公开(公告)号：US5710154A

公开(公告)日：1998-01-20

申请号：US459225

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558 ,  C07D413/14 ,  C07F9/6518

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被体内转化成羟基的一个或两个基团（例如，其聚醚酯，氨基酸酯或磷酸酯）或其药学上可接受的盐和药学上可接受的盐取代的直链或支链（C3至C8）烷基 公开了可用于治疗和/或预防真菌感染的组合物。

公开(公告)号：US20050059606A1

公开(公告)日：2005-03-17

申请号：US10934141

申请日：2004-09-03

申请人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Ashok Arasappan ,  Tejal Parekh ,  Patrick Pinto ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Yi-Tsung Liu ,  F. Njoroge ,  Ashit Ganguly ,  Terence Brunck ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby

发明人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Ashok Arasappan ,  Tejal Parekh ,  Patrick Pinto ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Yi-Tsung Liu ,  F. Njoroge ,  Ashit Ganguly ,  Terence Brunck ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby

IPC分类号： C12N9/99 ,  A61K31/7052 ,  A61K38/00 ,  A61K38/21 ,  A61K38/55 ,  A61K45/00 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P35/00 ,  A61P43/00 ,  C07K7/00 ,  C07K7/02 ,  C07K7/06 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/02

摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些肽的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

公开(公告)号：US5714490A

公开(公告)日：1998-02-03

申请号：US458543

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个氨基酸酯基（例如，在体内可转化为羟基的氨基酸酯基）或其药学上可接受的盐取代的直链或支链（C3至C8）烷基和其药物组合物 有用于治疗和/或预防真菌感染。

公开(公告)号：US5703236A

公开(公告)日：1997-12-30

申请号：US458551

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether ester (e.g., a polyetherester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个羟基部分取代的直链或支链（C3至C8）烷基，其醚酯（例如，聚醚酯或磷酸酯）或其药学上可接受的盐和用于治疗和/ 或预防真菌感染。

公开(公告)号：US5703079A

公开(公告)日：1997-12-30

申请号：US460400

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two polyetyher ester groups (e.g., a polyether ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个聚烯酯基团取代的直链或支链（C3至C8）烷基（例如，可在体内转化为羟基的聚醚酯）或其药学上可接受的盐和其用于治疗的药物组合物 和/或预防真菌感染。

公开(公告)号：US5693626A

公开(公告)日：1997-12-02

申请号：US459145

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558 ,  C07D413/14 ,  C07F9/6518

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two phosphate ester groups (e.g., a phosphate ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个磷酸酯基团取代的直链或支链（C3至C8）烷基（例如，可在体内转化为羟基的磷酸酯）或其药学上可接受的盐和用于治疗的药物组合物 和/或预防真菌感染。

公开(公告)号：US5661151A

公开(公告)日：1997-08-26

申请号：US460752

申请日：1995-06-02

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Raymond G. Lovey ,  Russell E. Pike ,  Haiyan Wang ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  Frank Bennett

IPC分类号： C07D405/14 ,  A61K31/41 ,  A61K31/495 ,  A61K31/675 ,  A61P31/00 ,  A61P31/10 ,  C07D521/00 ,  C07F9/6558 ,  C07D413/14 ,  C07F9/6518

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/65586

摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被一个或两个羟基部分取代的直链或支链（C3至C8）烷基，其醚或酯（例如，聚醚酯氨基酸酯或磷酸酯）或其药学上可接受的盐和药物组合物 其用于治疗和/或预防真菌感染。

公开(公告)号：US5403937A

公开(公告)日：1995-04-04

申请号：US55268

申请日：1993-04-30

申请人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Russell E. Pike ,  Haiyan Wang ,  Raymond G. Lovey ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  William B. Morgan ,  Aleksey Zaks

发明人： Anil K. Saksena ,  Viyyoor M. Girijavallabhan ,  Russell E. Pike ,  Haiyan Wang ,  Raymond G. Lovey ,  Yi-Tsung Liu ,  Ashit K. Ganguly ,  William B. Morgan ,  Aleksey Zaks

