公开(公告)号：US07961312B2

公开(公告)日：2011-06-14

申请号：US12191096

申请日：2008-08-13

Applicant: Jan Lipson ,  Thomas J. Lenosky ,  Jeffrey M. Bernhardt

Inventor： Jan Lipson ,  Thomas J. Lenosky ,  Jeffrey M. Bernhardt

IPC: G01N3/00 ,  G01N3/44 ,  G01N33/53

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/441 ,  A61B5/4839 ,  A61B5/7232 ,  G01N21/65

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

公开(公告)号：US20110037977A1

公开(公告)日：2011-02-17

申请号：US12911489

申请日：2010-10-25

Applicant: Jan Lipson ,  Thomas J. Lenosky ,  Jeffrey M. Bernhardt

Inventor： Jan Lipson ,  Thomas J. Lenosky ,  Jeffrey M. Bernhardt

IPC: G01J3/44

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/441 ,  A61B5/4839 ,  A61B5/7232 ,  G01N21/65

Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

Abstract translation: 通过光谱测量可以确定复杂混合物中分析物的浓度，即使分析物以外的物质的光谱与分析物的光谱重叠。 使用训练集和分析物光谱中分析物的独立测量浓度。 归因于分析物的光谱数据的差异与其他原因的光谱变化隔离，例如与独立于分析物的不同样品相关的组成变化。 对于在生物体的皮肤上进行非侵入性葡萄糖测量的特殊情况，从血糖预测样品中的体积平均葡萄糖。 还描述了用于过拟合数据的测试。

公开(公告)号：US07560298B2

公开(公告)日：2009-07-14

申请号：US10850903

申请日：2004-05-21

Applicant: Jan Lipson

Inventor： Jan Lipson

IPC: H01L21/00

CPC classification number: G02B6/1225 ,  B82Y20/00 ,  H01S5/026 ,  H01S5/0607 ,  H01S5/105 ,  H01S5/183 ,  H01S5/18319

Abstract: Methods are disclosed for producing a tunable vertical cavity surface emitting laser (VCSEL) using photonic crystals and an electrostrictive material that includes a hologram with a narrow filter function. Photonic crystals are formed such that the active region of the VCSEL is bounded by the photonic crystals. The photonic crystals have a periodic cavity structure that reflects light of certain wavelengths through the active region of the VCSEL such that laser light at the wavelengths is generated. The periodic cavity structure includes a central defect that does not include any cavities. The single mode is emitted through the central defect. The electrostrictive material that includes a hologram makes the VCSEL tunable because the shape of the electrostrictive material changes when an electric field is applied. The filter function of the hologram thus changes as well in response to the electric field such that the VCSEL is tunable.

Abstract translation: 公开了用于使用光子晶体生产可调谐垂直腔表面发射激光器（VCSEL）的方法和包括具有窄滤波器功能的全息图的电致伸缩材料。 形成光子晶体，使得VCSEL的有源区域被光子晶体限制。 光子晶体具有通过VCSEL的有源区域反射某些波长的光的周期性空腔结构，使得产生波长的激光。 周期性空腔结构包括不包括任何空腔的中心缺陷。 单一模式通过中心缺陷发射。 包括全息图的电致伸缩材料使得VCSEL可调谐，因为当施加电场时电致伸缩材料的形状改变。 因此，全息图的滤波器功能也响应于电场而改变，使得VCSEL是可调谐的。

公开(公告)号：US07536213B2

公开(公告)日：2009-05-19

申请号：US11764123

申请日：2007-06-15

Applicant: Jan Lipson ,  Robert P. McNamara ,  Jeff Bernhardt

Inventor： Jan Lipson ,  Robert P. McNamara ,  Jeff Bernhardt

IPC: A61B5/1455 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/65 ,  A61B5/0059 ,  G01N21/645

Abstract: A method is proposed whereby photo-bleaching is used not only to change the absorption and fluorescence of a sample but is also employed to change its scattering characteristics. When the compounds which are bleached are contained in regions wherein the real part of the index of refraction is greater than or equal to the average index of the medium, the bleaching will result in reduction in the scattering at wavelengths longer than the wavelength of the bleaching source. This reduction can be useful in measuring the concentration of analytes located at significant depths within turbid media.

