公开(公告)号：US4602031A

公开(公告)日：1986-07-22

申请号：US741935

申请日：1985-06-06

申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： An antidepressive imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基 ，卤素或 - - （其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二 低级烷基，低级烷氧基或三氟甲基，苯基氨基或苯基氨基，具有卤素，低级烷基，低级烷氧基或三氟甲基）; 及其药学上可接受的酸加成盐。

公开(公告)号：US4468394A

公开(公告)日：1984-08-28

申请号：US363778

申请日：1982-03-31

申请人： Yoshimasa Machida ,  Isao Saito ,  Isao Sugiyama ,  Shigeto Negi ,  Seiichiro Nomoto ,  Hironori Ikuta ,  Hiroshi Yamauchi ,  Kyosuke Kitoh

发明人： Yoshimasa Machida ,  Isao Saito ,  Isao Sugiyama ,  Shigeto Negi ,  Seiichiro Nomoto ,  Hironori Ikuta ,  Hiroshi Yamauchi ,  Kyosuke Kitoh

IPC分类号： C07D215/54 ,  C07D215/56 ,  C07D311/16 ,  C07D335/06 ,  C07D499/00 ,  C07D499/68 ,  C07D501/24 ,  A61K31/545 ,  C07D501/04 ,  C07D501/46 ,  C07D501/56

CPC分类号： C07D335/06 ,  C07D215/54 ,  C07D215/56 ,  C07D311/16 ,  C07D499/00

摘要： A compound represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or hydroxy; R is ##STR2## wherein R.sub.3 and R.sub.4 are hydroxy or acyloxy, Y is oxygen, sulfur or >N-R.sub.5 wherein R.sub.5 is hydrogen or lower alkyl, and Z is sulfur or >N-R.sub.5 wherein R.sub.5 has the same meanings as defined above; and X is ##STR3## wherein R.sub.6 is acyloxy or nitrogen-containing heterocyclicthio which may have substituent(s), a pharmaceutically accpetable salt thereof, and a carboxylic ester thereof.This compound has improved antibacterial activity against Kleb. pneumoniae and Pseud. aeruginosa.

摘要翻译： 由下式表示的化合物：其中R1是氢或甲氧基; R2是氢或羟基; R为其中R3和R4为羟基或酰氧基，Y为氧，硫或> N-R5，其中R5为氢或低级烷基，Z为硫或> N-R5，其中R5具有与上述相同的含义 ; X为，其中R6为可具有取代基的酰氧基或含氮杂环硫基，其药学上可接受的盐及其羧酸酯。 该化合物对Kleb具有改善的抗菌活性。 肺炎和Pseud。 铜绿假单胞菌

公开(公告)号：US4321631A

公开(公告)日：1982-03-23

申请号：US169265

申请日：1980-07-15

申请人： Isao Saito ,  Makoto Hirosawa ,  Seiya Sakamoto

发明人： Isao Saito ,  Makoto Hirosawa ,  Seiya Sakamoto

IPC分类号： H04N1/387 ,  G03F5/00 ,  H04N1/036 ,  H04N1/405 ,  H04N1/40

CPC分类号： H04N1/4055 ,  H04N1/036

摘要： In a method for reproducing a halftone picture by scanning, wherein a brightness and a width of a recording light beam to be projected on a photosensitive material is suitably controlled by means of picture signals obtained from the scanning of an original picture, a control method for reproducing a halftone dot cut away along a picture outline is disclosed, wherein a position of an outline in an original picture is detected, wherein the intersection of the outline with a halftone dot is discriminated by comparaing the two positions of the outline and the dot, and wherein a part of the dot positioned inside the outline is exposed by the recording light beam. This method is carried out by using a control device according to the present invention, which is also disclosed.

