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    Device and method for detecting redox reactions in solution
    11.
    发明授权
    Device and method for detecting redox reactions in solution 有权
    用于检测溶液中氧化还原反应的装置和方法

    公开(公告)号：US09222908B2

    公开(公告)日：2015-12-29

    申请号：US13839564

    申请日：2013-03-15

    Applicant: Intel Corporation

    Inventor： Jonathan S. Daniels ,  Oguz H. Elibol ,  Grace M. Credo ,  Xing Su

    IPC: G01N27/30 ,  B82Y30/00 ,  G01N27/327

    CPC classification number: G01N27/30 ,  B82Y30/00 ,  G01N27/3277 ,  Y10S977/734 ,  Y10S977/742

    Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.

    Abstract translation: 本文描述的是一种装置，包括：多个以阵列排列的第一反应电极，多个第一反应电极构造成暴露于流体并具有电容; 第一电路，被配置为可控地将所述多个第一反应电极设置为预定电压，并允许所述多个第一反应电极的电容通过所述流体进行充电或放电; 以及第二电路，被配置为测量所述多个第一反应电极的电容的充电或放电速率。 本文还描述了使用该装置来对DNA进行序列化的方法。

    Massively parallel integrated circuit-based DNA synthesis devices, systems, and methods
    12.
    发明授权
    Massively parallel integrated circuit-based DNA synthesis devices, systems, and methods 有权

    公开(公告)号：US10704088B2

    公开(公告)日：2020-07-07

    申请号：US15929030

    申请日：2018-06-29

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Grace Credo

    IPC: C12Q1/6844 ,  B01J19/00 ,  B01L3/00 ,  C07H21/04

    Abstract: DNA synthesis devices, systems, and methods are disclosed. An apparatus can include a synthesizer chip having an array of reaction units in a predetermined pattern, each reaction unit including a reaction surface and a reaction electrode of an IC array of reaction electrodes, and a synthesizer chip controller coupled to the IC array of reaction electrodes configured to address each reaction electrode individually. The apparatus can also include a reagent delivery chip positionable above the synthesizer chip, comprising an array of reagent delivery units arranged in the predetermined pattern, each reagent delivery unit including a reagent electrode of an IC array of reagent electrodes and each reagent delivery unit configured to receive and deliver a droplet of reagent fluid having a volume of 1 picoliter or less, and a reagent delivery chip controller coupled to the IC array of reagent electrodes configured to address each reagent electrode individually.

    Metal oxide gas sensor array devices, systems, and associated methods
    13.
    发明授权
    Metal oxide gas sensor array devices, systems, and associated methods 有权

    公开(公告)号：US10330624B2

    公开(公告)日：2019-06-25

    申请号：US15201437

    申请日：2016-07-02

    Applicant: Intel Corporation

    Inventor： Noureddine Tayebi ,  Xing Su

    IPC: G01N27/12 ,  G01N33/00

    Abstract: Methods, systems, and devices for detecting an analyte are disclosed and described. In one embodiment, a Metal Oxide Semiconductor (MOS) sensor pixel with a MOS active material is exposed to the analyte in the gas environment. The MOS sensor pixel is heated to a sequence of different predetermined temperatures via a heating element wherein the heating occurs for a period of time for each of the different predetermined temperatures. Response signals are detected, via an electrode, generated by the MOS sensor at each of the different predetermined temperatures. The response signals are assembled into sample data with data features for machine learning. The sample data is compared with data in a standards database. A composition of the analyte is identified based on the data features.

    METAL OXIDE GAS SENSOR ARRAY DEVICES, SYSTEMS, AND ASSOCIATED METHODS
    14.
    发明申请
    METAL OXIDE GAS SENSOR ARRAY DEVICES, SYSTEMS, AND ASSOCIATED METHODS 审中-公开

    公开(公告)号：US20180003660A1

    公开(公告)日：2018-01-04

    申请号：US15201437

    申请日：2016-07-02

    Applicant: Intel Corporation

    Inventor： Noureddine Tayebi ,  Xing Su

    IPC: G01N27/12

    CPC classification number: G01N27/124 ,  G01N27/123 ,  G01N27/125 ,  G01N33/0006 ,  G01N33/0047

    Abstract: Methods, systems, and devices for detecting an analyte are disclosed and described. In one embodiment, a Metal Oxide Semiconductor (MOS) sensor pixel with a MOS active material is exposed to the analyte in the gas environment. The MOS sensor pixel is heated to a sequence of different predetermined temperatures via a heating element wherein the heating occurs for a period of time for each of the different predetermined temperatures. Response signals are detected, via an electrode, generated by the MOS sensor at each of the different predetermined temperatures. The response signals are assembled into sample data with data features for machine learning. The sample data is compared with data in a standards database. A composition of the analyte is identified based on the data features.

