公开(公告)号：US08937048B2

公开(公告)日：2015-01-20

申请号：US13595250

申请日：2012-08-27

Applicant: Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

Inventor： Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

IPC: A61K38/10 ,  C07K14/00 ,  C07K14/515 ,  A61K47/48 ,  C07K14/71

CPC classification number: A61K47/48215 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48507 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6835 ,  C07K14/71

Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.

Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管发生相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。

公开(公告)号：US08865873B2

公开(公告)日：2014-10-21

申请号：US12724282

申请日：2010-03-15

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C07K16/30 ,  A61K51/10 ,  C07K16/28

CPC classification number: C07K16/3069 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/77 ,  G01N33/5044 ,  G01N33/57434 ,  G01N33/6845 ,  G01N33/6854

Abstract: This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.

Abstract translation: 本发明提供允许使用激光捕获显微切割原位选择针对细胞（例如肿瘤细胞）的抗体的方法。 通过将抗体选择限于内化表位的结合物，产生一组靶向临床表现的前列腺癌抗原的噬菌体抗体。

公开(公告)号：US08688715B1

公开(公告)日：2014-04-01

申请号：US13491092

申请日：2012-06-07

Applicant: Trystan G. Upstill ,  Abhishek Das ,  Srinivasan Venkatachary ,  Shravya R. Shetty ,  Bin Liu ,  Jack W. Menzel

Inventor： Trystan G. Upstill ,  Abhishek Das ,  Srinivasan Venkatachary ,  Shravya R. Shetty ,  Bin Liu ,  Jack W. Menzel

IPC: G06F17/30

CPC classification number: G06F17/3053 ,  G06F17/30554 ,  G06F17/30864 ,  G06F17/30867

Abstract: A method includes receiving a query that that is unstructured for a plurality databases; receiving data identifying resources that are determined to be responsive to the query, each resource associated with a search score that defines a respective position of the resource in an order of responsiveness to the query; determining, a service requirement from the terms of the query; determining, for each of the databases, a service requirement score for the database; for each resource that is associated with one of the databases, adjusting the search score based on the service requirement score for the database; generating search results, each search result identify a corresponding resource that was determined to be responsive to the query, and the search results being ordered according to the respective search scores and adjusted search scores of the resources.

Abstract translation: 一种方法包括接收对于多个数据库是非结构化的查询; 接收识别被确定为响应于所述查询的资源的数据，每个资源与搜索分数相关联，所述搜索分数以响应于所述查询的顺序定义所述资源的相应位置; 确定来自查询条款的服务要求; 为每个数据库确定数据库的服务需求分数; 对于与其中一个数据库相关联的每个资源，根据数据库的服务需求分数调整搜索分数; 生成搜索结果，每个搜索结果标识被确定为响应于该查询的对应资源，并且根据相应的搜索分数和资源的调整的搜索分数对搜索结果进行排序。

公开(公告)号：US08669055B2

公开(公告)日：2014-03-11

申请号：US12903176

申请日：2010-10-12

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C12Q1/68 ,  C12M1/34 ,  C07H19/00 ,  C07H21/04 ,  C07H21/02 ,  G01N21/64

CPC classification number: C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

Abstract: The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及共轭聚合物，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US08597634B2

公开(公告)日：2013-12-03

申请号：US12676511

申请日：2007-09-04

Applicant: Weidong Zhou ,  Qingjiang Xiao ,  Li Sun ,  Tiebing Wang ,  Bin Liu ,  Song Lin ,  Min Liu ,  Fenghong Yin ,  Lu Zhuang ,  Lifang Lei

Inventor： Weidong Zhou ,  Qingjiang Xiao ,  Li Sun ,  Tiebing Wang ,  Bin Liu ,  Song Lin ,  Min Liu ,  Fenghong Yin ,  Lu Zhuang ,  Lifang Lei

IPC: A61K38/21 ,  A61K38/00 ,  A61K39/385 ,  C07K14/56

CPC classification number: C07K14/56 ,  A61K38/00 ,  A61K47/60 ,  Y02A50/473

Abstract: The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.

