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公开(公告)号:US08513242B2
公开(公告)日:2013-08-20
申请号:US13139009
申请日:2009-12-11
申请人: Phoebe Chiang , Shomir Ghosh
发明人: Phoebe Chiang , Shomir Ghosh
IPC分类号: A61K31/535 , A61K31/505
CPC分类号: C07D403/14 , C07D239/12 , C07D239/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04
摘要: Disclosed herein are pyrimidinyl compounds that are contemplated to be modulators of cystic fibrosis transmembrane regulators (CFTR), and methods of making and using same. Also provided are pharmaceutical compositions and methods of treating disorders associated with cystic fibrosis transmembrane regulators, such as airway inflammation, cystic fibrosis, and the like.
摘要翻译: 本文公开了被认为是囊性纤维化跨膜调节剂(CFTR)的调节剂的嘧啶基化合物及其制备和使用方法。 还提供了治疗与囊性纤维化跨膜调节剂相关的病症的药物组合物和方法,例如气道炎症,囊性纤维变性等。
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公开(公告)号:US08309685B2
公开(公告)日:2012-11-13
申请号:US12497103
申请日:2009-07-02
申请人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
发明人: Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
IPC分类号: C07K5/08
CPC分类号: A61K47/48246 , A61K38/00 , A61K38/005 , A61K38/06 , A61K38/12 , A61K47/64 , C07D401/12 , C07K5/0202 , C07K5/06165 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C12N9/506 , C12N9/96 , C12Y304/00
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译: 本发明提供化合物,其药学上可接受的组合物及其使用方法。
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公开(公告)号:US20120214807A1
公开(公告)日:2012-08-23
申请号:US13281482
申请日:2011-10-26
申请人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: A61K31/5377 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/454 , A61K31/453 , A61K31/4439 , C07D471/04 , C07D405/14 , C07D413/14 , C07D405/04 , C07D409/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/5025
CPC分类号: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供通式I的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US20120046311A1
公开(公告)日:2012-02-23
申请号:US13245436
申请日:2011-09-26
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A61K31/4353 , A61P19/02 , A61P9/10 , A61P3/10 , A61P29/00 , A61P25/00 , A61P1/00 , A61P37/08 , A61P11/06 , C07D491/044 , A61P17/06
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US20110230494A1
公开(公告)日:2011-09-22
申请号:US13018624
申请日:2011-02-01
IPC分类号: A61K31/506 , C07D405/14 , C07D401/12 , C07D403/12 , C07D239/47 , A61K31/505 , C07D239/48 , A61P29/00 , A61P19/08 , A61P35/00 , A61P9/00 , A61P11/06 , A61P37/08 , A61P25/28 , A61P37/06 , A61P3/00
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/47 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C12N9/12 , C12Y207/10
摘要: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译: 本发明提供化合物,其药学上可接受的组合物及其使用方法。
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公开(公告)号:US07982036B2
公开(公告)日:2011-07-19
申请号:US12253424
申请日:2008-10-17
IPC分类号: C07D239/02
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D239/47 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C12N9/12 , C12Y207/10
摘要: The present invention provides compounds of formula I wherein Ring A, Ring B, m, Rx, Ry, W and R1 are as defined herein, pharmaceutically acceptable salts and compositions thereof, and methods of using the same.
摘要翻译: 本发明提供式I化合物,其中环A,环B,m,Rx,Ry,W和R 1如本文所定义,其药学上可接受的盐和组合物,及其使用方法。
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公开(公告)号:US20100331298A1
公开(公告)日:2010-12-30
申请号:US12747106
申请日:2008-12-10
申请人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人: Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号: A61K31/538 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D417/06 , C07D413/14 , A61K31/4709 , A61K31/453 , A61K31/454 , A61K31/4725 , A61K31/416 , A61K31/423 , A61K31/496 , A61P19/02 , A61P29/00 , A61P17/06 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/00 , A61P3/04
CPC分类号: C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要: Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译: 本文描述了趋化因子受体拮抗剂,特别是作为趋化因子CCR2受体的拮抗剂的式(I)化合物,包括药物组合物及其用于治疗或预防与单核细胞积聚,淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号:US20100324035A1
公开(公告)日:2010-12-23
申请号:US12747109
申请日:2008-12-11
申请人: Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
发明人: Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号: A61K31/538 , A61K31/501 , A61K31/4375 , C07D471/02
CPC分类号: C07D471/04
摘要: Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译: 本文描述了趋化因子受体拮抗剂,特别是作为趋化因子CCR2受体的拮抗剂的式(I-A)化合物,包括药物组合物及其用于治疗或预防与单核细胞积聚,淋巴细胞积聚或白细胞积聚相关的疾病的用途。
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公开(公告)号:US20100249174A1
公开(公告)日:2010-09-30
申请号:US12765070
申请日:2010-04-22
IPC分类号: A61K31/4353 , C07D491/044 , A61P29/00 , A61P9/10 , A61P3/10 , A61P17/06 , A61P37/00 , A61P37/08 , A61P37/06 , A61P11/06
CPC分类号: C07D491/044 , C07D491/04
摘要: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
摘要翻译: 本发明提供具有下式的化合物:其中R1是卤素。 本发明还提供包含该化合物的组合物,以及治疗疾病或病症的方法,所述疾病或病症包括向有需要的受试者施用一种或多种化合物。 所公开的化合物具有CCR1拮抗剂活性。
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公开(公告)号:US20090281081A1
公开(公告)日:2009-11-12
申请号:US12436271
申请日:2009-05-06
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A61K31/4523 , C07D211/22 , C07D405/06 , C07D409/06 , C07D401/06 , C07D413/14 , C07D491/044 , A61K31/451 , A61K31/4535 , A61K31/4353 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/537 , A61K31/438 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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