公开(公告)号：US20090088616A1

公开(公告)日：2009-04-02

申请号：US11914701

申请日：2006-02-13

申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

公开(公告)号：US06907279B2

公开(公告)日：2005-06-14

申请号：US10452052

申请日：2003-06-03

申请人： Hiroki Sato ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/046

摘要： The invention provides optical technique for measuring metabolism in a living body that can further reduce an error in measurement even if distance between irradiation and detection is fixed. The living body is classified into measurement regions and different measuring wavelengths are set according to the classification. For example, the head is classified into four regions of a parietal region, a frontal region, a temporal region and an occipital region and a wavelength according to each tissue is set in a wavelength selecting system. In measurement, wavelengths according to each measurement region are selected by multiple wavelengths-light radiating means. Besides, for a region having large personal difference, premeasurement is made using plural combinations of wavelengths and wavelengths are selected using a calculated error in measurement as a criterion.

摘要翻译： 本发明提供了用于测量生物体内新陈代谢的光学技术，即使照射和检测之间的距离固定也能进一步降低测量误差。 将生物体分为测量区域，根据分类设置不同的测量波长。 例如，在波长选择系统中设置头部分为顶叶区域，正面区域，时间区域和枕骨区域的四个区域，并且根据每个组织设置波长。 在测量中，根据每个测量区域的波长由多个波长 - 光辐射装置选择。 此外，对于具有大的个人差异的区域，使用多个波长组合进行预测量，并且使用计算的测量误差作为标准来选择波长。

公开(公告)号：US07991447B2

公开(公告)日：2011-08-02

申请号：US10577944

申请日：2004-07-01

申请人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

发明人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/1455

CPC分类号： A61B5/14553

摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.

摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，将照射在试验体上的光的第1波长范围内的光与第2波长范围内的光的比例保持在规定值以下， 照射光强度的比例在预先指定的值之下。

公开(公告)号：US20100256468A1

公开(公告)日：2010-10-07

申请号：US12600285

申请日：2008-02-01

申请人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B5/1455 ,  G06N5/02

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/14553

摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

摘要翻译： 将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。 使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

公开(公告)号：US07613502B2

公开(公告)日：2009-11-03

申请号：US11205184

申请日：2005-08-17

申请人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

发明人： Yukari Yamamoto ,  Atsushi Maki ,  Masashi Kiguchi ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/064 ,  A61B5/6814 ,  A61B5/7425 ,  A61B5/743 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2063

摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

摘要翻译： 在探针定位技术中，光学生物仪器包括区域选择单元，其用于描绘对象的解剖图像中的感兴趣区域，计算单元，其根据感兴趣的区域确定推荐的探针位置，探针位置 检测当前探头位置的传感器，计算推荐探测位置与当前探测位置之间的距离的计算单元，以及当距离在预定范围内时产生报警声等的报警装置。 此外，生物体的光学生物仪器还包括存储单元，其中探测位置与测量数据一起被保存。

公开(公告)号：US20060006343A1

公开(公告)日：2006-01-12

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B8/06

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US09706955B2

公开(公告)日：2017-07-18

申请号：US14408644

申请日：2012-06-21

申请人： Hirokazu Atsumori ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Masashi Kiguchi

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G06N5/04 ,  A61B5/16

CPC分类号： A61B5/14553 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/165 ,  A61B5/486 ,  A61B5/7225 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7435 ,  A61B5/7475 ,  A61B2505/09 ,  A61B2560/0475 ,  A61B2562/0238 ,  G06N5/04

摘要： Provided is a biological state assessment device for assessing biological state, such as mood or emotions, using non-invasive biophotonic measurement technology. The present invention includes a light irradiation unit (1041), a light-receiving unit (1061), and an inputting means (112). A subject (800) is presented with a plurality of different problems (first problem, second problem), and a biological signal in the interior of the subject is calculated from the intensity of light received by the light-receiving unit (1061). Subjective information about the subject is accepted by the inputting means (112). The difference is calculated between the subjective information and the relative value of the biological signal of the measurement point for the first problem and the biological signal of the measurement point for the second problem, and the result is displayed.