    Integrated photonic electronic sensor arrays for nucleic acid sequencing
    15.
    发明授权
    Integrated photonic electronic sensor arrays for nucleic acid sequencing 有权
    用于核酸测序的集成光子电子传感器阵列

    公开(公告)号：US09593371B2

    公开(公告)日：2017-03-14

    申请号：US14142603

    申请日：2013-12-27

    Applicant: INTEL CORPORATION

    Inventor： Xing Su ,  Mark Oldham

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  G01N27/00 ,  C12Q2521/101 ,  C12Q2521/543 ,  C12Q2537/157 ,  C12Q2563/116 ,  C12Q2565/607

    Abstract: Devices and methods for detecting, identifying, and sequencing, compounds, complexes, and molecules are described. Electronic detection is combined with optical excitation to determine the presence or identity of an analyte of interest. Embodiments of the invention additionally provide devices and methods that allow highly parallel nucleic acid sequence determination.

    Abstract translation: 描述用于检测，鉴定和测序化合物，复合物和分子的装置和方法。 电子检测与光激发组合以确定感兴趣的分析物的存在或身份。 本发明的实施方案另外提供允许高度平行核酸序列测定的装置和方法。

    Integrated Photonics Based Sensor System
    16.
    发明申请
    Integrated Photonics Based Sensor System 审中-公开
    集成光子学传感器系统

    公开(公告)号：US20160282265A1

    公开(公告)日：2016-09-29

    申请号：US14669514

    申请日：2015-03-26

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Kadhair Al-Hemyari ,  Kai Wu ,  Grace M. Credo ,  Haisheng Rong ,  Jacob Sendowski

    IPC: G01N21/41

    CPC classification number: G01N21/7746 ,  G01N21/39 ,  G01N21/553 ,  G01N2021/773 ,  G01N2021/7776

    Abstract: An embodiment includes a sensor comprising a substrate die; a photonic ring resonator (RR) on the substrate die; a polymer, on the RR, having an affinity to a chemical analyte; a photonic waveguide on the substrate die and coupled to the RR; a laser, on the substrate die and coupled to the waveguide, to emit optical energy that operates with the RR at a resonance wavelength; and a photodetector, on the substrate die and coupled to the waveguide, to detect a change in refractive index (RI) of the RR operating with the optical energy in response to the polymer coupling to the analyte. Other embodiments are described herein.

    Abstract translation: 一个实施例包括一个包括一个基片的传感器; 在衬底裸片上的光子环谐振器（RR）; RR上的聚合物对化学分析物具有亲和性; 衬底上的光子波导管并耦合到RR; 激光器，在基板裸片上并且耦合到波导，以发射与RR在谐振波长下工作的光能; 以及光电检测器，其在所述基板裸片上并耦合到所述波导，以检测响应于与所述分析物的所述聚合物耦合而用所述光能操作的所述RR的折射率（RI）的变化。 本文描述了其它实施例。

    Data storage based on encoded DNA sequences
    17.
    发明授权
    Data storage based on encoded DNA sequences 有权

    公开(公告)号：US11093547B2

    公开(公告)日：2021-08-17

    申请号：US15929022

    申请日：2018-06-19

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Kai Wu ,  Noureddine Tayebi ,  Grace Credo

    IPC: H03M7/00 ,  G06F16/901 ,  H03M7/30 ,  G06F16/11 ,  G06F16/178 ,  G16B30/00 ,  G16B50/50

    Abstract: Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include an encoder engine configured to encode a data file having a bit sequence encoding data and further configured to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment comprising a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.

    DEVICE AND METHOD FOR PARTICLE COMPLEX HANDLING
    18.
    发明申请
    DEVICE AND METHOD FOR PARTICLE COMPLEX HANDLING 审中-公开

    公开(公告)号：US20200166440A1

    公开(公告)日：2020-05-28

    申请号：US16778536

    申请日：2020-01-31

    Applicant: Intel Corporation

    Inventor： Xing Su ,  David J. Liu ,  Kai Wu ,  Kenneth B. Swartz ,  Mineo Yamakawa

    IPC: G01N1/40 ,  G01N35/08 ,  B01L3/00

    Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

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