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    RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
    11.
    发明申请
    RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
    RAF抑制剂化合物及其使用方法

    公开(公告)号：US20120157451A1

    公开(公告)日：2012-06-21

    申请号：US13393069

    申请日：2010-08-27

    申请人： Stefan Gradl ,  Joachim Rudolph ,  Li Ren

    发明人： Stefan Gradl ,  Joachim Rudolph ,  Li Ren

    IPC分类号： A61K31/519 ,  A61P13/12 ,  A61P35/00 ,  C07D487/04 ,  A61K31/5377

    CPC分类号： C07D487/04

    摘要： Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

    摘要翻译： 式（I）的化合物可用于抑制Raf激酶。 公开了使用式（I）的化合物及其立体异构体，互变异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

    Process for mixing and proportioning several mixing components
    16.
    发明授权
    Process for mixing and proportioning several mixing components 失效
    用于混合和配比几种混合组分的方法

    公开(公告)号：US4498783A

    公开(公告)日：1985-02-12

    申请号：US421968

    申请日：1982-09-23

    申请人： Joachim Rudolph

    发明人： Joachim Rudolph

    IPC分类号： B01F7/30 ,  B01F3/18 ,  B01F13/10 ,  B01F15/02 ,  B01F15/04 ,  G05D11/04 ,  G05D11/13

    CPC分类号： B01F15/0445 ,  G05D11/134 ,  B01F2013/1052 ,  B01F2015/0221 ,  B01F3/18

    摘要： In a process for mixing and proportioning a plurality of mixing components, the latter are supplied in individually weighed manner to a continuous mixing process and the mixture is subsequently continuously removed in a proportioned manner. For this purpose, a mixer, metering feed means positioned upstream of the mixer and a continuously proportioning removal device positioned downstream of the mixer are provided. In order to ensure a troublefree addition and an accurately proportioned removal, the individual mixing components are in each case successively supplied in timed continuous manner to the mixing process, accompanied by the weighing of the total mixing material. During the feed pauses, the mixture is gravimetrically controlled and during addition is removed in volumetrically controlled manner. For this purpose the mixer, together with the removal device, is arranged on a weighing machine and the feed means and removal device are controlled by the weighing machine by means of a regulating and control device.

    摘要翻译： 在混合和配混多个混合组分的方法中，将后者以单独称量的方式供应至连续混合过程，随后以比例的方式连续除去混合物。 为此，提供一种混合器，位于混合器上游的计量给料装置和位于混合器下游的连续配比的去除装置。 为了确保无故障添加和精确比例的去除，各个混合组分在每种情况下以连续的方式连续地供应到混合过程中，伴随着总混合材料的称重。 在进料暂停期间，重量分析控制混合物，并以体积控制方式除去添加物。 为此，混合器与移除装置一起布置在称重机上，进料装置和去除装置由称重机通过调节和控制装置控制。