公开(公告)号：US11441130B2

公开(公告)日：2022-09-13

申请号：US15319272

申请日：2015-06-16

Applicant: GENOMATICA, INC.

Inventor： Baolong Zhu ,  Andreas W. Schirmer ,  Cindy Chang

IPC: C12N9/02 ,  C12P7/6409

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US11186854B2

公开(公告)日：2021-11-30

申请号：US16736405

申请日：2020-01-07

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Mathew A. Rude ,  Shane A. Brubaker

IPC: C12N9/88 ,  C12P7/64 ,  C12N9/02 ,  C10L1/02 ,  C12P7/04 ,  C12P7/24 ,  C12P5/02

Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

公开(公告)号：US20210071212A1

公开(公告)日：2021-03-11

申请号：US16915454

申请日：2020-06-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N9/02 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52 ,  C12N9/04

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US10711288B2

公开(公告)日：2020-07-14

申请号：US14897285

申请日：2014-06-16

Applicant: GENOMATICA, INC.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N1/21 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/10 ,  C12N9/06 ,  C12N15/53 ,  C12N15/54 ,  C12N9/60 ,  C07K19/00 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US12188068B2

公开(公告)日：2025-01-07

申请号：US17229543

申请日：2021-04-13

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P7/42 ,  C12P7/44 ,  C12P17/04

Abstract: The present disclosure relates to chemo-enzymatic processes for the preparation of lactones (including, e.g., macrolactones, γ-lactones, and δ-lactones) and/or macrocyclic ketones, which are compounds of industrial value, for example, for use as fragrance ingredients. The chemo-enzymatic processes combine the in vivo microbial production of fatty acid derivatives and the subsequent ex vivo synthetic transformation of the fatty acid derivatives to provide the lactones and macrocyclic ketones.

公开(公告)号：US11060099B2

公开(公告)日：2021-07-13

申请号：US15650285

申请日：2017-07-14

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Andreas W. Schirmer ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Bernardo M. Da Costa ,  Zhihao Hu ,  Kevin Holden ,  Noah Helman

IPC: C12N1/21 ,  C12P7/64 ,  C07K14/195 ,  C07K14/245 ,  C12N9/16 ,  C12N15/70 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N9/00 ,  C12P7/04

Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.

公开(公告)号：US20210071207A1

公开(公告)日：2021-03-11

申请号：US16889211

申请日：2020-06-01

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Noah HELMAN ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel RAMOS-SOLIS ,  Elizabeth Clarke

IPC: C12P7/18 ,  C12N9/00 ,  C12N9/16 ,  C12N15/52

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.