公开(公告)号：US10669508B2

公开(公告)日：2020-06-02

申请号：US16344646

申请日：2017-10-25

Applicant: BASF SE

Inventor： Ralf Pelzer

IPC: A61Q13/00 ,  A61K8/18 ,  A61K8/00 ,  C11B9/00 ,  C07C49/337 ,  C07C49/543 ,  A61K8/35

Abstract: Use of 1-[(4R)-4-methylcyclohexen-1-yl]ethanone to impart a ylang-ylang note to a composition.

公开(公告)号：US10106517B2

公开(公告)日：2018-10-23

申请号：US15555723

申请日：2016-03-04

Applicant: BASF SE)

Inventor： Stefan Rüdenauer ,  Timon Stork ,  Ralf Pelzer ,  Volker Hickmann ,  Margarethe Klos

IPC: C07D309/12

Abstract: The present invention relates to a method for preparing tetrahydropyranyl esters from the corresponding 4-hydroxytetrahydropyran compounds by reaction with a ketene compound.

公开(公告)号：US09920007B2

公开(公告)日：2018-03-20

申请号：US15526962

申请日：2015-11-17

Applicant: BASF SE

Inventor： Stefan Rüdenauer ,  Ralf Pelzer ,  Miriam Bru Roig ,  Vijay Narayanan Swaminathan ,  Shrirang Hindalekar ,  Nitin Gupte ,  Prachin Kolambkar

IPC: C07C403/16 ,  C07C29/00 ,  C11B9/00 ,  C07C29/17 ,  A23L27/20

CPC classification number: C07C403/16 ,  A23L27/203 ,  C07C29/175 ,  C07C2601/14 ,  C07C2601/16 ,  C11B9/0034 ,  C07C31/1355

Abstract: The present invention relates to a process for the preparation of 1-(2,6,6-trimethylcyclohexylyalkan-3-ols, in particular 1-(2,6,6-trimethylcyclohexyl)-hexan-3-ol. The invention further relates to 5-alkoxy-1-(2,6,6-trimethylcyclohexenyl)-1-alken-3-ones and the use of these as a fragrance or as flavor, to a fragrance containing composition and/or a fragranced product containing 5-alkoxy-1-(2,6,6-trimethylcyclohexenyl)-1-alken-3-ones and to a method for imparting or modifying a scent or a flavor to a composition by including said alkoxyalkenones into such composition.

公开(公告)号：US20160213582A1

公开(公告)日：2016-07-28

申请号：US15092289

申请日：2016-04-06

Applicant: BASF SE

Inventor： Stefan Rüdenauer ,  Ralf Pelzer ,  Klaus Ebel ,  Martin Bock

IPC: A61K8/34 ,  A61Q13/00 ,  C11D3/50 ,  A61Q19/00

CPC classification number: A61K8/34 ,  A61K2800/10 ,  A61Q13/00 ,  A61Q19/00 ,  C07C29/19 ,  C07C29/44 ,  C07C2601/14 ,  C11D3/2024 ,  C11D3/2065 ,  C11D3/50 ,  C07C33/20 ,  C07C31/1355

Abstract: The present invention relates to processes for the preparation of compounds of the formula (Ia) by reacting styrene with a secondary alkanol and the hydrogenation of the resulting phenyl-substituted tertiary alkanol. In addition, the invention relates to compounds of the formula (Ia) and to the use of such compounds as fragrances, and also to compositions which comprise compounds of the formulae (Ia) and (Ib).

Abstract translation: 本发明涉及通过苯乙烯与仲链烷醇的反应和所得苯基取代的叔链烷醇的氢化制备式（Ia）化合物的方法。 此外，本发明涉及式（Ia）化合物和这些化合物作为香料的用途，还涉及包含式（Ia）和（Ib）的化合物的组合物。

公开(公告)号：US20150246864A1

公开(公告)日：2015-09-03

申请号：US14709948

申请日：2015-05-12

Applicant: BASF SE

Inventor： Rudolf Schuch ,  Stefan Rüdenauer ,  Klaus Ebel ,  Ralf Pelzer ,  Andreas Keller

IPC: C07C29/44 ,  C07C29/80 ,  C07C29/19

CPC classification number: C07C29/44 ,  B01J21/08 ,  B01J23/462 ,  B01J23/56 ,  B01J33/00 ,  B01J35/0026 ,  B01J35/008 ,  B01J35/023 ,  B01J35/08 ,  B01J35/1019 ,  B01J35/1042 ,  B01J35/1061 ,  B01J35/108 ,  B01J37/0203 ,  B01J37/18 ,  C07C29/19 ,  C07C29/80 ,  C07C2601/14 ,  C11B9/0061 ,  C07C33/20 ,  C07C31/1355

Abstract: A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

Abstract translation: 一种制备4-环己基-2-甲基-2-丁醇的方法，包括：a）在升高的温度下使苯乙烯与异丙醇反应得到2-甲基-4-苯基-2-丁醇，和b）异构催化氢化2 - 甲基-4-苯基-2-丁醇，其适用于芳族化合物的环加氢，其中步骤a）中使用的苯乙烯的摩尔比与步骤a）中使用的异丙醇的摩尔比在1：低于5至 1：0.5。

公开(公告)号：US20150225325A1

公开(公告)日：2015-08-13

申请号：US14693943

申请日：2015-04-23

Applicant: BASF SE

Inventor： Klaus EBEL ,  Stefan Rüdenauer ,  Ralf Pelzer ,  Martin Bock

IPC: C07C31/135 ,  A61Q19/00 ,  C11D3/50 ,  C07C29/44 ,  C11B9/00 ,  A61K8/34 ,  C07C29/19

CPC classification number: C07C31/1355 ,  A61K8/34 ,  A61K2800/10 ,  A61Q13/00 ,  A61Q19/00 ,  C07C29/19 ,  C07C29/20 ,  C07C29/44 ,  C07C29/80 ,  C07C33/20 ,  C07C2601/14 ,  C11B9/0034 ,  C11B9/0061 ,  C11D3/2017 ,  C11D3/50

Abstract: The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.

