公开(公告)号：US09326756B2

公开(公告)日：2016-05-03

申请号：US11646525

申请日：2006-12-28

Applicant: Todd Stangenes ,  Brian Schmidt ,  Xuan Khieu

Inventor： Todd Stangenes ,  Brian Schmidt ,  Xuan Khieu

IPC: A61M5/178 ,  A61B17/00 ,  A61B17/34 ,  A61B18/00 ,  A61B19/00 ,  A61M25/00 ,  A61M25/06

CPC classification number: A61B17/00234 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/0046 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M25/0084 ,  A61M2025/0681

Abstract: Improved hand assemblies and methods combining a number of the separate known devices used in transseptal catheterization procedures, including sheaths, dilators, and needle assemblies (including a puncture device and a stylet, for example). The hand assemblies provide cooperating members that reduce the overall complexity and increase safety of transseptal catheterization procedures.

Abstract translation: 改进的手组件和方法组合了用于经导管插入术过程中的多个单独的已知装置，包括护套，扩张器和针组件（例如包括穿刺装置和探针）。 手组件提供协作的构件，其减少整体复杂性并增加经导管插入术的安全性。

公开(公告)号：US08741609B2

公开(公告)日：2014-06-03

申请号：US13518354

申请日：2010-12-14

Applicant: Christian Adams ,  Brian Schmidt

Inventor： Christian Adams ,  Brian Schmidt

IPC: C12P21/06

CPC classification number: C11D3/38627 ,  C12N9/20

Abstract: The present compositions and methods relate to a lipase cloned from Geobacillus stearothermophilus, polynucleotides encoding the lipase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and methods.

Abstract translation: 本发明的组合物和方法涉及从嗜热脂肪芽孢杆菌克隆的脂肪酶，编码脂肪酶的多核苷酸及其使用方法。 组合物和方法在洗涤剂清洁组合物和方法中具有特别的应用。

公开(公告)号：US20120315689A1

公开(公告)日：2012-12-13

申请号：US13518346

申请日：2010-12-02

Applicant: Christian Adams ,  Katherine D. Collier ,  Michael Jay Pepsin ,  Brian Schmidt

Inventor： Christian Adams ,  Katherine D. Collier ,  Michael Jay Pepsin ,  Brian Schmidt

IPC: C11D3/386

CPC classification number: C11D3/38627 ,  C11D1/62 ,  C11D1/662 ,  C11D1/72 ,  C11D1/75 ,  C11D1/886 ,  C11D1/92 ,  C11D3/221 ,  C12N9/20 ,  C12Y301/01003

Abstract: Described are compositions and methods relating to the removal of oily stains from fabrics and other surfaces using a lipase in combination with a selected surfactant to mediate the release of fatty acids generated by the lipase. The compositions and methods have application in, e.g., laundry cleaning and dishwashing.

Abstract translation: 描述了与使用脂肪酶与所选择的表面活性剂组合以介导由脂肪酶产生的脂肪酸的释放从织物和其它表面除去油性污渍有关的组合物和方法。 组合物和方法可用于例如洗衣清洁和洗碗。

公开(公告)号：US20120014885A1

公开(公告)日：2012-01-19

申请号：US11919717

申请日：2006-04-25

Applicant: Katherine D. Collier ,  Anthony Day ,  Hans de Nobel ,  David A. Estell ,  Grant C. Ganshaw ,  Marc Kolkman ,  Raj Lad ,  Jeffrey V. Miller ,  Christopher J. Murray ,  Scott D. Power ,  Brian Schmidt ,  Anita Van Kimmenade ,  Gudrun Vogtentanz

Inventor： Katherine D. Collier ,  Anthony Day ,  Hans de Nobel ,  David A. Estell ,  Grant C. Ganshaw ,  Marc Kolkman ,  Raj Lad ,  Jeffrey V. Miller ,  Christopher J. Murray ,  Scott D. Power ,  Brian Schmidt ,  Anita Van Kimmenade ,  Gudrun Vogtentanz

IPC: A61K8/64 ,  A61Q17/04 ,  A61Q5/00 ,  A61Q1/02 ,  A61Q19/10 ,  A61Q1/10 ,  A61K38/08 ,  A61K38/16 ,  A61Q7/02 ,  C07K19/00 ,  A61Q15/00 ,  A61Q1/06

CPC classification number: A61K8/64 ,  A61K8/66 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q7/02 ,  A61Q9/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/10 ,  C07K7/06

Abstract: The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.

