公开(公告)号：US10208323B2

公开(公告)日：2019-02-19

申请号：US14731037

申请日：2015-06-04

Applicant: BASF SE

Inventor： Hartwig Schroeder ,  Holger Hartmann ,  Qingzhao Wang ,  Shakir Siraj Ratani ,  Zheyuan Guo ,  Markus Pompejus

IPC: C12N15/00 ,  C12N1/20 ,  C12P13/06 ,  C07K14/245 ,  C12N9/06 ,  C12P7/04 ,  C12P7/46 ,  C12P7/56 ,  C12P13/08 ,  C12P13/20 ,  A61K38/00

Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：US20150376663A1

公开(公告)日：2015-12-31

申请号：US14731037

申请日：2015-06-04

Applicant: BASF SE

Inventor： Hartwig Schroeder ,  Holger Hartmann ,  Qingzhao Wang ,  Shakir Ratani ,  Zheyuan Guo ,  Markus Pompejus

IPC: C12P13/06 ,  C07K14/245 ,  C12N9/06

CPC classification number: C12P13/06 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0016 ,  C12P7/04 ,  C12P7/46 ,  C12P7/56 ,  C12P13/08 ,  C12P13/20 ,  C12Y104/01001

Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

Abstract translation: 本发明涉及重组微生物，其用于制备丙氨酸的方法，以及重组核酸分子或重组微生物用于发酵生产丙氨酸的用途。

公开(公告)号：US20150275248A1

公开(公告)日：2015-10-01

申请号：US14441215

申请日：2013-11-13

Applicant: BASF SE

Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

IPC: C12P17/04 ,  C12N15/80

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

公开(公告)号：US20150211036A1

公开(公告)日：2015-07-30

申请号：US14421872

申请日：2013-08-13

Applicant: BASF SE ,  Evolva SA

Inventor： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC: C12P17/12 ,  C12N9/02 ,  C07D209/90 ,  C12P17/10 ,  C07K16/40 ,  C07D487/06 ,  C12N9/10 ,  C12N9/90

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。