IPC分类号： C07C69/63 ,  C07C69/65 ,  C07D263/26 ,  C07D307/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D521/00 ,  C12P7/04 ,  C12P7/62 ,  C12P41/00 ,  C07D249/08

CPC分类号： C07D249/08 ,  C07C69/63 ,  C07C69/65 ,  C07D231/12 ,  C07D233/56 ,  C07D263/26 ,  C07D307/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C12P41/004 ,  C12P7/62 ,  Y02P20/55

摘要： Disclosed is a process for preparing chiral compounds of the formula (I) ##STR1## wherein: X.sup.1 and X.sup.2 are independently F or Cl; and E is --SO.sub.2 R.sup.2, wherein R.sup.2 is C.sub.1 -C.sub.6 alkyl, --C.sub.6 H.sub.4 CH.sub.3 or --CF.sub.3 ; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula ##STR2## wherein: X.sup.1 and X.sup.2 are independently F or Cl; B represents --C(O)Q* or --CH.sub.2 OR"; Q* represents a chiral auxiliary group; R" represents a hydroxy protecting group selected from --CH.sub.2 C.sub.6 H.sub.5, or --C(O)R.sup.1, wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.

摘要翻译： 公开了制备式（I）的手性化合物（I）的方法，其中：X 1和X 2独立地是F或Cl; 并且E是-SO 2 R 2，其中R 2是C 1 -C 6烷基，-C 6 H 4 CH 3或-CF 3; 其对映体和外消旋体，可用于四氢呋喃唑类抗真菌剂的合成。 新颖的式（III）化合物或其成分：其中：X 1和X 2独立地为F或Cl; B表示-C（O）Q *或-CH 2 OR“; Q *表示手性辅助基团; R“表示选自-CH 2 C 6 H 5或-C（O）R 1的羟基保护基，其中R 1是C 1 -C 6烷基; A表示Cl，Br，I或三唑基; 也被披露。

公开(公告)号：US10023977B2

公开(公告)日：2018-07-17

申请号：US14428538

申请日：2013-09-17

申请人： Xinghang Zhang ,  Daniel Bufford ,  Haiyan Wang ,  Yue Liu

发明人： Xinghang Zhang ,  Daniel Bufford ,  Haiyan Wang ,  Yue Liu

IPC分类号： C30B29/68 ,  C30B29/02

摘要： Materials, including metals such as bulk metals, specialty alloys, metallic films and coatings, are made up of many tiny single crystals, which may also be referred to as grains. The boundaries between crystals are called grain boundaries and govern properties such as mechanical strength, deformation, and electrical resistivity. These properties are affected by not only the number of grain boundaries formed, but also the density and orientation of those grain boundaries. Twin boundaries are a special type of grain boundary which have symmetrical “mirror image” structures and preserve favorable qualities of grain boundaries while suppressing unfavorable properties such as the initiation of cracks, inclusions, and other unwanted flaws. Some metals and alloys form twins more easily than others during processing. Metals with low stacking fault energy (SFE) such as austenitic stainless steel, copper (Cu), and silver (Ag) form twin boundaries more easily than metals with high SFE such as Magnesium (Mg) and Aluminum (Al).

公开(公告)号：US08912221B2

公开(公告)日：2014-12-16

申请号：US13329349

申请日：2011-12-19

申请人： Johannes Aebi ,  Alfred Binggeli ,  Cornelia Hertel ,  Anish Ashok Konkar ,  Holger Kuehne ,  Bernd Kuhn ,  Hans P. Maerki ,  Haiyan Wang

发明人： Johannes Aebi ,  Alfred Binggeli ,  Cornelia Hertel ,  Anish Ashok Konkar ,  Holger Kuehne ,  Bernd Kuhn ,  Hans P. Maerki ,  Haiyan Wang

IPC分类号： A61K31/443 ,  C07D413/14 ,  C07D405/14 ,  C07D413/12 ,  C07D405/12 ,  C07D305/08 ,  C07D417/14

CPC分类号： C07D305/08 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12和A如本文所述，包括该化合物和 使用化合物。