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11.发明授权Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8 有权检测和使用低分子量的冷 - 薄荷醇受体TRPM8的调节剂公开(公告)号：US09346823B2
公开(公告)日：2016-05-24
申请号：US14206182
申请日：2014-03-12
Applicant: BASF SE
Inventor： Thomas Subkowski , Claus Bollschweiler , Jens Wittenberg , Michael Krohn , Holger Zinke
IPC: A61Q17/02 , A61K8/42 , A23L1/22 , C07D495/22 , A61K8/49 , A61K8/69 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61K31/00 , C07C275/28 , C07D211/14 , C07D233/84 , C07D241/44 , C07D317/64 , C07D401/04 , C07D401/12 , C07D409/12 , C07D495/20
CPC classification number: C07D495/22 , A23L27/88 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/69 , A61K31/00 , A61K2800/244 , A61K2800/78 , A61Q5/02 , A61Q11/00 , A61Q17/02 , A61Q17/04 , A61Q19/004 , C07C275/28 , C07D211/14 , C07D233/84 , C07D241/44 , C07D317/64 , C07D401/04 , C07D401/12 , C07D409/12 , C07D495/20
Abstract: The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.
Abstract translation: 本发明涉及冷薄荷醇受体TRPM8的新型调节剂，涉及使用所述调节剂调节TRPM8受体的方法; 使用调制器诱导感冒; 以及使用所述调制器产生的物体和装置。
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Patent Agency Ranking
12.发明申请USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 审中-公开使用生理冷却活性成分，以及含有此类活性成分的试剂公开(公告)号：US20150086491A1
公开(公告)日：2015-03-26
申请号：US14533345
申请日：2014-11-05
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A61K31/4375 , C07D491/147 , A61K31/506 , A23L1/30 , A61K31/5377 , A61K8/49 , A61Q11/00 , A24B13/00 , A24D1/00 , A61K31/438 , C07D401/04
CPC classification number: C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
Abstract translation: 本发明涉及一种用于实现对皮肤或粘膜的冷却作用的TRPM8调节剂。
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公开(公告)号：US10898739B2
公开(公告)日：2021-01-26
申请号：US16715273
申请日：2019-12-16
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-liverman , Lynette Zaidel
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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14.发明授权公开(公告)号：US10584134B2
公开(公告)日：2020-03-10
申请号：US15629015
申请日：2017-06-21
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A23L27/20 , A23L33/10 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23G3/36 , A23G4/06 , A23L2/52 , A61K8/49 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61Q19/00 , A61Q17/04
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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公开(公告)号：US20190201721A1
公开(公告)日：2019-07-04
申请号：US15771236
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Thorsten Henkes , Sandra Facey , Bernhard Hauer
Abstract: Provided herein are oral care compositions comprising HABP, which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US20190022429A1
公开(公告)日：2019-01-24
申请号：US15770978
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel
CPC classification number: A61Q11/00 , A61K8/21 , A61K8/64 , A61K9/0058
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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