Abstract translation: 本发明涉及在具有Y型支链聚乙二醇（PEG）衍生物的特定Lys残基修饰的干扰素（IFN）-α2a及其制备方法，以及使用经单PEG修饰的IFN-α2a 药物中的氨基酸残基。

公开(公告)号：US08420407B2

公开(公告)日：2013-04-16

申请号：US12772508

申请日：2010-05-03

Applicant: Rong Zhang ,  Zili Xie ,  Bin Liu ,  Xiangqian Xiu ,  Henan Fang ,  Hong Zhao ,  Xuemei Hua ,  Ping Han ,  Peng Chen ,  Youdou Zheng

Inventor： Rong Zhang ,  Zili Xie ,  Bin Liu ,  Xiangqian Xiu ,  Henan Fang ,  Hong Zhao ,  Xuemei Hua ,  Ping Han ,  Peng Chen ,  Youdou Zheng

IPC: H01L21/00 ,  H01L21/469 ,  H01L21/8246

CPC classification number: C23C16/0272 ,  C23C16/34 ,  C30B25/02 ,  C30B29/38 ,  H01L21/0242 ,  H01L21/02458 ,  H01L21/02502 ,  H01L21/0262

Abstract: A kind of growth method of Fe3Nin the MOCVD system, comprising following process: 1) make the surface nitridation of sapphire substrate; 2) pump in carrier gas N2, ammonia and organic gallium sources, and grow low temperature GaN buffer on substrate; 3) raise temperature and grow the GaN supporting layer; 4) pump in FeCp2 as Fe sources, then grow Fe3N on the GaN supporting layer; the Fe3N granular films and the Fe3N single crystal films are obtained.

Abstract translation: MOCVD系统中Fe3N的一种生长方法，包括以下过程：1）使蓝宝石衬底的表面氮化; 2）在载气N2，氨和有机镓源中泵送，并在衬底上生长低温GaN缓冲液; 3）升高温度并生长GaN支撑层; 4）将FeCp2泵作为Fe源，然后在GaN支撑层上生长Fe3N; 得到Fe 3 N粒状膜和Fe 3 N单晶膜。

公开(公告)号：US08296710B2

公开(公告)日：2012-10-23

申请号：US12845204

申请日：2010-07-28

Applicant: Bin Liu ,  Zhiru Zhang ,  Jason Cong

Inventor： Bin Liu ,  Zhiru Zhang ,  Jason Cong

IPC: G06F17/50

CPC classification number: G06F17/505

Abstract: A method for implementing soft constraints in scheduling comprises receiving a description of circuit behavior. The description is un-timed. A scheduling solution is generated for use in scheduling the description. The scheduling solution includes scheduling variables and an objective function. The scheduling variables schedule the time of at least one operation. The objective function includes a penalty term and constraints comprising at least one hard constraint and at least one soft constraint. The constraints are created on the scheduling variables. The penalty term comprises a slack variable representing violations of the constraints. The penalty term measures the design cost of violating the soft constraint. Following generation of the scheduling solution, the description is scheduled by applying the scheduling solution to the description. Timing information of the description is provided as an output of the scheduling.

Abstract translation: 用于在调度中实现软约束的方法包括接收电路行为的描述。 描述是不及时的。 生成调度解决方案用于调度描述。 调度解决方案包括调度变量和目标函数。 调度变量调度至少一个操作的时间。 目标函数包括惩罚项和包含至少一个硬约束和至少一个软约束的约束。 在调度变量上创建约束。 惩罚项包括表示违反约束的松弛变量。 罚款条款衡量违反软约束的设计成本。 在生成调度解决方案之后，通过将调度解决方案应用于描述来调度描述。 提供描述的定时信息作为调度的输出。

公开(公告)号：US20110206334A1

公开(公告)日：2011-08-25

申请号：US12597995

申请日：2008-04-28

Applicant: Xin Liu ,  Binqiang Zeng ,  Bin Liu ,  Xiaozhou Guo

Inventor： Xin Liu ,  Binqiang Zeng ,  Bin Liu ,  Xiaozhou Guo

IPC: G02B6/44

CPC classification number: G02B6/4454

Abstract: The invention relates to an optical fibre splicing module. The optical fibre splicing module includes a base and a cover board, with two operation planes being arranged on the base, i.e. an upper operation plane provided with an optical fibre cable core winding area, a bare fibre winding and fusion welding area and an adapter holder, and a lower operation plane provided with a fibre pigtail winding area. 16 or 32 bayonets are arranged on the adapter holder, the bayonets are longitudinally arranged along the vertical direction of the operation planes. The size of the bayonets is just suitably connected to the vertically placed adapters. Not only the number of bayonets is increased to a number meeting the requirements of the optical splitter, but also the volume of the entire optical fibre splicing module can be ensured not to be increased by using the arrangement of the bayonets and the matching method of the bayonets with the vertically arranged adapters. Also, the integrity degree can be improved and the requirements of the optical splitter can be met, without changing the shape and size of existing adapters.

