公开(公告)号：US07647836B2

公开(公告)日：2010-01-19

申请号：US11748803

申请日：2007-05-15

Applicant: David O'Brien ,  Christophe Courcimault ,  Liang You ,  Mark Allen ,  Michael Fonseca ,  Florent Cros

Inventor： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Mark Allen ,  Michael Fonseca ,  Florent Cros

IPC: G01L7/00

CPC classification number: G01L9/0075 ,  G01L9/0042 ,  G01L9/0055 ,  Y10T29/49002

Abstract: A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Abstract translation: 压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封，同时保持与其他设备通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境，例如 体内植入和体内使用。 另外，采用新的制造方法构造传感器。

公开(公告)号：US20070225676A1

公开(公告)日：2007-09-27

申请号：US11805096

申请日：2007-05-21

Applicant: Mark Prausnitz ,  Mark Allen ,  Inder-Jeet Gujral

Inventor： Mark Prausnitz ,  Mark Allen ,  Inder-Jeet Gujral

IPC: A61M31/00

CPC classification number: A61M37/0015 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/150984 ,  A61B17/205 ,  A61B2090/0814 ,  A61M5/422 ,  A61M2037/0023 ,  A61M2037/003 ,  B33Y80/00

Abstract: Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.

Abstract translation: 提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。 所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。 储存器可以由可变形的，优选弹性的材料形成。 该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

公开(公告)号：US20070096715A1

公开(公告)日：2007-05-03

申请号：US11613645

申请日：2006-12-20

Applicant: James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

Inventor： James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

IPC: G01R23/12

CPC classification number: G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

Abstract: The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

公开(公告)号：US20060245140A1

公开(公告)日：2006-11-02

申请号：US11452592

申请日：2006-06-15

Applicant: Andrew Hunt ,  Mark Allen

Inventor： Andrew Hunt ,  Mark Allen

IPC: H01G5/00

CPC classification number: H01G5/0132 ,  H01G5/013

Abstract: Capacitors 10, 20, 40, 50, 70, 80) having a fluid dielectric material that is transported or undergoes a phase change are disclosed. The dielectric medium change results in a change in the total dielectric constant of the material between the electrodes (12, 14, 72, 74, 81, 82), thus changing the capacitance of the capacitors. Transporting or phase changing the dielectric fluids into and out of a the electric field of the capacitor, changes the effective dielectric constant and the capacitance of the capacitor.

Abstract translation: 公开了具有被输送或经历相变的流体介电材料的电容器10,20,40,50,70,80,80）。 电介质变化导致电极（12,14,72,74,81,82）之间的材料的总介电常数的变化，从而改变电容器的电容。 将电介质流体输送或相位改变为电容器的电场，从而改变电容器的有效介电常数和电容。

公开(公告)号：US20060203482A1

公开(公告)日：2006-09-14

申请号：US11357405

申请日：2006-02-21

Applicant: Mark Allen ,  David Allen

Inventor： Mark Allen ,  David Allen

IPC: B60Q1/26

CPC classification number: H01L33/56 ,  F21S4/10 ,  F21V5/04 ,  F21V15/01 ,  F21V19/0005 ,  F21V23/001 ,  F21V31/005 ,  F21V31/04 ,  F21W2121/00 ,  F21W2121/04 ,  F21Y2115/10 ,  H01L33/58 ,  H01L33/62 ,  H01L2224/48247 ,  H01L2924/181 ,  H01L2924/30107 ,  H01L2924/3011 ,  H05B33/0803 ,  H05B33/0809 ,  H05B33/0821 ,  Y02B20/383 ,  Y10S362/80 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

Abstract: A jacketed light emitting diode assembly is provided, which includes a light emitting diode including a set of positive and negative contacts, and a lens body containing a semiconductor chip and end portions of the contacts. An electrical wire set of first and second electrical wires are connected to the positive contact and the negative contact, respectively. A light transmissive cover receives the lens body, and has an opening through which at least one of the contact set and the electrical wire set passes. An integrally molded plastic jacket at the opening of the light transmissive cover provides a seal at the opening against moisture and airborne contaminants. A waterproof light string including one or more of the jacketed light emitting diode assemblies is also provided, as are related methods.

公开(公告)号：US20060183344A1

公开(公告)日：2006-08-17

申请号：US10550215

申请日：2004-03-18

Applicant: Gary Escher ,  Mark Allen

Inventor： Gary Escher ,  Mark Allen

IPC: H01L21/31 ,  H01L21/469

CPC classification number: H01J37/32477 ,  C23C16/40 ,  H01J37/32559

Abstract: In order to mitigate erosion of exposed processing elements in a processing system by the process and any subsequent contamination of the substrate in the processing system, processing elements exposed to the process are coated with a protective barrier. The protective barrier comprises a protective layer that is resistant to erosion by the plasma, and a bonding layer that improves the adhesion of the protective layer to the processing element to mitigate possible process contamination by failure of the protective layer.

