公开(公告)号：US10315975B2

公开(公告)日：2019-06-11

申请号：US15743153

申请日：2016-07-08

Applicant: BASF SE ,  Ruprecht-Karls-Universität Heidelberg ,  Christa Johanna Hofmann ,  Stefanie Hoffman

Inventor： Julia Strautmann ,  Stefan Rüdenauer ,  Christian Rein ,  Melanie Weingarten ,  Rocco Paciello ,  Wolfgang Siegel ,  Michael Breuer ,  Peter Hofmann ,  Sebastian Schmidt

IPC: C07C45/50 ,  B01J31/00 ,  C07C47/21 ,  C07D307/92 ,  C07C29/141 ,  C07C29/56 ,  B01J31/18 ,  C07C33/025

Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

公开(公告)号：US20160201093A1

公开(公告)日：2016-07-14

申请号：US14908293

申请日：2014-07-21

Applicant: BASF SE

Inventor： Michael Breuer ,  Boris Breitscheidel ,  Hans-Günter Wagner ,  Detlef Kratz ,  Bernhard Hauer ,  Daniel Scheps ,  Bernd Nebel

IPC: C12P7/16 ,  C12P7/04

CPC classification number: C12P7/16 ,  C12P7/04 ,  C12Y114/15003 ,  C12Y118/01001 ,  Y02E50/10

Abstract: A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen.

Abstract translation: 通过在氧气存在下在升高的压力下孵育具有功能性P153酶的宿主生物体，从具有3至13个碳原子的直链或支链烷烃制备具有3至13个碳原子的直链或支链伯醇的方法。

公开(公告)号：US20150104851A1

公开(公告)日：2015-04-16

申请号：US14560263

申请日：2014-12-04

Applicant: BASF SE

Inventor： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabrielle Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Racolta

IPC: C12N9/90

CPC classification number: C12N9/88 ,  C12N9/90 ,  C12P5/007 ,  C12P7/02 ,  C12P7/22 ,  C12Y406/01 ,  C12Y504/99017 ,  Y02P20/52

Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

Abstract translation: 本发明涉及具有环化酶活性的新颖突变体及其在萜烯生物催化环化方法中的应用，特别是通过香茅醛环化生产异胡胆糖; 用于制备薄荷醇的方法和用于生物催化转化具有类似于萜烯的结构基序的其它化合物的方法。

公开(公告)号：US20140141440A1

公开(公告)日：2014-05-22

申请号：US14084030

申请日：2013-11-19

Applicant: BASF SE

Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

IPC: C12P17/04

CPC classification number: C12P17/04 ,  C12N15/52 ,  C12P7/50

Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

公开(公告)号：US20250034605A1

公开(公告)日：2025-01-30

申请号：US18717729

申请日：2022-12-12

Applicant: BASF SE

Inventor： Gunther Zimmermann ,  Moritz Stefan Pott ,  Michael Breuer ,  Klaus Ditrich ,  Stefan Seemayer

IPC: C12P9/00 ,  A01N57/20 ,  C12N9/80 ,  C12N9/86 ,  C12N9/90 ,  C12P41/00

Abstract: The present invention relates to a method of manufacturing glufosinate, comprising the step of enzymatically cleaving off a carbamoyl moiety of a carbamoyl amino acid compound.

公开(公告)号：US20220259580A1

公开(公告)日：2022-08-18

申请号：US17416480

申请日：2019-12-09

Applicant: BASF SE

Inventor： Kai-Uwe Baldenius ,  Michael Breuer ,  Corinna Ruffer ,  Melanie Weingarten ,  Reinhard Zschoche ,  Stefan Seemayer ,  Bernd Nidetzky ,  Katharina Schmoelzer ,  Michael Puhl

IPC: C12N9/24 ,  C12P19/14 ,  C12P19/18 ,  C12N1/20

Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.

公开(公告)号：US09631212B2

公开(公告)日：2017-04-25

申请号：US14441215

申请日：2013-11-13

Applicant: BASF SE

Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

IPC: C12N15/80 ,  C12P17/04 ,  C12N15/67 ,  C07D307/93 ,  C12N15/52 ,  C07K14/37 ,  A01N37/46 ,  A01N63/04 ,  A01N37/42

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：US12203114B2

公开(公告)日：2025-01-21

申请号：US17286328

申请日：2019-10-09

Applicant: BASF SE

Inventor： Diego Ghislieri ,  Tobias Joachim Zimmermann ,  Stefan Seemayer ,  Michael Breuer ,  Doreen Schachtschabel

IPC: C12N9/78 ,  C12P7/40 ,  C12P7/60

Abstract: Described herein are methods for the production of ammonium acrylate or salts thereof from acrylonitrile using nitrilase as a catalyst.

公开(公告)号：US10954538B2

公开(公告)日：2021-03-23

申请号：US15999299

申请日：2017-02-20

Applicant: BASF SE

Inventor： Michael Breuer ,  Wolfgang Siegel ,  Stefan Ruedenauer ,  Ralf Pelzer

IPC: C12P17/04

Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.

公开(公告)号：US10717973B2

公开(公告)日：2020-07-21

申请号：US16212287

申请日：2018-12-06

Applicant: BASF SE

Inventor： Michael Breuer ,  Bernhard Hauer ,  Dieter Jendrossek ,  Gabriele Siedenburg ,  Juergen Pleiss ,  Demet Sirim ,  Silvia Fadenrecht

IPC: C12P7/22 ,  C12P7/02 ,  C12N9/88 ,  C12N9/90 ,  C12P5/00

Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.