Abstract translation: 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。

公开(公告)号：US20100249809A1

公开(公告)日：2010-09-30

申请号：US12722134

申请日：2010-03-11

Applicant: Wamis Singhatat ,  Jamie Manos ,  Brian Rick Delamarter ,  Dominique Messerli ,  Brian Schmidt ,  William Miller ,  James Talbot ,  Garland Fussell ,  Nigel G. Smith

Inventor： Wamis Singhatat ,  Jamie Manos ,  Brian Rick Delamarter ,  Dominique Messerli ,  Brian Schmidt ,  William Miller ,  James Talbot ,  Garland Fussell ,  Nigel G. Smith

IPC: A61B17/04

CPC classification number: A61B17/0485 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0469 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/06052

Abstract: A soft tissue defect repair system for approximating defects, such as defects in the annulus fibrosus of an intervertebral disc, includes a cannulated rod through which is disposed a suture retrieval device. A strand of suture includes a locking or ratcheting knot pre-tied around the outside of the cannulated rod and a free end that is guided in and out of the soft tissue. A knot pusher fits around the cannulated rod, which is used to push the knot off of the cannulated rod after the stitching of the tissue is accomplished. The defect is approximated by tensioning the free end. Various suturing methods or patterns are disclosed for defect approximation.

Abstract translation: 用于近似缺陷的软组织缺损修复系统，例如椎间盘纤维环中的缺陷，包括插管杆，通过该插管杆设置缝合线取出装置。 一股缝合线包括预先束缚在插管杆的外侧的锁定或棘轮结，以及引导进出软组织的自由端。 一个结推动器围绕插管杆，用于在组织的缝合完成之后将结从推杆上推出。 通过张紧自由端近似缺陷。 公开了各种缝合方法或图案用于缺陷近似。

公开(公告)号：US20080131932A1

公开(公告)日：2008-06-05

申请号：US11848213

申请日：2007-08-30

Applicant: Hans De Nobel ,  David A. Estell ,  Wei Liu ,  Scott D. Power ,  Brian Schmidt ,  Huaming Wang

Inventor： Hans De Nobel ,  David A. Estell ,  Wei Liu ,  Scott D. Power ,  Brian Schmidt ,  Huaming Wang

IPC: C07H21/04 ,  C12P1/00 ,  C12N15/00 ,  C12N15/74 ,  C12N5/02 ,  C12P21/04

CPC classification number: C12N15/80 ,  C07K14/811

Abstract: Described herein are protease inhibitors, variants thereof and methods for their production.

公开(公告)号：US20070050538A1

公开(公告)日：2007-03-01

申请号：US11510254

申请日：2006-08-24

Applicant: J. Northcutt ,  James Hanko ,  Brian Schmidt

Inventor： J. Northcutt ,  James Hanko ,  Brian Schmidt

IPC: G06F12/00

CPC classification number: G06F12/00 ,  G06F3/0605 ,  G06F3/0626 ,  G06F3/0635 ,  G06F3/0664 ,  G06F3/067 ,  G06F3/0689 ,  G06F12/10 ,  G06F2212/262 ,  H04L49/35

Abstract: A method and system for providing advanced storage features using commodity, consumer-level storage devices is provided. The advanced storage system is a component that is connected between the computer system and one or more physical disk drives. The host interface of the advanced storage system presents itself to the computer system as a virtual disk drive that implements the commands of consumer-level storage hardware that are familiar to the host controller of the computer system. Similarly, the storage device interface of the advanced storage system presents itself to one or more disk drives as a consumer-level host controller, regardless of the actual topology of the physical storage devices that are connected. This system provides a simple way for a user to combine low-cost, consumer-level hardware to add advanced storage features to a computer system.

