公开(公告)号：US08190266B2

公开(公告)日：2012-05-29

申请号：US11355094

申请日：2006-02-15

Applicant: Hossein Ameri ,  James Weiland ,  Helmut Eckhard ,  Stefan Ufer ,  Tanapat Ratanapakorn ,  Mark Humayun

Inventor： Hossein Ameri ,  James Weiland ,  Helmut Eckhard ,  Stefan Ufer ,  Tanapat Ratanapakorn ,  Mark Humayun

IPC: A61N1/00 ,  A61B5/04

CPC classification number: A61N1/36046 ,  A61N1/0543

Abstract: A wide-filed retinal prosthesis enables an increased field of vision with a relatively small scleral incision. The retinal prosthesis includes a flexible substrate comprising a central member and at least one wing, with an array of electrodes disposed therein that are configured to stimulate the central and peripheral nerves of the retina.

Abstract translation: 广泛的视网膜假体使得能够以相对小的巩膜切口增加视力。 视网膜假体包括柔性基底，其包括中心构件和至少一个翼，其中布置有电极阵列，其构造成刺激视网膜的中央和外周神经。

公开(公告)号：US20110279821A1

公开(公告)日：2011-11-17

申请号：US13106388

申请日：2011-05-12

Applicant: Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

Inventor： Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

IPC: G01B9/02

CPC classification number: G01B9/02028 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/04001 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/043 ,  A61B2562/063 ,  A61F2009/00851 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/3605 ,  G01B9/02007 ,  G01B9/02016 ,  G01B9/02027 ,  G01B9/02091 ,  G01N21/4795 ,  H04J14/02

Abstract: A multiplexed OCT imaging system includes a plurality of sample arms, an imaging engine, and an optical controller. The sample arms are optically coupled to the imaging engine via the optical controller; the optical controller multiplexes optical signals from the sample arms to permit some of the sample arms to operate sequentially or simultaneously.

Abstract translation: 复用的OCT成像系统包括多个样本臂，成像引擎和光学控制器。 样品臂通过光学控制器光学耦合到成像引擎; 光学控制器复用来自样品臂的光学信号，以允许一些样品臂顺序地或同时地操作。

公开(公告)号：US20110059146A1

公开(公告)日：2011-03-10

申请号：US12842593

申请日：2010-07-23

Applicant: Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

IPC: A01N25/34 ,  A01N33/12 ,  A01P1/00 ,  B05D3/10 ,  C08F10/06

CPC classification number: C09D5/14 ,  A01N33/12 ,  C08G73/0206 ,  C08G73/0226 ,  C09D5/1637 ,  C09D179/02 ,  D06M16/00 ,  Y10T428/31721 ,  Y10T428/31725 ,  A01N25/34 ,  A01N2300/00

Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.

Abstract translation: 本公开提供了适合于在基底上制备涂层的方法和材料。 涂层包含季胺基，因此赋予基底抗菌性能。 在一个实施方案中，例如，提供了包含丙烯和乙烯重复单元的含季铵的聚合物涂层。

公开(公告)号：US07794437B2

公开(公告)日：2010-09-14

申请号：US10543083

申请日：2004-01-26

Applicant: Mark Humayun ,  Eugene De Juan

Inventor： Mark Humayun ,  Eugene De Juan

IPC: A61M35/00

CPC classification number: A61F9/0017 ,  A61F2/16 ,  A61F2250/0068 ,  A61M5/1428 ,  A61M2210/0612

Abstract: Featured are devices and methods for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. Such instillation is accomplished by providing a reservoir containing a therapeutic medium to which is fluidly coupled a cannula and inserting a portion of the cannula sub-retinally, whereby the therapeutic medium within the reservoir is coupled to and dispersed subretinally via the cannula.

Abstract translation: 特别是用于将治疗性介质施用于眼后段的装置和方法，包括滴注或处置回顾性治疗介质。 这种滴注是通过提供一种包含治疗介质的储存器来实现的，该治疗介质流体地联接套管并且插入套管的一部分，其中储存器内的治疗介质通过套管联接到并且通过插管被分散地分散。

公开(公告)号：US20100228123A1

公开(公告)日：2010-09-09

申请号：US12718188

申请日：2010-03-05

Applicant: Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

Inventor： Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

IPC: A61B6/00 ,  B23P11/00 ,  A61B8/00 ,  A61N5/067 ,  A61B18/18 ,  A61B18/20

CPC classification number: A61B5/0066 ,  A61B3/10 ,  A61B3/102 ,  A61B3/14 ,  A61B5/0073 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/5276 ,  A61B18/20 ,  A61B34/20 ,  A61B2017/00207 ,  A61B2017/00694 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/061 ,  A61B2090/3735 ,  A61B2090/3954 ,  A61M25/01 ,  A61M2025/0166 ,  A61N5/00 ,  Y10T29/49826

Abstract: A device includes a handpiece having a probe tip disposed at an end thereof, and, connected to the handpiece such that, at the probe tip, a functionality of each is provided, a plurality of optical coherence tomography (OCT) probes.

