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公开(公告)号：US09758492B2
公开(公告)日：2017-09-12
申请号：US14914184
申请日：2014-08-26
Applicant: Bristol-Myers Squibb Company
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , Shefali Srivastava , David K. Williams , Libing Chen
IPC: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07D211/14 , C07D237/20 , C07D333/38 , C07D401/10 , C07D407/12 , C07D417/12 , C07D403/12 , C07D309/14 , C07D215/06 , C07D231/12 , C07D333/10 , C07D401/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D277/22 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07B59/00
CPC classification number: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
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公开(公告)号：US20160200674A1
公开(公告)日：2016-07-14
申请号：US14914184
申请日：2014-08-26
Applicant: Bristol-Myers Squibb Company
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , Shefali Srivastava , David K. Williams , Libing Chen
IPC: C07C275/42 , A61K31/41 , A61K45/06 , C07C311/09 , A61K31/18 , A61K31/17 , C07D417/12 , A61K31/427 , C07D333/38 , A61K31/381 , C07D401/10 , A61K31/4439 , C07D407/12 , C07D211/14 , A61K31/451 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/422 , A61K31/497 , A61K31/4709 , C07D237/20 , A61K31/50 , A61K31/5375 , C07D257/04
CPC classification number: C07D257/04 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/451 , A61K31/4709 , A61K31/497 , A61K31/50 , A61K31/506 , A61K31/5375 , A61K45/06 , C07B59/002 , C07C275/42 , C07C311/05 , C07C311/09 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D211/14 , C07D215/06 , C07D231/12 , C07D237/20 , C07D277/22 , C07D309/14 , C07D333/10 , C07D333/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法，例如癌症，病毒感染和/或自身免疫疾病，其利用 发明。
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公开(公告)号：US09371328B2
公开(公告)日：2016-06-21
申请号：US14191861
申请日：2014-02-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC: C07D487/04 , C07D498/04
CPC classification number: C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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公开(公告)号：US20160060237A1
公开(公告)日：2016-03-03
申请号：US14775976
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Weifang Shan
IPC: C07D305/06 , A61K31/196 , A61K31/337 , C07D261/14 , A61K31/42 , A61K45/06 , A61K31/41 , C07D241/42 , A61K31/498 , C07D239/42 , A61K31/505 , C07C275/42 , C07D255/02
CPC classification number: C07D305/06 , A61K31/196 , A61K31/337 , A61K31/41 , A61K31/42 , A61K31/498 , A61K31/505 , A61K45/06 , C07C275/42 , C07C2101/14 , C07C2601/14 , C07D239/42 , C07D241/42 , C07D255/02 , C07D261/14
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法，例如癌症，病毒感染和/或自身免疫疾病，其利用 发明。 式（I）。
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公开(公告)号：US20150210697A1
公开(公告)日：2015-07-30
申请号：US14414152
申请日：2013-07-12
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07F7/18 , C07D487/10 , C07D487/08 , C07D471/10
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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Patent Agency Ranking
公开(公告)号：US11339185B2
公开(公告)日：2022-05-24
申请号：US16683667
申请日：2019-11-14
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07H21/02 , C07H21/00 , C07K16/28
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20210253624A1
公开(公告)日：2021-08-19
申请号：US16849091
申请日：2018-10-16
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. FINK , Yufen Zhao , Libing Chen , Audris Huang
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09624188B2
公开(公告)日：2017-04-18
申请号：US14775976
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Weifang Shan
IPC: C07D305/06 , A61K31/196 , C07C275/42 , C07D239/42 , C07D241/42 , C07D255/02 , A61K31/337 , A61K31/41 , A61K31/42 , A61K31/498 , A61K31/505 , A61K45/06 , C07D261/14
CPC classification number: C07D305/06 , A61K31/196 , A61K31/337 , A61K31/41 , A61K31/42 , A61K31/498 , A61K31/505 , A61K45/06 , C07C275/42 , C07C2101/14 , C07C2601/14 , C07D239/42 , C07D241/42 , C07D255/02 , C07D261/14
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).
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公开(公告)号：US09427442B2
公开(公告)日：2016-08-30
申请号：US14429958
申请日：2013-09-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yufen Zhao , Ashvinikumar V. Gavai , Patrice Gill , Soong-Hoon Kim , Brian E. Fink , Libing Chen , Mark G. Saulnier , Wen-Ching Han
IPC: C07D243/24 , A61K31/5513 , A61K45/06
CPC classification number: A61K31/5513 , A61K31/138 , A61K31/337 , A61K31/506 , A61K31/555 , A61K45/06 , C07D243/18 , C07D243/24 , C07D243/26 , A61K2300/00
Abstract: Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Abstract translation: 公开了式（I）的化合物：（式（I））其中：R 1是-CH 2 CH 2 CF 3; R2是-CH2CH2CH2F，-CH2CF2CH3，-CH2CH2CF3，-CH2CH（CH3）CF3，-CH2CH2CF2CH3，（式（Ⅱ），（Ⅲ），（Ⅳ），（Ⅴ）或（Ⅵ）：R3是H或-CH3; 环A是苯基或吡啶基; Rx，Ry，Ra，Rb，y和z在本文中定义。还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物，这些化合物可用于 治疗，预防或减缓各种治疗领域（例如癌症）中的疾病或病症的发展。
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公开(公告)号：US20150231152A1
公开(公告)日：2015-08-20
申请号：US14429958
申请日：2013-09-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yufen Zhao , Ashvinikumar V. Gavai , Patrice Gill , Soong-Hoon Kim , Brian E. Fink , Libing Chen , Mark G. Saulnier , Wen-Ching Han
IPC: A61K31/5513 , A61K45/06 , C07D243/24
CPC classification number: A61K31/5513 , A61K31/138 , A61K31/337 , A61K31/506 , A61K31/555 , A61K45/06 , C07D243/18 , C07D243/24 , C07D243/26 , A61K2300/00
Abstract: Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Abstract translation: 公开了式（I）的化合物：（式（I））其中：R 1是-CH 2 CH 2 CF 3; R2是-CH2CH2CH2F，-CH2CF2CH3，-CH2CH2CF3，-CH2CH（CH3）CF3，-CH2CH2CF2CH3，（式（Ⅱ），（Ⅲ），（Ⅳ），（Ⅴ）或（Ⅵ）：R3是H或-CH3; 环A是苯基或吡啶基; Rx，Ry，Ra，Rb，y和z在本文中定义。还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物，这些化合物可用于 治疗，预防或减缓各种治疗领域（例如癌症）中的疾病或病症的发展。
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