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公开(公告)号：US20070160539A1
公开(公告)日：2007-07-12
申请号：US11627831
申请日：2007-01-26
申请人： Lori Friedman , Gregory Plowman , Tak Hung , Helen Francis-Lang , Danxi Li , Roel Funke , Michael Costa
发明人： Lori Friedman , Gregory Plowman , Tak Hung , Helen Francis-Lang , Danxi Li , Roel Funke , Michael Costa
IPC分类号： A61K49/00 , C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
摘要翻译： 人hPRP4基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节hPRP4活性的试剂。
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公开(公告)号：US20060252035A1
公开(公告)日：2006-11-09
申请号：US10486306
申请日：2002-08-02
申请人： Lori Friedman , Gregory Plowman , Michael Costa , Danxi Li , Roel Funke , Tak Hung
发明人： Lori Friedman , Gregory Plowman , Michael Costa , Danxi Li , Roel Funke , Tak Hung
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.
摘要翻译： 人SPHK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节SPHK活性的试剂。
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公开(公告)号：US20050112568A1
公开(公告)日：2005-05-26
申请号：US10480068
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human DGK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,comprising screening for agents that modulate the activity of DKG are provided.
摘要翻译： 人DGK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节DKG活性的试剂。
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公开(公告)号：US20070286852A1
公开(公告)日：2007-12-13
申请号：US10556636
申请日：2004-06-18
申请人： Marcia Belvin , Helen Francis-Lang , Lori Friedman , Gregory Plowman , Monique Nicoll , Timothy Heuer
发明人： Marcia Belvin , Helen Francis-Lang , Lori Friedman , Gregory Plowman , Monique Nicoll , Timothy Heuer
CPC分类号： G01N33/5011 , G01N2333/82
摘要： Human SPPL genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPPL are provided.
摘要翻译： 人SPPL基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节SPPL活性的试剂。
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公开(公告)号：US20080102070A1
公开(公告)日：2008-05-01
申请号：US11852890
申请日：2007-09-10
CPC分类号： G01N33/5011 , C12Q1/485 , C12Q1/527 , G01N33/5017 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/90212 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.
摘要翻译： 人类SCD基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节SCD活性的药剂。
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16.发明申请公开(公告)号：US20060257870A1
公开(公告)日：2006-11-16
申请号：US10532405
申请日：2003-10-22
申请人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
发明人： Gregory Plowman , Felix Karim , Candace Swimmer , Hinrich Habeck , Thomas Koblizek , Stefan Schulte-Merker , Ulrike Langheinrich , Gordon Stott , Torsten Trowe , Andreas Vogel , Joerg Odenthal , Jochen Scheel , Torsten Will , Yisheng Jin , Bing Hai
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/57438 , C12Q1/485 , G01N33/57446 , G01N2500/00
摘要： Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided.
摘要翻译： 人CDKL1基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供用于鉴定分支形态发生调节剂的方法，包括筛选调节CDKL1活性的试剂。
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公开(公告)号：US07119174B2
公开(公告)日：2006-10-10
申请号：US10734126
申请日：2003-12-15
申请人： Gregory Plowman , James Bishoff
发明人： Gregory Plowman , James Bishoff
CPC分类号： C12Q1/485 , G01N2333/9121 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner.
摘要翻译： 本发明涉及AUR1和/或AUR2多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，此类多肽的抗体，利用此类多肽的测定法以及与上述所有相关的方法。 AUR1和/或AUR2相关疾病或特征为AUR1和/或AUR2多肽与AUR1和/或AUR2结合配偶体之间异常相互作用的病症的治疗，诊断和筛选方法。
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公开(公告)号：US20050084877A1
公开(公告)日：2005-04-21
申请号：US10838181
申请日：2004-05-04
申请人： Gregory Plowman , Ricardo Martinez , David Whyte , Gerard Manning , Sucha Sudarsanam , Ronald Hill , Peter Flanagan
发明人： Gregory Plowman , Ricardo Martinez , David Whyte , Gerard Manning , Sucha Sudarsanam , Ronald Hill , Peter Flanagan
CPC分类号： C07H21/04 , C07K16/40 , C12N9/16 , G01N2800/042
摘要： The present invention relates to phosphatase polypeptides having the amino acid sequence of SEQ ID NO:23 or SEQ ID NO:24, disclosed herein. The invention also relates to nucleotide sequences encoding the phosphatase polypeptides, vectors and recombinant cells comprising such sequences, antibodies having binding affinity to the phosphatase polypeptides, and other products. Included in the invention are methods for identifying modulators of the phosphatase polypeptides, as well as methods for diagnosing and treating various conditions related to the phosphatase polypeptides.
摘要翻译： 本发明涉及具有本文公开的SEQ ID NO：23或SEQ ID NO：24的氨基酸序列的磷酸酶多肽。 本发明还涉及编码磷酸酶多肽的核苷酸序列，载体和包含此类序列的重组细胞，对磷酸酶多肽具有结合亲和力的抗体，以及其它产物。 本发明包括用于鉴定磷酸酶多肽的调节剂的方法，以及用于诊断和治疗与磷酸酶多肽相关的各种病症的方法。
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公开(公告)号：US20050026184A1
公开(公告)日：2005-02-03
申请号：US10849244
申请日：2004-05-20
申请人： Gregory Plowman , Douglas Clary
发明人： Gregory Plowman , Douglas Clary
IPC分类号： C07K14/705 , C12N9/12 , C12N9/16 , C12Q1/68 , C07H21/04 , G01N33/574
CPC分类号： C12N9/1205 , C07K14/705 , C07K2319/00 , C12N9/16
摘要： The present invention relates to ALK-7 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for ALK-7 related diseases or conditions characterized by an abnormal interaction between an ALK-7 polypeptide and an ALK-7 binding partner.
摘要翻译： 本发明涉及ALK-7多肽，编码这种多肽的核酸，含有此类核酸的细胞，组织和动物，这种多肽的抗体，利用这些多肽的测定法，以及涉及上述所有方法的方法。 提供ALK-7相关疾病或ALK-7多肽与ALK-7结合配偶体异常相互作用特征的治疗，诊断和筛选方法。
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公开(公告)号：US5962312A
公开(公告)日：1999-10-05
申请号：US755728
申请日：1996-11-25
申请人： Gregory Plowman , Kevin Mossie
发明人： Gregory Plowman , Kevin Mossie
IPC分类号： G01N33/53 , A61K31/00 , A61K31/70 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N5/10 , C12N9/12 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/54 , C12P21/08 , C12Q1/68 , C12R1/91 , C12N15/63 , C07H21/04
CPC分类号： C07K16/40 , C12N9/12 , C12N9/1205 , A01K2217/05 , A61K48/00 , C12N2799/027
摘要： The present invention relates to AUR-1 and/or AUR-2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR-1 and/or AUR-2 related diseases or conditions characterized by an abnormal interaction between a AUR-1 and/or AUR-2 polypeptide and a AUR-1 and/or AUR-2 binding partner.
摘要翻译： 本发明涉及AUR-1和/或AUR-2多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，对这些多肽的抗体，利用此类多肽的测定法，以及与所有上述相关的方法 。 AUR-1和/或AUR-2相关疾病或AUR-1和/或AUR-2多肽与AUR-1和/或AUR之间的异常相互作用特征的AUR-1和/或AUR-2相关疾病或病症的治疗，诊断和筛选方法 -2绑定伙伴。
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