Abstract translation: 一种装置包括具有设置在其端部的探针尖端的手持件，并且连接到所述手持件，使得在所述探针尖端处提供每个的功能，多个光学相干断层摄影（OCT）探针。

公开(公告)号：US20090306585A1

公开(公告)日：2009-12-10

申请号：US12463265

申请日：2009-05-08

Applicant: Changlin Pang ,  Jason Shih ,  Fukang Jiang ,  Sean Caffey ,  Mark Humayun ,  Yu-Chong Tai

Inventor： Changlin Pang ,  Jason Shih ,  Fukang Jiang ,  Sean Caffey ,  Mark Humayun ,  Yu-Chong Tai

IPC: A61M5/168 ,  A61M5/165

CPC classification number: A61M5/14276 ,  A61F9/00781 ,  A61M5/148 ,  A61M5/16804 ,  A61M5/16854 ,  A61M2005/14204 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2210/0612 ,  A61M2210/0693

Abstract: In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components.

Abstract translation: 在各种实施例中，可植入泵包括插管。 泵（例如其套管）可以包括例如流量传感器，压力传感器，过滤器和/或其它部件。

公开(公告)号：US20080039792A1

公开(公告)日：2008-02-14

申请号：US11686310

申请日：2007-03-14

Applicant: Ellis Meng ,  Yu-Chong Tai ,  Mark Humayun ,  Rajat Agrawal ,  Ronalee Lo ,  Jason Shih ,  Kenrick Kuwahara ,  Po-Ying Li ,  Damien Rodger ,  Po-Jui Chen

Inventor： Ellis Meng ,  Yu-Chong Tai ,  Mark Humayun ,  Rajat Agrawal ,  Ronalee Lo ,  Jason Shih ,  Kenrick Kuwahara ,  Po-Ying Li ,  Damien Rodger ,  Po-Jui Chen

IPC: A61M5/00

CPC classification number: A61F9/0017 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M5/14593 ,  A61M5/155 ,  A61M5/16877 ,  A61M5/16881 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/0244 ,  A61M2205/3507 ,  A61M2207/00 ,  A61M2210/0612 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/019 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0005 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0088 ,  Y10T29/49236

Abstract: An implantable device for delivering a therapeutic agent to a patient is provided. The device includes a reservoir configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.

Abstract translation: 提供了一种用于将治疗剂递送至患者的可植入装置。 该装置包括构造成容纳包含治疗剂的液体的储存器。 该装置还包括与储存器流体连通的套管。 套管具有被配置成与患者流体连通的出口。 该装置还包括第一电极和第二电极，第一电极和第二电极中的至少一个是平面的。 该装置还包括与第一和第二电极电连通的材料。 施加在第一电极和第二电极之间的电压从材料产生气体，气体迫使液体从储存器流出到出口。

公开(公告)号：US20070112263A1

公开(公告)日：2007-05-17

申请号：US11594054

申请日：2006-11-06

Applicant: Wolfgang Fink ,  Eui-Hyeok Yang ,  Yoshi Hishinuma ,  Choonsup Lee ,  Thomas George ,  Mark Humayun

Inventor： Wolfgang Fink ,  Eui-Hyeok Yang ,  Yoshi Hishinuma ,  Choonsup Lee ,  Thomas George ,  Mark Humayun

IPC: A61B3/16

CPC classification number: A61B3/16

Abstract: An optically powered and optically data-transmitting wireless intraocular pressure sensor device for detecting excessive intraocular pressure above a predetermined threshold pressure, comprising a pressure switch that is sized and configured to be placed in an eye, wherein said pressure switch is activated when the intraocular pressure is higher than the predetermined threshold pressure. In one embodiment, the pressure sensor device is a micro electromechanical system.

Abstract translation: 一种用于检测高于预定阈值压力的过度眼内压的光学和光数据传输无线眼内压传感器装置，包括尺寸和构造为放置在眼睛中的压力开关，其中所述压力开关在眼压 高于预定阈值压力。 在一个实施例中，压力传感器装置是微机电系统。

公开(公告)号：US20070055089A1

公开(公告)日：2007-03-08

申请号：US11593683

申请日：2006-11-07

Applicant: Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

Inventor： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC: A61N5/00

CPC classification number: A61N5/1017

Abstract: A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

Abstract translation: 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20070049987A1

公开(公告)日：2007-03-01

申请号：US11521281

申请日：2006-09-13

Applicant: Robert Greenberg ,  Mark Humayun

Inventor： Robert Greenberg ,  Mark Humayun

IPC: A61N1/36

CPC classification number: A61N1/36046 ,  A61F9/08 ,  A61N1/0543 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133

Abstract: Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally. The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.

Abstract translation: 申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜的方法。 本发明是用于视网膜下刺激的改进的电极阵列。 诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。 在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。 这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。