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    Biomarker detection using integrated purification-detection devices
    11.
    发明授权
    Biomarker detection using integrated purification-detection devices 有权

    公开(公告)号：US11033901B2

    公开(公告)日：2021-06-15

    申请号：US16168228

    申请日：2018-10-23

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Benjamin Wunsch ,  Stacey Gifford ,  Sung-Cheol Kim

    IPC: G06T7/00 ,  B01L3/00

    Abstract: Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.

    BONDED NANOFLUIDIC DEVICE CHIP STACKS
    12.
    发明申请
    BONDED NANOFLUIDIC DEVICE CHIP STACKS 审中-公开

    公开(公告)号：US20200312834A1

    公开(公告)日：2020-10-01

    申请号：US16364649

    申请日：2019-03-26

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

    Inventor： Benjamin Wunsch ,  Joshua T. Smith ,  Stacey Gifford ,  Michael Albert Pereira

    IPC: H01L25/00 ,  H01L23/00 ,  H01L25/065 ,  H01L25/04 ,  G01N33/50 ,  G01N33/487

    Abstract: A method of producing a bonded chip stack is described. A first nanofluidic device chip having a first through-wafer via is formed. A second nanofluidic device chip having a second through-wafer via is formed. The first nanofluidic device chip and the second nanofluidic device chip are washed with a detergent solution. A first surface of the first nanofluidic device chip and a second surface of the second nanofluidic device chip are activated by treating the first surface and the second surface with an activation solution. The first nanofluidic device chip and the second nanofluidic device chip are arranged in a stack. The first through-wafer via is aligned with the second through-wafer via in a substantially straight line. The stack of first and second nanofluidic device chips is subjected to annealing conditions.

    PRECISION FABRICATION OF NANOSIEVES
    13.
    发明申请
    PRECISION FABRICATION OF NANOSIEVES 审中-公开

    公开(公告)号：US20200262698A1

    公开(公告)日：2020-08-20

    申请号：US16276342

    申请日：2019-02-14

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Stacey Gifford ,  Sung-Cheol Kim ,  Benjamin Wunsch

    IPC: B81C1/00 ,  B01D29/44 ,  B01D29/00 ,  B01L3/00

    Abstract: An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.

    MICROFLUIDIC DEVICES WITH MULTIPLE INLETS AND OUTLETS
    15.
    发明公开
    MICROFLUIDIC DEVICES WITH MULTIPLE INLETS AND OUTLETS 审中-公开

    公开(公告)号：US20240042437A1

    公开(公告)日：2024-02-08

    申请号：US18488331

    申请日：2023-10-17

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Benjamin Wunsch ,  Stacey Gifford

    IPC: B01L3/00

    CPC classification number: B01L3/502746 ,  B01L3/502761 ,  G01N15/1056

    Abstract: Techniques regarding nanofluidic chips with a plurality of inlets and/or outlets in fluid communication with one or more nanoDLD arrays are provided. For example, one or more embodiments described herein can comprise a nanoscale deterministic lateral displacement array between and in fluid communication with a global inlet and a global outlet. The nanoscale deterministic lateral displacement array can further be between and in fluid communication with a local inlet and a local outlet. Also, the nanoscale deterministic lateral displacement array can laterally displace a particle comprised within a sample fluid supplied from the global inlet to a collection region that directs the particle to the local outlet. An advantage of such an apparatus can be the expanded versatility of the nanoscale deterministic lateral displacement array for sample preparation applications involving nanoparticles not accessible to other higher throughput microscale microfluidic technologies.

    Microfluidic devices with multiple inlets and outlets
    16.
    发明授权
    Microfluidic devices with multiple inlets and outlets 有权

    公开(公告)号：US11833511B2

    公开(公告)日：2023-12-05

    申请号：US17135609

    申请日：2020-12-28

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Benjamin Wunsch ,  Stacey Gifford

    IPC: B01L3/00 ,  G01N15/10 ,  B82B3/00 ,  G01N15/02

    CPC classification number: B01L3/502746 ,  B01L3/502761 ,  B01L2300/0896 ,  B82B3/0014 ,  G01N15/1056 ,  G01N2015/0288 ,  G01N2015/1081

    Abstract: Techniques regarding nanofluidic chips with a plurality of inlets and/or outlets in fluid communication with one or more nanoDLD arrays are provided. For example, one or more embodiments described herein can comprise a nanoscale deterministic lateral displacement array between and in fluid communication with a global inlet and a global outlet. The nanoscale deterministic lateral displacement array can further be between and in fluid communication with a local inlet and a local outlet. Also, the nanoscale deterministic lateral displacement array can laterally displace a particle comprised within a sample fluid supplied from the global inlet to a collection region that directs the particle to the local outlet. An advantage of such an apparatus can be the expanded versatility of the nanoscale deterministic lateral displacement array for sample preparation applications involving nanoparticles not accessible to other higher throughput microscale microfluidic technologies.

    MICROFLUIDIC CHIPS WITH ONE OR MORE VIAS FILLED WITH SACRIFICIAL PLUGS
    17.
    发明申请
    MICROFLUIDIC CHIPS WITH ONE OR MORE VIAS FILLED WITH SACRIFICIAL PLUGS 有权

    公开(公告)号：US20220347681A1

    公开(公告)日：2022-11-03

    申请号：US17813429

    申请日：2022-07-19

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Robert Bruce ,  Jyotica V. Patel ,  Benjamin Wunsch

    IPC: B01L3/00

    Abstract: Techniques regarding microfluidic chips with one or more vias filled with sacrificial plugs and/or manufacturing methods thereof are provided herein. For example, one or more embodiments described herein can comprise an apparatus, which can comprise a silicon device layer of a microfluidic chip comprising a plurality of vias extending through the silicon device layer. The plurality of vias comprise greater than or equal to about 100 vias per square centimeter of a surface of the silicon device layer and less than or equal to about 100,000 vias per square centimeter of the surface of the silicon device layer. Additionally, the apparatus can comprise a plurality of sacrificial plugs positioned in the plurality of vias.

    MICROFLUIDIC DEVICES WITH MULTIPLE INLETS AND OUTLETS
    19.
    发明申请
    MICROFLUIDIC DEVICES WITH MULTIPLE INLETS AND OUTLETS 有权

    公开(公告)号：US20210114027A1

    公开(公告)日：2021-04-22

    申请号：US17135609

    申请日：2020-12-28

    Applicant: International Business Machines Corporation

    Inventor： Joshua T. Smith ,  Benjamin Wunsch ,  Stacey Gifford

    IPC: B01L3/00

    Abstract: Techniques regarding nanofluidic chips with a plurality of inlets and/or outlets in fluid communication with one or more nanoDLD arrays are provided. For example, one or more embodiments described herein can comprise a nanoscale deterministic lateral displacement array between and in fluid communication with a global inlet and a global outlet. The nanoscale deterministic lateral displacement array can further be between and in fluid communication with a local inlet and a local outlet. Also, the nanoscale deterministic lateral displacement array can laterally displace a particle comprised within a sample fluid supplied from the global inlet to a collection region that directs the particle to the local outlet. An advantage of such an apparatus can be the expanded versatility of the nanoscale deterministic lateral displacement array for sample preparation applications involving nanoparticles not accessible to other higher throughput microscale microfluidic technologies.

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