公开(公告)号：US06854167B2

公开(公告)日：2005-02-15

申请号：US10315409

申请日：2002-12-09

申请人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  Curtis Brian Williamson

发明人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  Curtis Brian Williamson

IPC分类号： D02J3/02

CPC分类号： D02J3/02 ,  D02G1/162 ,  D02J1/08

摘要： A process for forming a continuous filament yarn having the surface tactile character of a spun yarn. The process includes passing the cohesive yarn structure through the interior of a rotating sleeve member disposed in surrounding relation to the cohesive yarn structure. The rotating sleeve member includes an abrasive inner surface of diameter greater than the cohesive yarn structure and is adapted to contact the exterior surface of the cohesive yarn structure such that at least a portion of the elongate filaments disposed at the exterior of the cohesive yarn structure are broken. Terminal ends of the broken filaments define an arrangement of outwardly projecting hairs at discrete locations disposed substantially around the circumference of the cohesive yarn structure. An apparatus for carrying out the process is also provided.

公开(公告)号：US20240068882A1

公开(公告)日：2024-02-29

申请号：US17893345

申请日：2022-08-23

申请人： Shu S. Wang ,  David A. Lawrence ,  Michael Barkey

发明人： Shu S. Wang ,  David A. Lawrence ,  Michael Barkey

IPC分类号： G01K7/16 ,  B60R16/03 ,  B60W20/50

CPC分类号： G01K7/16 ,  B60R16/03 ,  B60W20/50 ,  B60W2510/0676 ,  B60W2510/068 ,  B60W2510/087 ,  B60W2520/10 ,  B60W2555/20

摘要： A system and method of controlling a powertrain to protect a high voltage cable by determining a temperature characteristic for a busbar, determining a temperature characteristic adjacent to a component, and determining a current through the high voltage cable. Thereafter, the method reduces an operating characteristic of the powertrain based on the temperature characteristic for the busbar, the temperature characteristic adjacent to the component, and the current.

公开(公告)号：US08198033B2

公开(公告)日：2012-06-12

申请号：US12308542

申请日：2007-06-20

申请人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

发明人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/574 ,  G01N33/00

CPC分类号： G01N33/574 ,  G01N2510/00

摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.

摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。

公开(公告)号：US07127784B2

公开(公告)日：2006-10-31

申请号：US11058478

申请日：2005-02-15

申请人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  C. Brian Williamson

发明人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  C. Brian Williamson

IPC分类号： D02J3/02

CPC分类号： D02G3/32 ,  D02G3/34 ,  D02J3/02 ,  Y10T428/2913

摘要： A process for forming a continuous filament yarn having the surface tactile character of a spun yarn. The process includes passing the cohesive yarn structure through the interior of a rotating sleeve member disposed in surrounding relation to the cohesive yarn structure. The rotating sleeve member includes an abrasive inner surface of diameter greater than the cohesive yarn structure and is adapted to contact the exterior surface of the cohesive yarn structure such that at least a portion of the elongate filaments disposed at the exterior of the cohesive yarn structure are broken. Terminal ends of the broken filaments define an arrangement of outwardly projecting hairs at discrete locations disposed substantially around the circumference of the cohesive yarn structure. An apparatus for carrying out the process is also provided.

摘要翻译： 用于形成具有细纱的表面触觉特性的连续长丝纱的方法。 该方法包括使粘性纱线结构通过围绕与内聚纱结构相关的旋转套筒部件的内部。 所述旋转套筒构件包括直径大于所述内聚纱结构的研磨内表面，并且适于接触所述粘性纱线结构的外表面，使得设置在所述粘性纱线结构外部的细长丝的至少一部分为 破碎。 断丝的终端限定了基本上围绕着粘性纱线结构的圆周设置的离散位置的向外突出的毛发的布置。 还提供了一种用于执行该过程的装置。

公开(公告)号：US20200332737A1

公开(公告)日：2020-10-22

申请号：US16387677

申请日：2019-04-18

申请人： Ethan E Bayer ,  Jonathan D. Stoffer ,  David A. Lawrence ,  William P. Attard ,  Tyler Tutton

发明人： Ethan E Bayer ,  Jonathan D. Stoffer ,  David A. Lawrence ,  William P. Attard ,  Tyler Tutton

