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32 条记录 (耗时 0.109 秒)

    Methods and compositions for multiplex PCR
    14.
    发明授权
    Methods and compositions for multiplex PCR 有权
    多重PCR的方法和组成

    公开(公告)号：US08728736B2

    公开(公告)日：2014-05-20

    申请号：US13619178

    申请日：2012-09-14

    申请人： John Leamon ,  Mark Andersen ,  Michael Thornton

    发明人： John Leamon ,  Mark Andersen ,  Michael Thornton

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/686 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6874 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q2521/307 ,  C12Q2525/101 ,  C12Q2525/191 ,  C12Q2537/143

    摘要： The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants.

    摘要翻译： 本发明提供可用于样品中存在的一种或多种核酸的多重PCR的方法，组合物，试剂盒，系统和装置。 特别地，提供允许一个或多个靶序列的选择性扩增的各种靶特异性引物。 一方面，本发明涉及可用于选择性扩增与癌症或遗传性疾病相关的一种或多种靶序列的靶特异性引物。 在一些方面，使用所公开的方法，试剂盒，系统和装置获得的扩增靶序列可用于包括核酸测序在内的各种下游过程，并用于检测遗传变体的存在。

    Recessed sealed lighting fixture
    16.
    发明授权
    Recessed sealed lighting fixture 有权
    嵌入式密封照明灯具

    公开(公告)号：US08246196B2

    公开(公告)日：2012-08-21

    申请号：US13104707

    申请日：2011-05-10

    申请人： Casey Chung ,  Jill Cody ,  Brandon Stolte ,  Marcelino Pena ,  Michael Thornton

    发明人： Casey Chung ,  Jill Cody ,  Brandon Stolte ,  Marcelino Pena ,  Michael Thornton

    IPC分类号： F21S4/00 ,  F21S8/00 ,  F21V1/00 ,  F21V5/00 ,  F21V7/00 ,  F21V21/00

    CPC分类号： F21V17/164 ,  F21S8/02 ,  F21V3/04 ,  F21V5/02 ,  F21V15/015 ,  F21V17/14 ,  F21W2131/20 ,  F21Y2103/00 ,  F21Y2113/00 ,  Y10T29/49826

    摘要： In an embodiment, a recessed light fixture includes a structural reflector and two end caps that form a light fixture housing. A first, second and third optics areas are provided. At least one first light source type is mounted near the first optics area. A second light source type is mounted near the second optics area and the second light source type is mounted near the third optics areas, the second light source type having a light output level substantially lower than the light output level of the first light source type. A diffuser is configured to sealably mount to the light fixture housing so as to substantially seal an interior portion of the light fixture. In operation, the light fixture can be switch between an ambient mode and an examination mode while providing a cost effective and attractive design.

    摘要翻译： 在一个实施例中，嵌入式灯具包括结构反射器和形成灯具壳体的两个端盖。 提供第一，第二和第三光学区域。 至少一个第一光源类型安装在第一光学区域附近。 第二光源类型安装在第二光学区域附近，第二光源类型安装在第三光学区域附近，第二光源类型的光输出电平基本上低于第一光源类型的光输出电平。 扩散器被配置为可密封地安装到灯具壳体，以便基本上密封灯具的内部部分。 在操作中，灯具可以在环境模式和检查模式之间切换，同时提供成本有效和有吸引力的设计。

    System and method for guidingly mounting a power module to a processor
    17.
    发明申请
    System and method for guidingly mounting a power module to a processor 有权
    将功率模块引导到处理器的系统和方法

    公开(公告)号：US20050037658A1

    公开(公告)日：2005-02-17

    申请号：US10639276

    申请日：2003-08-12

    申请人： David Mayer ,  Michael Thornton

    发明人： David Mayer ,  Michael Thornton

    IPC分类号： G06F1/18 ,  H05K7/14 ,  H01R13/64

    CPC分类号： G06F1/185 ,  G06F1/184 ,  G06F1/186 ,  G06F1/188 ,  H01R12/7005 ,  H01R12/721 ,  H05K7/1431

    摘要： A system having a power module mount adapted to support a power module side-by-side with a card-based processor, and a connectivity guide adapted to guide the power module along a direct path between electrically connected and disconnected relationships with the card-based processor. A method for mounting a power module to a processor involving engaging the power module with a connectivity guide disposed adjacent the processor, moving the power module toward the processor via the connectivity guide, and mating edge connectors of the power module and the processor.

