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    MAGNETIC SEPARATION USING NANOPARTICLES
    12.
    发明申请
    MAGNETIC SEPARATION USING NANOPARTICLES 审中-公开

    公开(公告)号：US20190336635A1

    公开(公告)日：2019-11-07

    申请号：US16511151

    申请日：2019-07-15

    Applicant: Children`s Medical Center Corporation ,  Massachusetts Institute of Technology

    Inventor： Jung-Jae Lee ,  Kyung Jae Jeong ,  Daniel S. Kohane

    IPC: A61L9/00 ,  A61L2/00

    Abstract: Nanoparticles as described herein are configured to bind to bacterial contaminants, such as Gram positive bacteria, Gram negative bacteria, and endotoxins. The nanoparticles include a core comprising a magnetic material; and a plurality of ligands attached to the core. The ligands include, for example, bis(dipicolylamine) (“DPA”) coordinated with a metal ion, e.g., Zn2+ or Cu2+, to form, e.g., bis-Zn-DPA or bis-Cu-DPA, which can bind to the bacterial contaminants. The nanoparticles can be included in compositions for use in methods and systems to separate bacterial contaminants from liquids, such as liquids, such as blood, e.g., whole or diluted blood, buffer solutions, albumin solutions, beverages for human and/or animal consumption, e.g., drinking water, liquid medications for humans and/or animals, or other liquids.

    SCAFFOLDS COMPRISING NANOELECTRONIC COMPONENTS FOR CELLS, TISSUES, AND OTHER APPLICATIONS
    13.
    发明申请
    SCAFFOLDS COMPRISING NANOELECTRONIC COMPONENTS FOR CELLS, TISSUES, AND OTHER APPLICATIONS 审中-公开
    包含电池组件，组织和其他应用的纳米电子元件

    公开(公告)号：US20170072109A1

    公开(公告)日：2017-03-16

    申请号：US15216068

    申请日：2016-07-21

    Applicant: President and Fellows of Harvard College ,  Massachusetts Institute of Technology ,  Children's Medical Center Corporation

    Inventor： Charles M. Lieber ,  Jia Liu ,  Bozhi Tian ,  Tal Dvir ,  Robert S. Langer ,  Daniel S. Kohane

    IPC: A61L27/56 ,  A61L27/18 ,  A61L27/02 ,  A61L27/38

    CPC classification number: A61L27/56 ,  A61L27/02 ,  A61L27/025 ,  A61L27/04 ,  A61L27/08 ,  A61L27/18 ,  A61L27/30 ,  A61L27/38 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/50 ,  A61L27/507 ,  A61L2400/12 ,  C12M25/14 ,  C12M35/02

    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.

    Abstract translation: 本发明一般涉及纳米线和组织工程。 在各种实施方案中，可以形成用于生长细胞或组织的细胞支架，其包括可连接到在细胞支架外部延伸的电子电路的纳米线。 纳米线可以形成从细胞支架生长的细胞或组织的组成部分，并且甚至可以被确定或控制，例如使用各种电子电路。 由于纳米线和电子电路提供的高度的电子控制，这种方法允许创建基本上新型的功能化细胞和组织。 因此，由于存在纳米线，这样的细胞支架可用于生长可以以非常高的分辨率确定和/或控制的细胞或组织，并且这种细胞支架可用于各种各样的新颖应用， 包括在组织工程，假肢，起搏器，植入物等中的应用。

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