IPC分类号： F02D41/22 ,  F02D41/14 ,  F02D41/00 ,  G07C5/08

摘要： A low speed pre-ignition detection, mitigation, and driver notification system and method utilize a controller to analyze a knock signal from a knock sensor to detect LSPI knock of the engine and in response to detecting the LSPI knock, enrich a fuel/air ratio of the engine and limit a torque output of the engine to a level that is less than a maximum torque output of the engine, and when enriching the fuel/air ratio of the engine and limiting the torque output of the engine does not mitigate the LSPI knock, output at least one message for a driver of the vehicle instructing the driver to take remedial action to mitigate the LSPI knock.

公开(公告)号：US20110244473A1

公开(公告)日：2011-10-06

申请号：US12308542

申请日：2007-06-20

申请人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

发明人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/574 ,  G01N2510/00

摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.

摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。

公开(公告)号：US5985658A

公开(公告)日：1999-11-16

申请号：US970363

申请日：1997-11-14

申请人： Robert James Colinas ,  Anne Catherine Walsh ,  David A. Lawrence

发明人： Robert James Colinas ,  Anne Catherine Walsh ,  David A. Lawrence

IPC分类号： C12N5/00 ,  C12N5/06 ,  G01N33/50 ,  C12N5/02 ,  G01N33/53 ,  G01N33/536

CPC分类号： G01N33/5005

摘要： The invention provides a method for separating target cells from a plurality of cells which is based on a reversible high affinity interaction between two molecules. The method comprises: forming a target cell/cell binding reagent/first molecule/second molecule/solid support complex, wherein the cell binding reagent is specific for target cells present within a plurality of cells and wherein the first molecule reversibly binds to the second molecule; removing non-target cells of the plurality of cells not attached to the solid support; and reversing the first molecule binding to the second molecule, thereby releasing the target cells as separate cells from the plurality of cells.

摘要翻译： 本发明提供了一种基于两个分子之间的可逆高亲和力相互作用的从多个细胞中分离靶细胞的方法。 该方法包括：形成靶细胞/细胞结合试剂/第一分子/第二分子/固体支持复合物，其中所述细胞结合试剂对存在于多个细胞内的靶细胞是特异性的，并且其中所述第一分子可逆地结合到所述第二分子 ; 去除未连接到固体支持物上的多个细胞的非靶细胞; 并且使与第二分子结合的第一分子反转，从而从多个细胞释放作为分离的细胞的靶细胞。

公开(公告)号：US4859613A

公开(公告)日：1989-08-22

申请号：US929937

申请日：1986-11-12

申请人： David A. Lawrence

发明人： David A. Lawrence

IPC分类号： G01N33/574 ,  G01N33/68 ,  G01N33/74

CPC分类号： G01N33/68 ,  G01N33/574 ,  G01N33/743 ,  Y10S435/948 ,  Y10S530/806 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/868

摘要： Monoclonal antibodies specifically immunologically reactive to thiol-modified glutathione and hybridoma cell lines producing such monoclonal antibodies. A method of producing antibodies specifically immunologically reactive with reduced glutathione by immunizing an animal using a thiol-modified glutathione, for example, a glutathione-N-ethylmaleimide-keyhole limpet hemocyanin conjugate. A method of utilizing the antibodies produced to quantitate the amount of reduced glutathione in a biological sample, to monitor glutathione-associated conditions, to monitor the formation of normal metabolic intermediates and to monitor the detoxification of foreign compounds.

摘要翻译： 与硫醇修饰的谷胱甘肽和产生这种单克隆抗体的杂交瘤细胞系特异性免疫反应的单克隆抗体。 通过使用硫醇修饰的谷胱甘肽，例如谷胱甘肽-N-乙基马来酰亚胺 - 钥孔血蓝蛋白缀合物免疫动物，产生与还原型谷胱甘肽特异性免疫反应的抗体的方法。 一种利用产生的抗体来定量生物样品中还原型谷胱甘肽的量，监测谷胱甘肽相关病症，监测正常代谢中间体形成和监测外源化合物解毒的方法。