Abstract translation: 提出了一种方法，其中光漂白不仅用于改变样品的吸收和荧光，而且还用于改变其散射特性。 当漂白的化合物包含在折射率的实部大于或等于介质的平均指数的区域中时，漂白将导致波长比漂白波长长的波长的减少 资源。 这种减少可用于测量位于浑浊介质中显着深度的分析物的浓度。

公开(公告)号：US07266401B2

公开(公告)日：2007-09-04

申请号：US10923264

申请日：2004-08-20

Applicant: Jan Lipson

Inventor： Jan Lipson

IPC: A61B5/00 ,  G01J3/44 ,  G01J3/30 ,  G01J3/42

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/1838 ,  G01N21/274 ,  G01N21/31 ,  G03H1/0005

Abstract: Weak signals scattered from analytes at multiple wavelengths can be summed to illuminate either a single detector or a multiplicity of detectors, offering the possibility of concentrating the spectral energy on a smaller total detector area. In addition, a method is disclosed whereby a calibration of the resulting signal for a given analyte can be obtained by means of measuring the quantity of water in the sample volume and by means of measuring the salinity of the fluid in the sample volume.

Abstract translation: 可以将从多个波长的分析物散射的弱信号相加，以照亮单个检测器或多个检测器，从而提供将光谱能量集中在更小的总检测器面积上的可能性。 此外，公开了一种方法，通过测量样品体积中的水量并通过测量样品体积中的流体的盐度，可以获得对于给定分析物的所得信号的校准。

公开(公告)号：US07092418B2

公开(公告)日：2006-08-15

申请号：US11011807

申请日：2004-12-14

Applicant: James Stewart ,  Jan Lipson ,  Andreas Weber

Inventor： James Stewart ,  Jan Lipson ,  Andreas Weber

IPC: H01S3/04

CPC classification number: H01S5/02212 ,  H01L2224/48091 ,  H01L2924/3011 ,  H01S5/02415 ,  H01S5/183 ,  H01L2924/00014 ,  H01L2924/00

Abstract: This disclosure concerns optical packages such as may be used in optical transceivers and transmitters. In one example, an optical package includes a header assembly having a base portion to which is attached a header structure that is split into first and second portions that are separated from each other by a space. The header structure further includes one or more electrical leads extending through the base portion and into one of the first and second portions of the header structure. An active temperature control device is included in the optical package and resides in the space between the first and second portions of the header structure. Finally, an optical element, such as a laser, is provided that is arranged for thermal communication with the active temperature control device so that operation of the optical element can be controlled by way of the active temperature control device.

Abstract translation: 本公开涉及诸如可以用在光收发器和发射机中的光学封装。 在一个示例中，光学封装包括具有基部的插座组件，附接有头部结构，该头部结构被分割成彼此分开的空间的第一和第二部分。 插头结构还包括延伸穿过基座部分并且插入插头结构的第一和第二部分之一的一个或多个电引线。 主动温度控制装置包括在光学封装中并且位于头部结构的第一和第二部分之间的空间中。 最后，提供了诸如激光器的光学元件，其被布置成与主动温度控制装置进行热连通，使得可以通过主动温度控制装置来控制光学元件的操作。

公开(公告)号：US20060108340A1

公开(公告)日：2006-05-25

申请号：US11269974

申请日：2005-11-08

Applicant: Jan Lipson

Inventor： Jan Lipson

IPC: B23K26/067

CPC classification number: B23K26/22 ,  B23K26/0604

Abstract: A laser system that can be used to perform manufacturing process such as welding, cutting, drilling and marking a work piece. The laser system includes an array of laser diodes that each generate a laser beam. The laser beams may collectively create a beam that is directed onto the work piece. The system also includes a control circuit that can select and control the laser diodes to vary a characteristic(s) and/or profile of the beam. The control circuit may control the laser diodes so that an outer area of the beam has a higher intensity than an inner area of the beam.

Abstract translation: 可用于执行焊接，切割，钻孔和标记工件等制造工艺的激光系统。 激光系统包括激光二极管阵列，每个激光二极管都产生激光束。 激光束可以共同地产生被引导到工件上的光束。 该系统还包括可以选择和控制激光二极管以改变光束的特性和/或轮廓的控制电路。 控制电路可以控制激光二极管，使得光束的外部区域具有比光束的内部区域更高的强度。

公开(公告)号：US20050124870A1

公开(公告)日：2005-06-09

申请号：US10923264

申请日：2004-08-20

Applicant: Jan Lipson

Inventor： Jan Lipson

IPC: A61B5/00 ,  G01J3/30 ,  G01J3/42 ,  G01J3/427 ,  G01J3/44 ,  G01N20060101 ,  G01N21/27 ,  G01N21/31 ,  G01N33/487 ,  G03H1/00

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/1838 ,  G01N21/274 ,  G01N21/31 ,  G03H1/0005

Abstract: Weak signals scattered from analytes at multiple wavelengths can be summed to illuminate either a single detector or a multiplicity of detectors, offering the possibility of concentrating the spectral energy on a smaller total detector area. In addition, a method is disclosed whereby a calibration of the resulting signal for a given analyte can be obtained by means of measuring the quantity of water in the sample volume and by means of measuring the salinity of the fluid in the sample volume.

