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公开(公告)号：US11932634B2
公开(公告)日：2024-03-19
申请号：US17845469
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04
CPC classification number: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07B2200/05
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20230060004A1
公开(公告)日：2023-02-23
申请号：US17845469
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/12 , C07D417/12 , C07D403/12 , C07D401/04 , C07D471/04 , C07D413/04 , C07D401/14
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20220340535A1
公开(公告)日：2022-10-27
申请号：US17171201
申请日：2021-02-09
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D267/20 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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公开(公告)号：US20170290827A1
公开(公告)日：2017-10-12
申请号：US15488035
申请日：2017-04-14
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila M. Zipfel
IPC: A61K31/498 , C07D403/14 , C07D241/36 , A61K31/401 , A61K31/10
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20160376261A1
公开(公告)日：2016-12-29
申请号：US15239422
申请日：2016-08-17
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/04 , C07D453/02 , C07D417/14 , C07D413/14 , C07D471/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 其中R1a，R1b，R2a，R2b，R3，R4a，R4b和R5如本文所述。
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Patent Agency Ranking
公开(公告)号：US20160362421A1
公开(公告)日：2016-12-15
申请号：US15188701
申请日：2016-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Britton Kenneth Corkey , Elfatih Elzein , Michael Graupe , Juan Guerrero , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Chandrasekar Venkataramani , Jeff Zablocki
IPC: C07D498/10 , C07D401/04 , C07D403/04 , C07D413/06 , C07D403/06 , C07D413/14 , C07D417/06 , C07D403/12 , C07D401/12 , C07D401/14 , C07D237/32 , C07D417/12 , C07D401/06 , C07D265/22 , C07D279/08 , C07D217/26 , C07D405/12 , C07D253/08
CPC classification number: C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Abstract translation: 其中Q，R 1，X 1，X 2，Y和R 2如本文所述，用于制备和使用化合物的方法以及含有该化合物的药物组合物。
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公开(公告)号：US09079901B2
公开(公告)日：2015-07-14
申请号：US14217011
申请日：2014-03-17
Applicant: Gilead Sciences, Inc.
Inventor： Tetsuya Kobayashi , Dmitry Koltun , Gregory Notte , Eric Parkhill , Jeff Zablocki
IPC: C07D401/14 , A61K31/437 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, R4, and R5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Abstract translation: 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中R 1，R 2，R 3，R 4和R 5如本文所述，用于制备和使用化合物的方法以及含有该化合物的药物组合物。
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公开(公告)号：US20140336190A1
公开(公告)日：2014-11-13
申请号：US14273147
申请日：2014-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D471/04 , C07D413/14 , C07D417/14 , C07D413/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 本申请涉及可用作抑制剂的化合物; 或其它可能调节含溴结构域的蛋白质（包括含有溴结构域的蛋白质4（BRD4））的活性，以及含有这些化合物的组合物和制剂，以及使用和制备这些化合物的方法。 化合物包括其中R1a，R1b，R2，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
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公开(公告)号：US12202842B2
公开(公告)日：2025-01-21
申请号：US18181116
申请日：2023-03-09
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , David W. Lin , Jonathan William Medley , Devan Naduthambi , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang , Qingming Zhu
IPC: C07D413/08 , A61K31/553 , A61K45/06 , A61P35/00 , C07D513/08 , C07D513/10 , C07D513/18 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/28
Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.
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公开(公告)号：US20240400568A1
公开(公告)日：2024-12-05
申请号：US18645837
申请日：2024-04-25
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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