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    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
    11.
    发明授权
    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis 有权

    公开(公告)号：US10808262B2

    公开(公告)日：2020-10-20

    申请号：US15039221

    申请日：2014-11-25

    Applicant: GENOMATICA, INC.

    Inventor： Robin E. Osterhout ,  Anthony P. Burgard ,  Priti Pharkya ,  Stefan Andrae

    IPC: C12N1/16 ,  C12N1/20 ,  C12P7/02 ,  C12P5/02 ,  C12P7/18 ,  C12N1/14 ,  C12P7/42 ,  C12P7/40 ,  C12N15/70 ,  C12N15/81 ,  C12P7/04 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

    Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

    Alcohol dehydrogenase variants
    16.
    发明授权
    Alcohol dehydrogenase variants 有权

    公开(公告)号：US10563180B2

    公开(公告)日：2020-02-18

    申请号：US15027169

    申请日：2014-10-03

    Applicant: Genomatica Inc.

    Inventor： Stefan Andrae ,  Michael Patrick Kuchinskas ,  Jingyi Li ,  Harish Nagarajan ,  Priti Pharkya

    IPC: C12N9/04 ,  C12P7/24

    Abstract: Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to formaldehyde or acetaldehyde, respectively, as compared to its unmodified counterpart. Nucleic acids encoding the non-natural alcohol dehydrogenases, as well as expression constructs including the nucleic acids, and engineered cells comprising the nucleic acids or expression constructs are described. Also described are engineered cells expressing a non-natural NAD+-dependent alcohol dehydrogenase, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.

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