： Integrated Biotherapeutics, Inc. ,  University of Maryland, College Park ,  University of Maryland, Baltimore ,  La Jolla Institute for Immunology

发明人： Mohammad Javad Aman ,  Yimeng Wang ,  Shweta Kailasan ,  Xuelian Zhao ,  Andrey Galkin ,  Katie A. Howell ,  Erica Ollmann Saphire ,  Yuxing Li

IPC分类号： C07K16/10 ,  A61P31/14 ,  G01N33/569 ,  G01N33/543

CPC分类号： C07K16/10 ,  A61P31/14 ,  G01N33/56983 ,  G01N33/54386 ,  A61K39/00

摘要： Disclosed herein is a novel class of isolated binding molecules including monoclonal antibodies that targets a broadly conserved epitope within the marburgvirus species. Certain aspects provide an effective treatment option for hemorrhagic fever caused by marburgviruses.

公开(公告)号：US20220250147A1

公开(公告)日：2022-08-11

申请号：US17683844

申请日：2022-03-01

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore

发明人： Zhihong NIE ,  Radi MASRI

IPC分类号： B22F9/24 ,  A61K41/00 ,  A61K47/69 ,  A61C8/00 ,  B22F1/16 ,  B22F1/054

摘要： Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.

公开(公告)号：US11285539B2

公开(公告)日：2022-03-29

申请号：US16300299

申请日：2017-05-12

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore

发明人： Zhihong Nie ,  Radi Masri

IPC分类号： B22F9/24 ,  B22F1/02 ,  A61K41/00 ,  B22F1/00 ,  A61K47/69 ,  A61C8/00 ,  A61C13/083

摘要： Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.

公开(公告)号：US20210388454A1

公开(公告)日：2021-12-16

申请号：US17325839

申请日：2021-05-20

申请人： University of Maryland, Baltimore ,  University of Maryland, Baltimore County

发明人： DIPANJAN PAN ,  PARIKSHIT MOITRA ,  MAHA MOHAMMAD SHEHADEH ALAFEEF ,  KETAN DIGHE

IPC分类号： C12Q1/70

摘要： The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens.

公开(公告)号：US10711043B2

公开(公告)日：2020-07-14

申请号：US16030506

申请日：2018-07-09

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore

发明人： Philip R. DeShong ,  Lenea Stocker ,  Daniel C. Stein ,  Stefanie N. Vogel ,  Katharina Richard

IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K49/00 ,  C07K14/195 ,  C07K14/22 ,  A61K39/39 ,  A61K39/00

摘要： The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are useful to stimulate an antigen-specific immune response and, in some embodiments, a protective immune response in an animal after challenge to pathogens. The compositions of the disclosure are also useful for treatment and prevention of disease in a subject such as cancer.