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公开(公告)号：US20200325506A1
公开(公告)日：2020-10-15
申请号：US16673326
申请日：2019-11-04
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US10113152B1
公开(公告)日：2018-10-30
申请号：US14873706
申请日：2015-10-02
Applicant: AbbVie Inc.
Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
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公开(公告)号：US20180194721A1
公开(公告)日：2018-07-12
申请号：US15789133
申请日：2017-10-20
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C12P7/62 , C07C269/06 , C07C67/333 , C07C67/347 , C07C69/74
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US09809534B1
公开(公告)日：2017-11-07
申请号：US14802392
申请日：2015-07-17
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C07C271/24 , C07C269/06 , C07C69/74 , C07C67/333 , C07C67/347 , C12P7/62
CPC classification number: C07C271/24 , C07B2200/07 , C07C67/333 , C07C67/347 , C07C69/65 , C07C69/74 , C07C211/27 , C07C211/35 , C07C269/00 , C07C269/06 , C07C269/08 , C07C2601/02 , C07C2601/14 , C12P7/62
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US10442792B2
公开(公告)日：2019-10-15
申请号：US16132997
申请日：2018-09-17
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07D405/14 , C07D241/44 , C07D405/06 , C07C271/34 , C07C43/196 , C07D487/04 , C07C269/06 , C07C41/26 , C07C67/08 , C07C68/02 , C12P1/00 , C07C211/35 , C12P41/00 , C07C69/74 , C07C269/04
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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Patent Agency Ranking
公开(公告)号：US10421712B2
公开(公告)日：2019-09-24
申请号：US15789133
申请日：2017-10-20
Applicant: AbbVie Inc.
Inventor： Kirill A. Lukin , Jianzhang Mei , David R. Hill , Michael J. Abrahamson
IPC: C12P7/62 , C07C69/65 , C07C69/74 , C07C211/27 , C07C211/35 , C07C269/00 , C07C269/06 , C07C269/08 , C07C271/24 , C07C67/333 , C07C67/347
Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US10316338B1
公开(公告)日：2019-06-11
申请号：US15010557
申请日：2016-01-29
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Angelica B. Kielbus , William T. Riordan , David R. Hill , Sanjay R. Chemburkar , Rajarathnam E. Reddy , Timothy B. Towne , Jianzhang Mei , Gareth J. Brown , Stefan Mix
IPC: C12P7/62
Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
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公开(公告)号：US20190048326A1
公开(公告)日：2019-02-14
申请号：US16172111
申请日：2018-10-26
Applicant: AbbVie Inc.
IPC: C12N9/06
Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
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公开(公告)号：US10059969B1
公开(公告)日：2018-08-28
申请号：US14874001
申请日：2015-10-02
Applicant: AbbVie Inc.
Inventor： Michael J. Abrahamson , Julie J. Pruyne , Angelica B. Kielbus , John E. Lallaman , Rajarathnam E. Reddy , Sanjay R. Chemburkar
IPC: C12P13/04 , C07C51/377 , C07C67/343
CPC classification number: C12P13/04 , C12Y104/01009
Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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公开(公告)号：US20180057482A1
公开(公告)日：2018-03-01
申请号：US15804485
申请日：2017-11-06
Applicant: AbbVie Inc.
Inventor： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC: C07D403/12 , C07C67/08 , C07C41/26 , C07C269/04 , C07C269/06 , C07D487/04 , C07C69/74 , C07C271/34 , C07D405/06 , C07D241/44 , C07D405/14 , C07C43/196
CPC classification number: C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C07C69/96 , C07C69/14
Abstract: The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
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