公开(公告)号：US20180327437A1

公开(公告)日：2018-11-15

申请号：US16011055

申请日：2018-06-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Thomas Butler ,  Aesop Cho ,  Benjamin R. Graetz ,  Choung U. Kim ,  Samuel E. Metobo ,  Oliver L. Saunders ,  Andrew W. Waltman ,  Jie Xu ,  Lijun Zhang

IPC: C07H1/00 ,  C07H19/23

CPC classification number: C07H1/00 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  C07H19/23

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

公开(公告)号：USRE46762E1

公开(公告)日：2018-03-27

申请号：US15288271

申请日：2016-10-07

Applicant: Gilead Sciences, Inc.

Inventor： Thomas Butler ,  Aesop Cho ,  Choung U. Kim ,  Jay P. Parrish ,  Oliver L. Saunders ,  Lijun Zhang

IPC: A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H7/06 ,  C07H19/23 ,  C07D487/04

CPC classification number: C07H19/23 ,  C07D487/04

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

公开(公告)号：US20170210770A1

公开(公告)日：2017-07-27

申请号：US15402857

申请日：2017-01-10

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US09457035B2

公开(公告)日：2016-10-04

申请号：US14178237

申请日：2014-02-11

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/04 ,  A61K31/675 ,  A61K31/662 ,  C07F9/6561 ,  C07H19/00 ,  A61K45/06 ,  C07H19/20

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130090302A1

公开(公告)日：2013-04-11

申请号：US13626687

申请日：2012-09-25

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. BOOJAMRA ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/20

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20130090299A1

公开(公告)日：2013-04-11

申请号：US13653982

申请日：2012-10-17

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07F9/6561 ,  A61K45/06 ,  A61K31/675

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。