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公开(公告)号：US09278962B2
公开(公告)日：2016-03-08
申请号：US14270566
申请日：2014-05-06
申请人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D417/12 , C07D417/06 , C07D417/04 , C07D285/08 , C07D401/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/14 , C07D249/14 , C07D271/07 , C07D277/42 , C07D285/135 , A61K31/428 , A61K31/4439 , C07D277/82
CPC分类号： C07D401/12 , A61K31/428 , A61K31/4439 , C07D249/14 , C07D271/07 , C07D271/113 , C07D277/42 , C07D277/82 , C07D285/08 , C07D285/135 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US08686007B2
公开(公告)日：2014-04-01
申请号：US13612715
申请日：2012-09-12
申请人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/433 , C07D417/04 , C07D417/12 , C07D417/14 , C07D285/135
CPC分类号： C07D401/12 , A61K31/428 , A61K31/4439 , C07D249/14 , C07D271/07 , C07D271/113 , C07D277/42 , C07D277/82 , C07D285/08 , C07D285/135 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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13.发明申请公开(公告)号：US20120289698A1
公开(公告)日：2012-11-15
申请号：US13446432
申请日：2012-04-13
申请人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D417/12 , C07D417/04 , C07D417/06 , C07D417/10 , C07D233/88 , C07D413/04 , C07D401/12 , C07D271/113 , C07D249/14 , C07D285/08 , C07D417/14
CPC分类号： C07D401/12 , A61K31/428 , A61K31/4439 , C07D249/14 , C07D271/07 , C07D271/113 , C07D277/42 , C07D277/82 , C07D285/08 , C07D285/135 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US07605164B2
公开(公告)日：2009-10-20
申请号：US11353252
申请日：2006-02-14
申请人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： A61K31/497 , A61K31/381 , A61K31/4409 , A61K31/4406 , A61K31/4402 , A61K31/42 , A61P9/04 , C07D401/10 , C07D403/10 , C07D213/643 , C07D213/65 , C07D213/68 , C07D261/18 , C07D333/22
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要： Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的苯甲酰胺衍生物选择性地调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US07053094B2
公开(公告)日：2006-05-30
申请号：US11040478
申请日：2005-01-20
申请人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/42 , A01N43/40 , A01N43/80
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要： Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US06908923B2
公开(公告)日：2005-06-21
申请号：US10327219
申请日：2002-12-20
申请人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： C07D333/40 , A61K31/381 , A61K31/42 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/497 , A61P9/00 , A61P9/04 , C07D213/64 , C07D213/65 , C07D213/75 , C07D213/78 , C07D213/81 , C07D261/18 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , A61K31/4965 , A01N43/40 , A01N43/80 , A61K31/44
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要： Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的式I的苯甲酰胺衍生物：选择性调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20070149516A1
公开(公告)日：2007-06-28
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/5383 , A61K31/4745 , A61K31/424 , A61K31/4196 , A61K31/4172
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US20060094708A1
公开(公告)日：2006-05-04
申请号：US11121709
申请日：2005-05-03
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
IPC分类号： A61K31/55 , A61K31/4745 , A61K31/424 , A61K31/421 , A61K31/4196 , A61K31/4184 , C07D491/02 , C07D487/02
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20060247289A1
公开(公告)日：2006-11-02
申请号：US11271147
申请日：2005-11-09
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/4184 , A61K31/4172 , C07D233/61
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US20070197481A1
公开(公告)日：2007-08-23
申请号：US11124608
申请日：2005-05-06
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/66 , A61K31/538 , A61K31/4172 , A61K31/4745 , A61K31/426 , A61K31/421
CPC分类号： C07D403/12 , A61K31/4172 , A61K31/421 , A61K31/426 , A61K31/4745 , A61K31/538 , A61K31/66 , A61K45/06 , C07C235/48 , C07C235/50 , C07C237/22 , C07C255/44 , C07C255/57 , C07C255/60 , C07C271/28 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D231/12 , C07D235/18 , C07D239/22 , C07D261/08 , C07D271/06 , C07D277/42 , C07D285/12 , C07D295/15 , C07D333/38 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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