公开(公告)号：US20190136747A1

公开(公告)日：2019-05-09

申请号：US15805335

申请日：2017-11-07

申请人： Shuonan Xu ,  David A. Lawrence ,  Ethan E. Bayer

发明人： Shuonan Xu ,  David A. Lawrence ,  Ethan E. Bayer

IPC分类号： F02B33/40 ,  F02D9/02 ,  F02D41/00 ,  F02B37/18 ,  F02D13/02 ,  F02D11/10 ,  F02D41/14

CPC分类号： F02B33/40 ,  F02B37/18 ,  F02B37/183 ,  F02D9/02 ,  F02D11/105 ,  F02D13/0261 ,  F02D41/0007 ,  F02D41/1446 ,  F02D41/1454 ,  F02D2041/001 ,  F02D2041/141 ,  F02D2041/1434 ,  F02D2200/021 ,  F02D2200/023 ,  F02D2200/0402 ,  F02D2200/0411 ,  F02D2200/0802 ,  F02D2200/101 ,  F02D2250/22 ,  Y02T10/144

摘要： Techniques for setting a boost target for a turbocharged engine comprise (i) operating the engine in a scavenging mode such that opening of intake and exhaust valves of cylinders of the engine overlap and (ii) while transitioning the engine in/out of the scavenging mode: determining an engine torque request, creating a torque reserve by setting independent targets for throttle inlet pressure (TIP) and intake manifold absolute pressure (MAP), determining a target TIP based on a target total air charge, engine speed, and a previously-determined target engine volumetric efficiency (VE), controlling a wastegate valve based on the target TIP, determining a target MAP based on the engine torque request, and controlling a throttle valve based on the target MAP. During steady-state scavenging operation, the controller calculates a conventional target TIP based on the engine torque request and controls the wastegate valve based on the conventionally calculated target TIP.

公开(公告)号：US20160076471A1

公开(公告)日：2016-03-17

申请号：US14851033

申请日：2015-09-11

申请人： Ethan E. Bayer ,  Ayman Ismail ,  David A. Lawrence

发明人： Ethan E. Bayer ,  Ayman Ismail ,  David A. Lawrence

IPC分类号： F02D41/00 ,  F02D13/02 ,  F02B75/22 ,  F02D41/14

CPC分类号： F02D41/0082 ,  F01L1/34 ,  F01L2013/111 ,  F01L2800/11 ,  F01L2820/041 ,  F01L2820/042 ,  F02B75/22 ,  F02D13/0226 ,  F02D13/0238 ,  F02D41/0085 ,  F02D41/1405 ,  F02D41/1443 ,  F02D41/1454 ,  F02D41/2451 ,  F02D41/2454 ,  F02D2041/001 ,  F02D2200/0411 ,  Y02T10/18

摘要： An engine bank-to-bank airflow balancing technique includes calculating current and offset volumetric efficiencies of the engine and calculating a slope representing (i) a difference between the offset and current volumetric efficiencies and (ii) a difference between offset and current intake camshaft positions. Based on the respective exhaust gas oxygen concentrations, the technique involves calculating a volumetric efficiency correction corresponding to each cylinder bank and based on the slope and the volumetric efficiency corrections, calculating target intake camshaft position shifts. The technique further involves controlling offsets of the intake camshafts based on the target intake camshaft position shifts. After a predetermined number of target intake camshaft position shifts are determined and stored with respect to various combinations of engine speed and a ratio of intake manifold pressure to barometric pressure, final intake camshaft position shifts may be determined and utilized when determining the intake camshaft positions.

摘要翻译： 发动机库对空气流平衡技术包括计算发动机的当前和偏移体积效率并计算斜率，其表示（i）偏移和当前体积效率之间的差异，以及（ii）偏置和当前进气凸轮轴位置之间的差异 。 基于相应的废气氧浓度，该技术涉及计算对应于每个气缸组的体积效率校正，并且基于斜率和体积效率校正，计算目标进气凸轮轴位置偏移。 该技术还涉及基于目标进气凸轮轴位置偏移来控制进气凸轮轴的偏移。 在相对于发动机转速和进气歧管压力与大气压力的比例的各种组合来确定和存储预定数量的目标进气凸轮轴位置偏移之后，可以在确定进气凸轮轴位置时确定和利用最终进气凸轮轴位置偏移。