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公开(公告)号：US09132190B2
公开(公告)日：2015-09-15
申请号：US14090778
申请日：2013-11-26
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
Abstract translation: 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：US20140079705A1
公开(公告)日：2014-03-20
申请号：US14082502
申请日：2013-11-18
Applicant: Abbvie Inc.
Inventor： Chung-ming Hsieh , Jennifer Perez , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Suju Zhong , Lucia Eaton , Margaret Hugunin , Alyssa Brito , Anca Clabbers
CPC classification number: A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/241 , C07K16/244 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/5308
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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公开(公告)号：US20200338209A1
公开(公告)日：2020-10-29
申请号：US16308742
申请日：2017-06-07
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Milan Bruncko , Debra Chao , Kamel Izeradjene , Andrew S. Judd , Andrew C. Phillips , Andrew J. Souers , Archana Thakur
Abstract: The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20200147235A1
公开(公告)日：2020-05-14
申请号：US16308774
申请日：2017-06-08
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Milan Bruncko , Andrew S. Judd , Yingchun Li , Andrew Mccluskey , Andrew C. Phillips , Darren C. Phillips , Jane Seagal , Andrew J. Souers
IPC: A61K47/68 , A61K31/337 , C07K16/28
Abstract: The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US10098968B2
公开(公告)日：2018-10-16
申请号：US15808419
申请日：2017-11-09
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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Patent Agency Ranking
16.发明授权公开(公告)号：US09915665B2
公开(公告)日：2018-03-13
申请号：US14141498
申请日：2013-12-27
Applicant: AbbVie, Inc.
Inventor： Lorenzo Benatuil , Jennifer Perez , Chung-Ming Hsieh
IPC: G01N33/68 , C40B20/04 , C40B30/04 , C07K16/46 , C12N15/10 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24
CPC classification number: G01N33/6854 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/245 , C07K16/468 , C07K2317/64 , C07K2317/92 , C12N15/1037 , C40B20/04 , C40B30/04
Abstract: System and methods are disclosed for identifying and isolating antibodies with specific affinity with an antigen of interest. Multiple DNA libraries encoding antibodies or their fragments are designed such that the encoded antibodies from different libraries are tagged differently. These libraries may be transformed into yeast cells. The variants of the antibodies are displayed on the surface of the yeast cells and flow cytometry may be used to sort the cells based on antigen affinity and the different tags on the antibodies. By allowing multiple libraries to be screened simultaneously, the disclosed methods help improve the efficiency of affinity.
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公开(公告)号：US09840554B2
公开(公告)日：2017-12-12
申请号：US15183725
申请日：2016-06-15
Applicant: ABBVIE INC.
Inventor： Jijie Gu , Diana Bowley , Lucia Eaton , Feng Dong , Lorenzo Benatuil , Tariq Ghayur , Ravi Chari , Matthew Rieser , Anca Clabbers
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.
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公开(公告)号：US09827330B2
公开(公告)日：2017-11-28
申请号：US15349692
申请日：2016-11-11
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US09822171B2
公开(公告)日：2017-11-21
申请号：US14618632
申请日：2015-02-10
Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
Inventor： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
CPC classification number: C07K16/18 , A61K39/3955 , A61K47/6835 , A61K49/00 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/92
Abstract: The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
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公开(公告)号：US09458244B2
公开(公告)日：2016-10-04
申请号：US14141500
申请日：2013-12-27
Applicant: AbbVie, Inc.
Inventor： Lorenzo Benatuil , Chung-Ming Hsieh
CPC classification number: C07K16/245 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/468 , C07K2317/35 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C12N15/1082 , C40B40/10
Abstract: Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the screening of single chain multivalent binding proteins using cell surface display technology (e.g., yeast display).
Abstract translation: 提供单链多价结合蛋白（例如scDVD和scDVDFab分子）的蛋白质，核酸和细胞文库以及使用这些文库用于使用细胞表面显示技术筛选单链多价结合蛋白的方法（例如，酵母 显示）。
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