公开(公告)号：US20070106139A1

公开(公告)日：2007-05-10

申请号：US11317002

申请日：2005-12-27

申请人： Koji Nagata ,  Hiroshi Mitsumaki ,  Tsuyoshi Uchida ,  Rinichi Asano ,  Masashi Kiguchi

发明人： Koji Nagata ,  Hiroshi Mitsumaki ,  Tsuyoshi Uchida ,  Rinichi Asano ,  Masashi Kiguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/01 ,  A61B5/14532 ,  A61B5/1491

摘要： Measurement of blood flow rate in a convenient manner has been enabled by using a simple device constitution and a simple signal processing technique. A measurement mechanism having both the function of measuring temperature of the measurement site and the function of applying a thermal load to the measurement site is used, and a process of extracting temperature change associated with the recovery of the surface temperature by the blood flow is conducted from the measurement results obtained by the measurement mechanism.

摘要翻译： 通过使用简单的装置结构和简单的信号处理技术，能够以便利的方式测量血液流量。 使用具有测量部位的温度的功能和对测量部位施加热负荷的功能的测量机构，并且进行与通过血流回收表面温度相关的温度变化的处理 从测量机构获得的测量结果。

公开(公告)号：US20140107439A1

公开(公告)日：2014-04-17

申请号：US14117154

申请日：2012-06-15

申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

IPC分类号： A61B5/16 ,  A61B5/1455

CPC分类号： A61B5/165 ,  A61B5/14551

摘要： Disclosed is a device using a biological optical measurement technology to evaluate mood states in daily life of an examinee by presenting a first task once or a plurality of times and then presents a second task a plurality of times, calculating a hemoglobin signal of a predetermined measurement point for the first task and a hemoglobin signal of a predetermined measurement point for the second task, and calculating quantitative values using the obtained hemoglobin signals.

摘要翻译： 公开了一种使用生物光学测量技术的装置，通过呈现第一任务一次或多次来评估受试者的日常生活中的情绪状态，然后多次呈现第二任务，计算预定测量的血红蛋白信号 指定第一任务和第二任务的预定测量点的血红蛋白信号，以及使用获得的血红蛋白信号计算定量值。

公开(公告)号：US20080259337A1

公开(公告)日：2008-10-23

申请号：US11944064

申请日：2007-11-21

申请人： Kazuhiko SAGARA ,  Yukio Kumagai ,  Naoki Matsushima ,  Masashi Kiguchi

发明人： Kazuhiko SAGARA ,  Yukio Kumagai ,  Naoki Matsushima ,  Masashi Kiguchi

IPC分类号： G01N21/00

CPC分类号： A61B5/0261 ,  A61B5/6814 ,  A61B2560/0252 ,  A61B2562/0233 ,  A61B2562/046

摘要： A cerebral function measuring apparatus houses a light detector in a package that can be set on the head of the subject examinee with light detection elements, amplifiers, and high voltage power supplies sealed in the package. Each amplifier and each high voltage power supply are united into one and covered with a high polymer material with high dielectric strength, and further enclosed by a metallic shield so as to be insulated. The high voltage power supply consists of a very small coil and an integrated circuit to generate a voltage required to drive the light detection element in the package. A removable and safe module type light detector is thus realized.

摘要翻译： 大脑功能测量装置容纳包装中的光检测器，该检测器可以被封装在被检体内的光检测元件，放大器和高压电源上。 每个放大器和每个高压电源组合成一个并覆盖有高介电强度的高聚合物材料，并进一步用金属屏蔽物封闭以便被绝缘。 高压电源由非常小的线圈和集成电路组成，以产生驱动封装中的光检测元件所需的电压。 从而实现了可移动和安全的模块型光检测器。