Abstract translation: 本发明涉及一种制备4-环己基-2-甲基-2-丁醇的方法。 该方法包括以下步骤：a）在高温下使苯乙烯与异丙醇反应，得到4-苯基-2-甲基-2-丁醇，b）4-苯基-2-甲基-2-丁醇的非均相催化氢化 适用于芳族化合物环加氢的催化剂。

公开(公告)号：US20140163117A1

公开(公告)日：2014-06-12

申请号：US14090626

申请日：2013-11-26

Applicant: BASF SE

Inventor： Stefan Rüdenauer ,  Ralf Pelzer ,  Klaus Ebel ,  Martin Bock

IPC: C07C29/36 ,  C07C31/135 ,  C11D3/20 ,  A61K8/34

CPC classification number: A61K8/34 ,  A61K2800/10 ,  A61Q13/00 ,  A61Q19/00 ,  C07C29/19 ,  C07C29/44 ,  C07C2601/14 ,  C11D3/2024 ,  C11D3/2065 ,  C11D3/50 ,  C07C33/20 ,  C07C31/1355

Abstract: The present invention relates to processes for the preparation of compounds of the formula (Ia) by reacting styrene with a secondary alkanol and the hydrogenation of the resulting phenyl-substituted tertiary alkanol. In addition, the invention relates to compounds of the formula (Ia) and to the use of such compounds as fragrances, and also to compositions which comprise compounds of the formulae (Ia) and (Ib).

Abstract translation: 本发明涉及通过苯乙烯与仲链烷醇的反应和所得苯基取代的叔链烷醇的氢化制备式（Ia）化合物的方法。 此外，本发明涉及式（Ia）化合物和这些化合物作为香料的用途，还涉及包含式（Ia）和（Ib）的化合物的组合物。

公开(公告)号：US20140100376A1

公开(公告)日：2014-04-10

申请号：US14063022

申请日：2013-10-25

Applicant: BASF SE

Inventor： Itamar Michael Malkowsky ,  Florian Stecker ,  Simone Lutter ,  Olivier Abillard ,  Ralf Pelzer

IPC: C07D307/33 ,  C07C67/31 ,  C07C51/367

CPC classification number: C07D307/33 ,  A23L27/2052 ,  C07C51/367 ,  C07C67/31 ,  C11B9/0076 ,  C25B3/04

Abstract: γ-Hydroxycarboxylic esters and γ-lactones which are suitable as flavors can be prepared by electrochemical reductive cross-coupling of α,β-unsaturated esters with carbonyl compounds in an undivided electrolysis cell having a cathode composed of lead, lead alloys, cadmium, cadmium alloys, mercury, steel, glassy carbon or boron-doped diamonds and a basic aqueous electrolyte comprising an electrolyte salt which suppresses the cathodic formation of hydrogen.

Abstract translation: 适合作为香料的γ-羟基羧酸酯和γ-内酯可以通过在具有由铅，铅合金，镉，镉等的阴极组成的不分开的电解槽中的α，bgr-不饱和酯与羰基化合物的电化学还原交叉偶联来制备， 镉合金，汞，钢，玻璃碳或硼掺杂的金刚石和碱性含水电解质，其包含抑制氢的阴极形成的电解质盐。

公开(公告)号：US20130338402A1

公开(公告)日：2013-12-19

申请号：US13916082

申请日：2013-06-12

Applicant: BASF SE

Inventor： Richard Dehn ,  Joaquim Henrique Teles ,  Michael Limbach ,  Stephan Deuerlein ,  Manuel Danz ,  Ralf Pelzer ,  Daniel Schneider

IPC: C07C45/68 ,  C07C49/547 ,  C07C49/527 ,  C07C45/67

CPC classification number: C07C45/68 ,  C07C45/673 ,  C07C49/527 ,  C07C49/547 ,  C07C2601/18 ,  C07C49/607 ,  C07C49/587

Abstract: The present invention relates to a process for preparing cyclic compounds having at least eight carbon atoms and at least one keto group, to the cyclic compounds obtained by this process and to the use thereof, in particular as fragrance or for providing a fragrance.

Abstract translation: 本发明涉及一种制备具有至少8个碳原子和至少一个酮基的环状化合物与通过该方法获得的环状化合物及其用途，特别是作为香料或提供香料的方法。

公开(公告)号：US11434220B2

公开(公告)日：2022-09-06

申请号：US16642954

申请日：2018-08-31

Applicant: BASF SE ,  SYMRISE AG

Inventor： Benoît Join ,  Jekaterina Ongouta ,  Michael Backes ,  Rahim Brodhage ,  Arnold Machinek ,  Hubert Loges ,  Susanne Mundt ,  Tom Somers ,  Thomas Subkowski ,  Jens Wittenberg ,  Martin Weisel ,  Wolfgang Siegel ,  Claus Bollschweiler ,  Ralf Pelzer

IPC: C07D317/46 ,  C07C323/41 ,  C07D405/12 ,  C07D213/75 ,  C07D231/40 ,  C07D407/12 ,  C07D307/14 ,  C07D409/12 ,  C07D409/14 ,  C07D405/14 ,  A61K8/49 ,  A61K8/46 ,  A61Q11/00 ,  A23L29/00 ,  A23L27/00 ,  A23G3/36

Abstract: The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.