Abstract translation: 为了通过该方法减轻处理系统中暴露的处理元件的侵蚀以及处理系统中衬底的任何后续污染，暴露于该工艺的处理元件被涂覆有保护性屏障。 保护屏障包括耐受等离子体侵蚀的保护层，以及粘合层，其改善了保护层与处理元件的粘合性，以通过保护层的故障来减轻可能的工艺污染。

公开(公告)号：US20060129978A1

公开(公告)日：2006-06-15

申请号：US11350448

申请日：2006-02-06

Applicant: Pedram Abrari ,  Mark Allen

Inventor： Pedram Abrari ,  Mark Allen

IPC: G06F9/44

CPC classification number: G06F8/10 ,  G06F8/34 ,  G06Q10/06 ,  Y02P90/86

Abstract: Methods and apparatus, including computer program products, for interacting with a user to define business rules in a declarative manner. The invention operates to display a set of business rules as editable conditions and editable actions, the conditions and the actions being linked to each other by a combination of editable if-values and editable then-values.

Abstract translation: 方法和装置，包括计算机程序产品，用于与用户交互以声明方式定义业务规则。 本发明用于将一组业务规则显示为可编辑条件和可编辑动作，条件和动作通过可编辑if值和可编辑then值的组合彼此链接。

公开(公告)号：US07047143B2

公开(公告)日：2006-05-16

申请号：US10889916

申请日：2004-07-13

Applicant: Mark Allen ,  Wayne J. Book ,  Imme Ebert-Uphoff ,  Ari Glezer ,  David W. Rosen ,  Jaroslaw R. Rossignac

Inventor： Mark Allen ,  Wayne J. Book ,  Imme Ebert-Uphoff ,  Ari Glezer ,  David W. Rosen ,  Jaroslaw R. Rossignac

IPC: G06F15/00

CPC classification number: G06F3/016 ,  B33Y80/00

Abstract: A system and method for controlling the surface and/or volume of a digital clay device is provided. One embodiment, among others, is a method comprising the following steps: determining a desired position of a skeleton structure portion residing in the digital clay device, determining a volumetric change of fluid residing in a fluid cell, the determined volumetric change corresponding to the determined desired position of the skeleton structure portion, opening a valve so that the fluid flows through the valve thereby causing the determined volumetric change of the fluid, and adjusting a position of the skeleton structure portion corresponding to the desired position of the skeleton structure portion, the position adjustment caused by a force generated by the fluid cell on the skeleton structure portion when the volume of the fluid cell changes in response to the determined volumetric change of the fluid residing in the fluid cell.

Abstract translation: 提供了一种用于控制数字粘土装置的表面和/或体积的系统和方法。 一个实施例，其中包括以下步骤：确定驻留在数字粘土装置中的骨架结构部分的期望位置，确定驻留在流体池中的流体的体积变化，所确定的体积变化对应于所确定的 骨架结构部分的所需位置，打开阀，使得流体流过阀门，从而导致确定的流体体积变化，并且调整与骨架结构部分的期望位置对应的骨架结构部分的位置， 当流体池的体积响应于确定的存在于流体池中的流体的体积变化而改变时，由骨架结构部分上的流体池产生的力引起的位置调整。

公开(公告)号：US20050137531A1

公开(公告)日：2005-06-23

申请号：US10856691

申请日：2004-05-28

Applicant: Mark Prausnitz ,  Mark Allen ,  Sebastian Henry ,  Devin McAllister ,  Donald Ackley ,  Thomas Jackson

Inventor： Mark Prausnitz ,  Mark Allen ,  Sebastian Henry ,  Devin McAllister ,  Donald Ackley ,  Thomas Jackson

IPC: A61B5/00 ,  A61B5/15 ,  A61B17/20 ,  A61M5/42 ,  A61M37/00 ,  A61M5/00

CPC classification number: A61M37/0015 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150984 ,  A61B5/151 ,  A61B17/205 ,  A61M5/422 ,  A61M5/425 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B33Y80/00

Abstract: Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.

Abstract translation: 提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。 装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔 或（4）这些方法的任何组合。 在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。 在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。

公开(公告)号：USD455500S1

公开(公告)日：2002-04-09

申请号：US29121960

申请日：2000-04-18

Applicant: Mark Allen

Designer： Mark Allen