Abstract translation: 可以将从多个波长的分析物散射的弱信号相加，以照亮单个检测器或多个检测器，从而提供将光谱能量集中在更小的总检测器面积上的可能性。 此外，公开了一种方法，通过测量样品体积中的水量并通过测量样品体积中的流体的盐度，可以获得对于给定分析物的所得信号的校准。

公开(公告)号：US20050116239A1

公开(公告)日：2005-06-02

申请号：US11030412

申请日：2005-01-06

Applicant: Paul Rosenberg ,  Daniel Case ,  Jan Lipson ,  Rudolf Hofmeister ,  The' Nguyen

Inventor： Paul Rosenberg ,  Daniel Case ,  Jan Lipson ,  Rudolf Hofmeister ,  The' Nguyen

IPC: G02B6/42 ,  H05K1/02 ,  H05K1/18 ,  H05K3/34 ,  H01L29/267

CPC classification number: G02B6/4201 ,  H01L24/45 ,  H01L2224/05554 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/49111 ,  H01L2224/49175 ,  H01L2924/01013 ,  H01L2924/01028 ,  H01L2924/01079 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/30107 ,  H01L2924/3011 ,  H05K1/0243 ,  H05K1/189 ,  H05K3/3447 ,  H05K2201/0715 ,  H05K2201/10121 ,  H05K2201/10166 ,  H05K2201/10371 ,  H05K2203/1147 ,  H01L2924/00014 ,  H01L2924/00

Abstract: This disclosure concerns systems and devices configured to implement impedance matching schemes in a high speed data transmission environment. In one example, an optoelectronic assembly is provided that includes a TO package having a base through which one or more leads pass. The leads are electrically coupled to an optoelectronic device in the TO package, and are electrically isolated from the base. Some or all of the leads include a ground ring that is electrically isolated from the lead and electrically coupled with the base. A circuit interconnect is also included that is electrically coupled to the optoelectronic device and the TO package. The circuit interconnect includes a dielectric substrate having signal traces that are electrically coupled to the signal leads. A ground signal conductor disposed on the dielectric substrate is electrically coupled with the ground rings.

Abstract translation: 该公开涉及被配置为在高速数据传输环境中实现阻抗匹配方案的系统和设备。 在一个示例中，提供了一种光电组件，其包括具有一个或多个引线通过的基极的TO封装。 引线电耦合到TO封装中的光电子器件，并且与基极电隔离。 一些或全部引线包括与引线电隔离并与基极电耦合的接地环。 还包括电耦合到光电器件和TO封装的电路互连。 电路互连包括具有电耦合到信号引线的信号迹线的电介质基片。 设置在电介质基板上的接地信号导体与接地环电耦合。

公开(公告)号：US06829281B2

公开(公告)日：2004-12-07

申请号：US10175309

申请日：2002-06-19

Applicant: Hongyu Deng ,  Thomas Lenosky ,  Jan Lipson

Inventor： Hongyu Deng ,  Thomas Lenosky ,  Jan Lipson

IPC: H01S308

CPC classification number: H01S5/183 ,  H01S5/105

Abstract: A vertical cavity surface emitting laser (VCSEL) using photonic crystals. Photonic crystals are formed such that the active region of the VCSEL is bounded by the photonic crystals. The photonic crystals have a periodic cavity structure that reflects light of certain wavelengths through the active region of the VCSEL such that laser light at the wavelengths is generated. Additional photonic crystals can be formed to increase the bandwidth of the VCSEL. The photonic crystals can also be combined with distributed bragg reflector layers to form the mirrors of a VCSEL.

Abstract translation: 使用光子晶体的垂直腔表面发射激光器（VCSEL）。 形成光子晶体，使得VCSEL的有源区域被光子晶体限制。 光子晶体具有通过VCSEL的有源区域反射某些波长的光的周期性空腔结构，使得产生波长的激光。 可以形成额外的光子晶体以增加VCSEL的带宽。 光子晶体还可以与分布式布拉格反射器层组合以形成VCSEL的反射镜。