摘要翻译： 在通过扫描再现半色调图像的方法中，其中通过从原始图像的扫描获得的图像信号适当地控制要投影在感光材料上的记录光束的亮度和宽度，控制方法 公开了沿着图像轮廓切割的半色调点的再现，其中检测到原始图像中的轮廓的位置，其中通过比较轮廓和点的两个位置来区分轮廓与半色调点的交点， 并且其中位于轮廓内的点的一部分被记录光束曝光。 该方法通过使用本发明的控制装置进行，其也被公开。

公开(公告)号：US4285939A

公开(公告)日：1981-08-25

申请号：US137753

申请日：1980-04-07

申请人： Yoshimasa Machida ,  Isao Saito ,  Motosuke Yamanaka ,  Seiichiro Nomoto ,  Shigeto Negi ,  Kyosuke Kitoh ,  Kanemasa Katsu ,  Yukio Ohya ,  Takeshi Suzuki ,  Kyoko Koizumi

发明人： Yoshimasa Machida ,  Isao Saito ,  Motosuke Yamanaka ,  Seiichiro Nomoto ,  Shigeto Negi ,  Kyosuke Kitoh ,  Kanemasa Katsu ,  Yukio Ohya ,  Takeshi Suzuki ,  Kyoko Koizumi

IPC分类号： C07D501/22 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D311/22 ,  C07D501/34 ,  C07D501/20

CPC分类号： C07D311/22

摘要： New cephalosporin derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydroxy, acyloxy, and hydrogen provided that two or three of R.sub.1, R.sub.2, and R.sub.3 are not hydrogen at the same time, and their salts, and processes for the preparation thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

摘要翻译： 由以下通式表示的新型头孢菌素衍生物：其中R 1，R 2和R 3各自表示羟基，酰氧基和氢，条件是R 1，R 2和R 3中的两个或三个不同时为氢， ，及其制备方法。 本发明的头孢菌素衍生物可用作抗菌药物。

公开(公告)号：US07563886B2

公开(公告)日：2009-07-21

申请号：US10567364

申请日：2004-08-02

申请人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

发明人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

IPC分类号： C07H19/22

CPC分类号： C07H19/173 ,  C07H19/20 ,  C12Q1/6823 ,  C12Q2525/101

摘要： A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefore. A nucleoside of nucleotide (oligonucleotide containing thereof) represented by the formula (I) (wherein each of X and Y independently represents —O—, —NH—, —N(alkyl)- or —S—; R represents a functional unit, a reporter unit or a biofunctional molecule; each of R1 and R2 independently represents a hydrogen atom, a phosphate bond group, a phosphoramidite group or a nucleotide; and n is a numeral of 1 to 10). There is further provided a method of releasing the R group moiety at base portion by the use of the oligonucleotide comprising the nucleotide.

摘要翻译： 一种容易地释放与寡核苷酸结合而不损害目标核酸的有用物质的方法; 和一个新的基地。 由式（I）表示的核苷酸（其含有寡核苷酸）的核苷（其中X和Y各自独立地表示-O - ， - NH - ， - N（烷基） - 或-S-; R表示官能单元， 报告单元或生物功能分子; R 1和R 2各自独立地表示氢原子，磷酸键合基，亚磷酰胺基或核苷酸; n为1〜10的数）。 还提供了通过使用包含该核苷酸的寡核苷酸在碱基部分释放R基团部分的方法。

公开(公告)号：US07414117B2

公开(公告)日：2008-08-19

申请号：US10795436

申请日：2004-03-09

申请人： Isao Saito ,  Akimitsu Okamoto ,  Yoshio Saito ,  Yasuko Yoshida ,  Kousuke Niwa

发明人： Isao Saito ,  Akimitsu Okamoto ,  Yoshio Saito ,  Yasuko Yoshida ,  Kousuke Niwa

IPC分类号： C07H21/02 ,  C07H19/04 ,  C12Q1/68 ,  G01N33/53 ,  C07H21/00

CPC分类号： C07H19/04 ,  C07H19/06 ,  C07H19/067 ,  C07H19/16 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6837 ,  Y10S436/809 ,  C12Q2565/549

摘要： A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intendity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymin/uracil derivative (1) emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; a cytosine derivative (2) emitting light most intensely when the confronting base is guanine; an adenine derivative (3) emitting light most intensely when the confronting base is cytosine; a guanine derivative (4) emitting light most intensely when the confronting base is cytosine or thymine/uracil; and an adrnine derivative (5) emitting light most intensely when the confronting base is thymine/uracil/.