Abstract translation: 提供了一种使用商品，消费者级存储设备提供高级存储特征的方法和系统。 高级存储系统是连接在计算机系统和一个或多个物理磁盘驱动器之间的组件。 高级存储系统的主机接口将自身呈现给作为虚拟磁盘驱动器的计算机系统，该虚拟磁盘驱动器实现计算机系统的主机控制器熟悉的消费者级存储硬件的命令。 类似地，高级存储系统的存储设备接口将其自身呈现为一个或多个磁盘驱动器作为消费者级主机控制器，而不管连接的物理存储设备的实际拓扑如何。 该系统为用户提供了一种简单的方法，将低成本，消费者级硬件组合到计算机系统中添加高级存储功能。

公开(公告)号：US20060009808A1

公开(公告)日：2006-01-12

申请号：US11226954

申请日：2005-09-15

Applicant: Brian Schmidt ,  Michael O'Phelan ,  James Poplett ,  Robert Tong

Inventor： Brian Schmidt ,  Michael O'Phelan ,  James Poplett ,  Robert Tong

IPC: A61N1/18 ,  H01G4/30

CPC classification number: A61N1/3968 ,  H01G9/10 ,  Y10T29/417 ,  Y10T29/435

Abstract: An exemplary capacitor has a capacitor stack positioned in a case with a conductor positioned between the case and a lid. In one embodiment the conductor is positioned between the lid and an upper rim of the case and is welded to the lid and case. In one aspect, a capacitor constructed with round wire connectors for interconnecting anode and cathode layers. In one aspect, a configuration for electrically connecting a terminal wire to a capacitor case in which an end of the wire is attached to the case in end-on fashion. The terminal wire may have an expanded end for attaching to the capacitor case in a manner that minimizes the effect on the height profile of the case.

Abstract translation: 示例性的电容器具有位于外壳中的电容器堆叠，导体位于外壳和盖之间。 在一个实施例中，导体位于盖和壳体的上边缘之间，并且焊接到盖和壳体。 在一个方面，一种由用于互连阳极和阴极层的圆形线连接器构成的电容器。 一方面，一种用于将端子线电连接到电容器壳体的结构，其中电线的端部以端到端的方式附接到壳体。 端子线可以具有用于以最小化对壳体的高度分布的影响的方式附接到电容器壳体的扩展端。

公开(公告)号：US20050202535A1

公开(公告)日：2005-09-15

申请号：US10984514

申请日：2004-11-08

Applicant: Katherine Collier ,  Grant Ganshaw ,  Hans De Nobel ,  Scott Power ,  Anita Van Kimmenade ,  Marc Kolkman ,  Jeffrey Miller ,  Brian Schmidt ,  Gudrun Vogtentanz ,  David Estell

Inventor： Katherine Collier ,  Grant Ganshaw ,  Hans De Nobel ,  Scott Power ,  Anita Van Kimmenade ,  Marc Kolkman ,  Jeffrey Miller ,  Brian Schmidt ,  Gudrun Vogtentanz ,  David Estell

IPC: A61K38/08 ,  A61K38/54 ,  A61K38/55 ,  C07H21/04 ,  C07K7/06 ,  C07K14/81 ,  C12N1/21 ,  C12N9/99 ,  C12N15/62 ,  C12N15/74 ,  C12P21/06

CPC classification number: C07K14/81 ,  A61K38/00 ,  C07K7/06 ,  C07K14/811 ,  C07K2319/00 ,  C12N15/62

Abstract: The present invention provides compositions and methods related to expression of protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the protease inhibitors.

Abstract translation: 本发明提供了与细菌种中的蛋白酶抑制剂及其变体的表达相关的组合物和方法。 本发明进一步提供融合核酸，载体，融合多肽以及获得蛋白酶抑制剂的方法。

公开(公告)号：US10022122B2

公开(公告)日：2018-07-17

申请号：US12995758

申请日：2009-06-08

Applicant: Wamis Singhatat ,  James Talbot ,  Michael Keane ,  Brian Schmidt ,  Mark Reichen

Inventor： Wamis Singhatat ,  James Talbot ,  Michael Keane ,  Brian Schmidt ,  Mark Reichen

IPC: A61B17/04 ,  A61B17/00 ,  A61B17/08

Abstract: The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.