    摘要翻译： 一种具有功率模块安装座的系统，其适于与基于卡的处理器并排地支撑功率模块，以及连接引导件，适于沿着与基于卡的处理器的电连接和断开的关系之间的直接路径引导功率模块 处理器。 一种用于将功率模块安装到处理器的方法，所述方法包括使所述功率模块与邻近所述处理器设置的连接引导件接合，通过所述连接引导件将所述功率模块朝向所述处理器以及所述功率模块和所述处理器的配合边缘连接器移动。

    METHOD AND SYSTEM FOR ESTIMATING THE SPECIFIC ABSORPTION RATE OF A TISSUE REGION PRIOR TO A MAGNETIC RESONANCE IMAGING SCAN
    19.
    发明申请
    METHOD AND SYSTEM FOR ESTIMATING THE SPECIFIC ABSORPTION RATE OF A TISSUE REGION PRIOR TO A MAGNETIC RESONANCE IMAGING SCAN 审中-公开
    用于估计磁共振成像扫描前的组织区域的特定吸收率的方法和系统

    公开(公告)号：US20150316626A1

    公开(公告)日：2015-11-05

    申请号：US14704369

    申请日：2015-05-05

    申请人： Michael Thornton ,  Paul Picot ,  Brian Rutt ,  Simone Winkler

    发明人： Michael Thornton ,  Paul Picot ,  Brian Rutt ,  Simone Winkler

    IPC分类号： G01R33/28 ,  G01R33/58 ,  G01R33/54 ,  A61B5/055

    CPC分类号： A61B5/055 ,  A61B5/7225 ,  G01R33/288 ,  G01R33/54 ,  G01R33/58

    摘要： A method and system for estimating a specific; absorption rate of a tissue region prior to performing a magnetic resonance (MR) imaging scan on the tissue region. The method comprises radiating the tissue region with a plurality of short pulses, wherein the tissue region emits thermoacoustic signals responsive to the short pulses, receiving the thermoacoustic signals by at least one ultrasonic transducer, calculating a temperature rise of the tissue region based on the received thermoacoustic signals, scaling the temperature rise to estimate a temperature rise of the tissue region resulting from an MR imaging scan, and estimating the specific absorption rate of the tissue region based on the estimated temperature rise.

    摘要翻译： 用于估计特定的方法和系统; 在对组织区域进行磁共振（MR）成像扫描之前的组织区域的吸收率。 该方法包括用多个短脉冲辐射组织区域，其中组织区域响应于短脉冲发射热声信号，由至少一个超声波换能器接收热声信号，基于接收到的计算组织区域的温度升高 热声信号，缩放温度上升以估计由MR成像扫描产生的组织区域的温度升高，并且基于估计的温度升高来估计组织区域的比吸收率。

    Recessed Sealed Lighting Fixture
    20.
    发明申请
    Recessed Sealed Lighting Fixture 有权
    嵌入式密封照明灯具

    公开(公告)号：US20110211343A1

    公开(公告)日：2011-09-01

    申请号：US13104707

    申请日：2011-05-10

    申请人： Casey Chung ,  Jill Cody ,  Brandon Stolte ,  Marcelino Pena ,  Michael Thornton

    发明人： Casey Chung ,  Jill Cody ,  Brandon Stolte ,  Marcelino Pena ,  Michael Thornton

    IPC分类号： F21S4/00 ,  F21V15/01 ,  F21V11/00 ,  B23P17/04

    CPC分类号： F21V17/164 ,  F21S8/02 ,  F21V3/04 ,  F21V5/02 ,  F21V15/015 ,  F21V17/14 ,  F21W2131/20 ,  F21Y2103/00 ,  F21Y2113/00 ,  Y10T29/49826

    摘要： In an embodiment, a recessed light fixture includes a structural reflector and two end caps that form a light fixture housing. A first, second and third optics areas are provided. At least one first light source type is mounted near the first optics area. A second light source type is mounted near the second optics area and the second light source type is mounted near the third optics areas, the second light source type having a light output level substantially lower than the light output level of the first light source type. A diffuser is configured to sealably mount to the light fixture housing so as to substantially seal an interior portion of the light fixture. In operation, the light fixture can be switch between an ambient mode and an examination mode while providing a cost effective and attractive design.

    摘要翻译： 在一个实施例中，嵌入式灯具包括结构反射器和形成灯具壳体的两个端盖。 提供第一，第二和第三光学区域。 至少一个第一光源类型安装在第一光学区域附近。 第二光源类型安装在第二光学区域附近，第二光源类型安装在第三光学区域附近，第二光源类型的光输出电平基本上低于第一光源类型的光输出电平。 扩散器被配置为可密封地安装到灯具壳体，以便基本上密封灯具的内部部分。 在操作中，灯具可以在环境模式和检查模式之间切换，同时提供成本有效和有吸引力的设计。