摘要翻译： 在存在单链序列成员的情况下，新的核苷酸衍生物依赖于与单链序列杂交的伴侣链中的相应碱基类型而经历荧光信号意图的变化，并且其是 当与单链核苷酸序列杂交的伴侣链中的相对的碱基是腺嘌呤时，最强烈地发射光的甲氨喋呤/尿嘧啶衍生物（1） 当相对的碱是鸟嘌呤时，胞嘧啶衍生物（2）最强地发射光; 当面对的碱基是胞嘧啶时，腺苷衍生物（3）最强地发光; 当面对的碱基是胞嘧啶或胸腺嘧啶/尿嘧啶时，最强烈地发射光的鸟嘌呤衍生物（4） 和当相对底物是胸腺嘧啶/尿嘧啶时最强烈地发光的腺苷衍生物（5）。

公开(公告)号：US07378237B2

公开(公告)日：2008-05-27

申请号：US10285030

申请日：2002-11-01

申请人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

发明人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

IPC分类号： C12Q1/68 ,  A61K49/00 ,  A61K31/70 ,  A61K39/395

CPC分类号： G01N33/5011

摘要： A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance containing DNA or RNA by using one or more chemical species represented by the following general formula (I) which are capable of recognizing a DNA base sequence; a kit therefor; and a plate to be used therein: B-L-A (I) wherein B represents a chemical structure containing an non-natural base capable of recognizing a DNA base sequence; A represents a chemical structure having an interaction with DNA; and L represents a linker whereby the chemical structures A and B can be linked together.

摘要翻译： 通过使用人造化学物质筛选片段A（化学物质A）对含有DNA或RNA的物质（例如细胞）的影响的方法。 即，通过使用能够识别DNA碱基序列的由以下通式（I）表示的一种或多种化学物质来检测或鉴定含有DNA或RNA的物质上的化学物质A的功能的方法; 一套工具; 和其中使用的板：B-L-A（I）其中B表示含有能够识别DNA碱基序列的非天然碱基的化学结构; A表示与DNA相互作用的化学结构; L表示连接物，化学结构A和B可以连接在一起。

公开(公告)号：US07351852B2

公开(公告)日：2008-04-01

申请号：US11111022

申请日：2005-04-21

申请人： Hisafumi Ikeda ,  Isao Saito ,  Yushin Nakamura

发明人： Hisafumi Ikeda ,  Isao Saito ,  Yushin Nakamura

IPC分类号： C07C261/00

CPC分类号： C07C255/60 ,  B01D15/362 ,  B01J39/04 ,  B01J39/26 ,  C07C235/38 ,  C07C269/06 ,  C07C271/20 ,  C07K1/062

摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.

摘要翻译： 由下列通式（I）表示的氨基酸衍生物的方法：（其中R 1表示氢原子或具有1-5个碳原子的直链或支链烷基），其具有 目的是提供式（I）的氨基酸衍生物及其合成中间体叔丁氧基羰基氨基 - 乙胺的方法，其不需要繁琐的程序，产率也良好，并且其在批量生产中的应用容易， 并提供式（IV）的新型氨基酸衍生物及其合成中间体及其方法，其特征在于，其包括通过水解所述通式（I）所示化合物的方法获得通式（I）所示的氨基酸衍生物的步骤 下式（II）：其中R 1具有与上述相同的含义，R 2表示具有1-4个碳原子的直链或支链烷基 原子）以及由通式（IV）表示的氨基酸衍生物：（其中R