Abstract translation: 本发明涉及一种光纤拼接模块。 光纤拼接模块包括基座和盖板，底座上设有两个操作平面，即设置有光缆芯线圈区域的上操作平面，裸光纤绕组和熔焊区域以及适配器支架 以及设置有纤维尾纤卷绕区域的下部操作面。 16或32个卡口布置在适配器支架上，卡口沿操作平面的垂直方向纵向布置。 刺刀的尺寸只适合连接到垂直放置的适配器。 不仅将卡口的数量增加到满足分光器要求的数量，还可以通过使用卡口的布置和匹配方法来确保整个光纤拼接模块的体积不增加 卡口与垂直安装的适配器。 此外，可以在不改变现有适配器的形状和尺寸的情况下，提高完整性程度并满足光分路器的要求。

公开(公告)号：US20110169593A1

公开(公告)日：2011-07-14

申请号：US12685132

申请日：2010-01-11

Applicant: Juhai Hu ,  Yulin Zhang ,  Bin Liu ,  Jianning Jiang

Inventor： Juhai Hu ,  Yulin Zhang ,  Bin Liu ,  Jianning Jiang

IPC: H01H9/00

CPC classification number: H01H71/322 ,  H01H71/123 ,  H01H83/02

Abstract: A pulse activated magnetic trip/reset mechanism for a ground fault circuit interrupter, comprising: (i) a body, (ii) a ferrite core, (iii) a plunger, (iv) a ferrite surrounding, (v) a permanent magnet, (vi) a trip/reset coil, (vii) a reset spring positioned between a plunger block and the body, (viii) a first fixed contact holder having a first fixed contact point, and (ix) a first movable contact holder having a first movable contact point, wherein the first movable contact holder is attached to the body of the plunger such that when the plunger is in its first position (trip position), the first movable contact point is not in contact with the first fixed contact point, and when the plunger is in its second position (reset position), the first movable contact point is in contact with the first fixed contact point.

Abstract translation: 一种用于接地故障电路断续器的脉冲激励磁跳闸/复位机构，包括：（i）主体，（ii）铁氧体磁芯，（iii）柱塞，（iv）围绕（v）永磁体的铁氧体， （vi）跳闸/复位线圈，（vii）定位在柱塞块和主体之间的复位弹簧，（viii）具有第一固定接触点的第一固定触点保持器，和（ix）第一可动触点保持器， 第一可动接触点，其中第一可动触头保持器附接到柱塞的主体，使得当柱塞处于其第一位置（跳闸位置）时，第一可动触点不与第一固定触点接触， 并且当柱塞处于其第二位置（复位位置）时，第一可动触点与第一固定触点接触。

公开(公告)号：US20110136358A1

公开(公告)日：2011-06-09

申请号：US12949251

申请日：2010-11-18

Applicant: Yulin Zhang ,  Bin Liu ,  Jianning Jiang

Inventor： Yulin Zhang ,  Bin Liu ,  Jianning Jiang

IPC: H01R13/44

CPC classification number: H01R13/4534 ,  H01R24/76 ,  H01R2103/00

Abstract: A symmetrically movable safety structure disposed inside of an upper lid of a power panel, includes a cover plate disposed with a jack corresponding to the upper lid, a first shielding part and a second shielding part, disposed within the cover plate, where a first bonding position and a second bonding position corresponding to the jack are formed at a contacting place of the above two shielding parts, and a first elastic part and a second elastic part, wherein the first elastic part is disposed between the cover plate and the first shielding part, the second elastic part is disposed between the cover plate and the second shielding part, and the first shielding part and the second shielding part contact with each other under elastic force application directions.

Abstract translation: 设置在电源面板的上盖的内部的对称运动的安全结构包括设置有与上盖相对应的插孔的盖板，设置在盖板内的第一屏蔽部分和第二屏蔽部分，其中第一接合 在上述两个屏蔽部分的接触位置处形成与插座相对应的位置和第二接合位置，以及第一弹性部分和第二弹性部分，其中第一弹性部分设置在盖板和第一屏蔽部分之间 所述第二弹性部配置在所述盖板与所述第二遮蔽部之间，所述第一遮蔽部和所述第二遮蔽部在弹力施加方向上相互接触。