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公开(公告)号：US12077750B2
公开(公告)日：2024-09-03
申请号：US16812225
申请日：2020-03-06
Inventor： Jinglin Fu , Zhao Zhao , Neal Woodbury , Hao Yan
Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
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公开(公告)号：US20230374607A1
公开(公告)日：2023-11-23
申请号：US18298922
申请日：2023-04-11
Inventor： Hao Yan , Rizal Hariadi , Swarup Dey
IPC: C12Q1/6886 , C12Q1/6818 , C12Q1/6804
CPC classification number: C12Q1/6886 , C12Q1/6818 , C12Q2600/178 , C12Q1/6804
Abstract: Disclosed herein is a transmembrane nanosensor device comprising a lipid conjugated DNA tweezer, and methods of using the same.
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公开(公告)号：US20220372586A1
公开(公告)日：2022-11-24
申请号：US17879871
申请日：2022-08-03
Inventor： Alexander Green , Fan Hong , Soma Chaudhary , Anli Tang , Hao Yan
IPC: C12Q1/6897 , C12Q1/6858
Abstract: Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva.
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公开(公告)号：US11254941B2
公开(公告)日：2022-02-22
申请号：US16642792
申请日：2018-08-30
Inventor： Hao Yan , Yung Chang , Xiaowei Liu , Fei Zhang , Xiaodong Qi
IPC: C12N15/117 , B82Y5/00
Abstract: Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).
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公开(公告)号：US11242533B2
公开(公告)日：2022-02-08
申请号：US16954458
申请日：2019-01-10
Inventor： Yung Chang , Hao Yan , Xiaodong Qi , Fei Zhang
IPC: C12N15/117 , B82Y5/00 , A61K38/00 , A61K39/00
Abstract: Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.
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Patent Agency Ranking
公开(公告)号：US10189874B2
公开(公告)日：2019-01-29
申请号：US15121007
申请日：2015-02-25
Inventor： Dongran Han , Hao Yan
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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17.发明申请公开(公告)号：US20240409669A1
公开(公告)日：2024-12-12
申请号：US18701901
申请日：2022-10-20
Inventor： Nicholas Stephanopoulos , Yang Xu , Petr Sulc , Hao Yan , Rong Zheng , Abhay Prasad
IPC: C07K19/00 , A61K38/00 , A61P31/14 , C07K14/005
Abstract: The present disclosure relates to DNA-peptide hybrid molecules. In some embodiments, the DNA-peptide hybrid molecules comprise target-specific binding peptides which selectively bind to SARS-COV-2 surface glycoprotein. Methods of using DNA-peptide hybrid molecules in the treatment of SARS-COV-2 infection are also provided.
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公开(公告)号：US11434540B2
公开(公告)日：2022-09-06
申请号：US16349752
申请日：2017-11-15
Inventor： Alexander Green , Fan Hong , Soma Chaudhary , Anli Tang , Hao Yan
IPC: C12Q1/6858 , C12Q1/6897
Abstract: Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva.
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公开(公告)号：US10669534B2
公开(公告)日：2020-06-02
申请号：US15649351
申请日：2017-07-13
Inventor： Jinglin Fu , Zhao Zhao , Neal Woodbury , Hao Yan
Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
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公开(公告)号：US20200071777A1
公开(公告)日：2020-03-05
申请号：US16349752
申请日：2017-11-15
Inventor： Alexander Green , Fan Hong , Soma Chaudhary , Anli Tang , Hao Yan
IPC: C12Q1/6897 , C12Q1/6858
Abstract: Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva.
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