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36 条记录 (耗时 0.024 秒)

    CHARACTERIZATION OF INDIVIDUAL POLYMER MOLECULES BASED ON MONOMER-INTERFACE INTERACTIONS
    11.
    发明申请
    CHARACTERIZATION OF INDIVIDUAL POLYMER MOLECULES BASED ON MONOMER-INTERFACE INTERACTIONS 审中-公开
    基于单体界面相互作用的个体聚合物分子的表征

    公开(公告)号：US20120160687A1

    公开(公告)日：2012-06-28

    申请号：US13186966

    申请日：2011-07-20

    申请人： Mark Akeson ,  Daniel Branton ,  George Church ,  David W. Deamer

    发明人： Mark Akeson ,  Daniel Branton ,  George Church ,  David W. Deamer

    IPC分类号： C07K1/26

    CPC分类号： C12Q1/6869 ,  G01N27/447 ,  G01N33/48721 ,  C12Q2565/631 ,  C12Q2565/607

    摘要： The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of a double-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acid polymer in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the single-stranded nucleic acid polymer passes through the channel so as to differentiate between nucleotide monomers that are hybridized to another nucleotide monomer before entering the channel and nucleotide monomers that are not hybridized to another nucleotide monomer before entering the channel.

    摘要翻译： 本发明涉及一种用于通过（1）在两个池之间提供两个独立的相邻的介质池和界面来检测核酸中的双链区域的方法，所述界面具有如此尺寸以允许顺序单体 单链核酸但不是双链核酸的单体通过从一个池到另一个池; （2）将核酸聚合物置于两个池中的一个中; 和（3）测量，因为单链核酸聚合物的每个核苷酸单体通过通道，以便在进入通道之前与另一个核苷酸单体杂交的核苷酸单体与未杂交的核苷酸单体区分 进入通道之前的另一种核苷酸单体。

    Modular molecular clasps and uses thereof
    16.
    发明申请
    Modular molecular clasps and uses thereof 审中-公开
    模块化分子钩扣及其用途

    公开(公告)号：US20070276129A1

    公开(公告)日：2007-11-29

    申请号：US11505630

    申请日：2006-08-17

    申请人： Carlo Rizzuto ,  Noubar Afeyan ,  Frank Lee ,  George Church ,  Ruchira Gupta ,  John Schwartz ,  Bin Zhang ,  Alexey Lugovskoy

    发明人： Carlo Rizzuto ,  Noubar Afeyan ,  Frank Lee ,  George Church ,  Ruchira Gupta ,  John Schwartz ,  Bin Zhang ,  Alexey Lugovskoy

    IPC分类号： C07K16/46

    CPC分类号： C12N15/62 ,  A61K38/00 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/60 ,  C07K2319/74 ,  G01N33/542

    摘要： The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.

    摘要翻译： 本发明提供了在医疗保健行业的广泛应用中使用这些模块化分子克隆的模块化分子克隆和方法，例如在治疗，临床诊断，体内成像或药物发现中。 本发明的模块化分子克隆还具有工业和环境应用，例如在环境诊断，工业诊断，食品安全，毒理学，反应催化或高通量筛选中。 以及农业行业的应用和基础研究。 还提供了设计模块化分子克隆的方法，以及包含这些模块分子克隆的阵列和生物传感器。

    IN VIVO ALTERATION OF CELLULAR DNA
    17.
    发明申请
    IN VIVO ALTERATION OF CELLULAR DNA 审中-公开
    细胞DNA的体内变异

    公开(公告)号：US20070243616A1

    公开(公告)日：2007-10-18

    申请号：US11749489

    申请日：2007-05-16

    申请人： George Church ,  Nikos Reppas

    发明人： George Church ,  Nikos Reppas

    IPC分类号： C12N15/87 ,  C12N15/00

    CPC分类号： C12N15/90 ,  A01K2217/05 ,  A01K2217/075 ,  C12N15/902

    摘要： The present invention relates to methods, cells and compositions for performing in vivo recombination without the need for clonal selection. These methods, cells and compositions are useful for the automation of recombination. The present invention provides methods for performing sequential steps in genome engineering, as well as for achieving parallel and multiplex genome engineering.

