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公开(公告)号：US20210180114A1
公开(公告)日：2021-06-17
申请号：US17181228
申请日：2021-02-22
Applicant: INTEGENX, INC.
Inventor： David Eberhart , William D. Nielsen , Helen Franklin , Stevan B. Jovanovich , Dennis Lehto , Kaiwan Chear , James Klevenberg , Chungsoo Charles Park , Corey M. Smith , Philip Justus Wunderle , David King
IPC: C12Q1/6806 , B01L3/00 , C12Q1/686 , G01N27/447
Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.
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公开(公告)号：US10525467B2
公开(公告)日：2020-01-07
申请号：US15342914
申请日：2016-11-03
Applicant: IntegenX Inc.
Inventor： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar EL-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
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公开(公告)号：US10210410B2
公开(公告)日：2019-02-19
申请号：US14919741
申请日：2015-10-22
Applicant: IntegenX Inc.
Inventor： Robert A. Schueren , David King , Chungsoo Charles Park , Stevan B. Jovanovich
Abstract: A biometric biochemical analysis system includes a user interface module to provide instructions for collecting and handling biochemical sampling and processing related to biometric data gathering as well as capturing biometric data using digital data capturing devices. The user interface module and display are integrated with analysis and communications portions of the biometric biochemical analysis system to provide a portable system for multi-portion data collecting, storage, verification, and analysis.
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公开(公告)号：US10191071B2
公开(公告)日：2019-01-29
申请号：US15037039
申请日：2014-11-17
Applicant: IntegenX Inc.
Inventor： James Ogg , David Eberhart , William D. Nielsen , Helen Franklin , Stevan B. Jovanovich
IPC: G01N35/00 , B01L3/00 , B01L7/00 , C12Q1/6818 , C12Q1/686 , C12Q1/6888
Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.
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公开(公告)号：US20180293680A1
公开(公告)日：2018-10-11
申请号：US15570730
申请日：2016-04-30
Applicant: IntegenX Inc.
Inventor： Robert A. Schueren , David King , Stevan B. Jovanovich
Abstract: Provided herein is a system and method for review of forensic report computer files. The method can involve notifying a plurality of service providers of a job to be performed, accepting a bid from a service provider to perform the job, providing the computer file to the service provider, receiving from the service provider a forensic result such as a reviewed file.
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Patent Agency Ranking
公开(公告)号：US20170002399A1
公开(公告)日：2017-01-05
申请号：US15117053
申请日：2015-04-30
Applicant: INTEGENX INC.
Inventor： David Eberhart , William D. Nielsen , Helen Franklin , Stevan B. Jovanovich , Dennis Lehto , Kaiwan Chear , David King , James Klevenberg , Chungsoo Charles Park , Corey Smith , Philip Justus Wunderle
IPC: C12Q1/68 , G01N27/447 , B01L3/00
CPC classification number: C12Q1/6806 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0681 , B01L2300/0848 , B01L2300/087 , B01L2300/123 , B01L2400/0406 , B01L2400/0478 , C12Q1/686 , G01N27/44743 , G01N27/44791 , C12Q1/6846 , C12Q2565/629
Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.
Abstract translation: 本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。 可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。 还提供了构造成接合盒的盒接口。 还提供了包括盒式接口和使用盒和系统的方法的系统。
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公开(公告)号：US08894946B2
公开(公告)日：2014-11-25
申请号：US13656503
申请日：2012-10-19
Applicant: IntegenX Inc.
Inventor： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar El-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
CPC classification number: C12Q1/68 , B01L3/502715 , B01L3/5029 , B01L3/527 , B01L7/52 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0616 , G01N27/44704 , G01N2035/00158
Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
Abstract translation: 本公开提供了一种综合和自动化的样本回答系统，其从包含生物材料的样品开始，在少于两小时内产生遗传图谱。 在某些实施方案中，生物材料是DNA，并且遗传图谱涉及确定受试者的一个或多个位点（例如，遗传基因座）等位基因，例如STR（短串联重复）分布，例如如 CODIS系统。 该系统可以执行多个操作，包括（a）提取和分离核酸; （b）在选择的位点（例如遗传基因座）扩增核苷酸序列; 和（c）扩增产物的检测和分析。 这些操作可以在包括多个集成模块的系统中进行，包括分析物准备模块; 检测和分析模块和控制模块。
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公开(公告)号：US20250069174A1
公开(公告)日：2025-02-27
申请号：US18943248
申请日：2024-11-11
Applicant: IntegenX Inc.
Inventor： Robert A. Schueren , David King , Stevan B. Jovanovich
IPC: G06Q50/26 , G06F16/11 , G06Q10/0631 , G06Q30/0601 , G06Q50/00 , G06Q50/18 , G16B50/00 , H04W4/12 , H04W36/30 , H04W56/00 , H04W72/21 , H04W76/19 , H04W76/27
Abstract: Provided herein is a system and method for review of forensic report computer files. The can include a logic processor with a memory or storage configured with logic instructions to provide or facilitate: a data-accessing module for reading and reviewing an original forensic biological data file; an evaluation module for determining whether the original forensic biological data file meets quality criteria for uploading to a forensic matching or identification service or database; and a crowd-sourcing expert review module for communicating with one or more experts for review of the data file when quality criteria or not met and receiving notifications and results from the one or more experts.
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公开(公告)号：US11151674B2
公开(公告)日：2021-10-19
申请号：US15570730
申请日：2016-04-30
Applicant: IntegenX Inc.
Inventor： Robert A. Schueren , David King , Stevan B. Jovanovich
IPC: G01N33/48 , G01N33/50 , G06Q50/26 , G06F16/11 , G06Q50/00 , G06Q50/18 , G06Q10/06 , G06Q30/06 , H04W4/12
Abstract: Provided herein is a system and method for review of forensic report computer files. The method can involve notifying a plurality of service providers of a job to be performed, accepting a bid from a service provider to perform the job, providing the computer file to the service provider, receiving from the service provider a forensic result such as a reviewed file.
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公开(公告)号：US20190242917A1
公开(公告)日：2019-08-08
申请号：US16258412
申请日：2019-01-25
Applicant: IntegenX Inc.
Inventor： James Ogg , David Eberhart , William D. Nielsen , Helen Franklin , Stevan B. Jovanovich
IPC: G01N35/00 , C12Q1/6818 , B01L7/00 , B01L3/00 , C12Q1/6888 , C12Q1/686
CPC classification number: G01N35/00663 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/026 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/044 , B01L2300/0627 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B01L2300/18 , B01L2300/1827 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0644 , B01L2400/0655 , C12Q1/6818 , C12Q1/686 , C12Q1/6888 , G01N2035/00673
Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.
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