    摘要翻译： 本发明涉及用于进行体内重组而不需要克隆选择的方法，细胞和组合物。 这些方法，细胞和组合物可用于重组的自动化。 本发明提供了用于在基因组工程中执行顺序步骤以及实现并行和多重基因组工程的方法。

    Labeling compositions and methods of use for deterrent trackability
    18.
    发明申请
    Labeling compositions and methods of use for deterrent trackability 审中-公开
    用于威慑可追踪性的标记组合物和使用方法

    公开(公告)号：US20070172429A1

    公开(公告)日：2007-07-26

    申请号：US11464361

    申请日：2006-08-14

    申请人： Xiaolian Gao ,  David Bear ,  George Church ,  Xiaochuan Zhou

    发明人： Xiaolian Gao ,  David Bear ,  George Church ,  Xiaochuan Zhou

    IPC分类号： A61K9/44 ,  C12Q1/68 ,  G01N33/551

    CPC分类号： G01N33/58 ,  G06Q10/08

    摘要： Compositions and methods for controlling and tracking items are provided. More particularly, labeling compositions useful as a coding system to deter diversion of items of medication or other valued items are provided, wherein the labeling compositions comprise at least 25 unique identifiers, wherein the at least 25 unique identifiers are selected from a set of at least 50 unique identifiers. Also provided are methods for using such compositions to provide trackability throughout a chain of custody.

    摘要翻译： 提供了用于控制和跟踪项目的组合和方法。 更具体地，提供了可用作编码系统的标记组合物，以阻止药物或其他重要物品的转移，其中所述标记组合物包含至少25个唯一标识符，其中所述至少25个唯一标识符选自至少一组 50个唯一标识符。 还提供了使用这种组合物以提供整个保管链的追踪性的方法。

    Accessible polynucleotide libraries and methods of use thereof
    19.
    发明申请
    Accessible polynucleotide libraries and methods of use thereof 审中-公开
    可接近的多核苷酸文库及其使用方法

    公开(公告)号：US20060281113A1

    公开(公告)日：2006-12-14

    申请号：US11436478

    申请日：2006-05-17

    申请人： George Church ,  Edmund Pitcher

    发明人： George Church ,  Edmund Pitcher

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34

    CPC分类号： C12N15/66 ,  C12N15/10 ,  C12N15/1093

    摘要： Disclosed are methods of assembling nucleic acid constructs from component parts in a manner that is not dependent on the sequence of the component parts. The methods may be used to assemble large nucleic acid constructs from multiple component parts in one or more reactions. The methods may also be used to assemble two or more nucleic acid constructs in the same reaction mixture. In exemplary embodiments, the methods involve formation of a Holliday junction or bridge structure using a junction oligonucleotide.

    摘要翻译： 公开了以不依赖于组分部分序列的方式从组分部分组装核酸构建体的方法。 该方法可用于在一个或多个反应中从多个组分部分组装大的核酸构建体。 该方法还可用于在相同的反应混合物中组装两个或多个核酸构建体。 在示例性实施方案中，所述方法包括使用连接寡核苷酸形成Holliday结或桥结构。

    Targeted polypeptide degradation
    20.
    发明申请
    Targeted polypeptide degradation 有权
    靶向多肽降解

    公开(公告)号：US20050152888A1

    公开(公告)日：2005-07-14

    申请号：US11003103

    申请日：2004-12-03

    申请人： George Church ,  Daniel Janse

    发明人： George Church ,  Daniel Janse

    IPC分类号： A61K38/48 ,  C12N9/64 ,  C12N15/62

    CPC分类号： C12N15/62 ,  C07K2319/20 ,  C07K2319/95 ,  G01N2500/02

    摘要： This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

    摘要翻译： 本发明涉及可用于将多肽选择性定位于蛋白酶体降解的组合物，方法，细胞和生物体。 提供了通过靶向这些用于降解的多肽来治疗与多肽的表达和/或活性相关的病症的治疗方法和药物组合物，以及用于通过降解降解和/或激活治疗性多肽的治疗性多肽的方法。 本发明提供鉴定介导蛋白酶体定位和/或多肽降解的化合物的方法。 本发明还提供了研究蛋白质功能的研究工具。