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20 条记录 (耗时 0.019 秒)

    Liquid Detection and Confidence Determination
    13.
    发明申请
    Liquid Detection and Confidence Determination 审中-公开
    液体检测和置信度测定

    公开(公告)号：US20080138247A1

    公开(公告)日：2008-06-12

    申请号：US11719078

    申请日：2005-11-10

    申请人： Mats Inganas ,  Tobias Soderman ,  Erik Hogstrand

    发明人： Mats Inganas ,  Tobias Soderman ,  Erik Hogstrand

    IPC分类号： G01J3/00 ,  B01J19/00 ,  G01N35/00

    CPC分类号： G01N35/00069 ,  G01N35/08

    摘要： A method and a system for grading the confidence of a result of an experiment that comprises one or more biological and/or chemical reactions and is carried out in a microchannel structure (110a) of a microfluidic device, said confidence determination comprises the steps of: i) detecting within each of at least one liquid detector segment of said microchannel structure (110a) the presence or absence of liquid and/or gas during a period of time for which it is known if liquid and/or gas shall be present and/or absent in the segment, and ii) assigning a lowered confidence to said result if the presence and/or absence of liquid and/or gas found in step (i) is deviating from what it shall be.

    摘要翻译： 一种用于对包括一种或多种生物和/或化学反应的实验结果的置信度进行分级并在微流体装置的微通道结构（110a）中进行）的方法和系统，所述置信度确定包括以下步骤： ：i）在所述微通道结构（110a）的至少一个液体检测器段的每一个内检测液体和/或气体是否存在的一段时间内是否存在液体和/或气体 和/或在该段中不存在，以及ii）如果在步骤（i）中发现的液体和/或气体的存在和/或不存在偏离了它将是什么，则对所述结果分配降低的置信度。

    Flex Method
    14.
    发明申请
    Flex Method 审中-公开
    Flex方法

    公开(公告)号：US20070224702A1

    公开(公告)日：2007-09-27

    申请号：US11689702

    申请日：2007-03-22

    申请人： Mats Inganas ,  Mats Holmquist

    发明人： Mats Inganas ,  Mats Holmquist

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54386

    摘要： A method for quantifying n different analytes that are present in one or more liquid samples by performing n different affinity assay formats, each of which is dedicated for a particular one of the analytes. The characteristic feature is that each format is performed in a separate microchannel structures of a microfluidic device that contains at least n microchannel structures, and comprises formation and measurement of an immobilized product (affinity complex) that is formed on a solid phase that is placed in a microcavity of the microchannel structure used for the format in order to quantify the analyte to which the format is dedicated.

    摘要翻译： 一种通过执行n种不同亲和力测定形式来定量存在于一个或多个液体样品中的n种不同分析物的方法，其各自专用于特定的一种分析物。 特征在于，每种格式都在微流体装置的单独的微通道结构中进行，微流体装置包含至少n个微通道结构，并且包括形成和测量在固相上形成的固定化产物（亲和络合物） 用于格式的微通道结构的微腔，以量化格式所专用的分析物。

    Collection of micro scale devices
    15.
    发明申请
    Collection of micro scale devices 审中-公开
    收集微型装置

    公开(公告)号：US20060148065A1

    公开(公告)日：2006-07-06

    申请号：US10550182

    申请日：2004-03-23

    申请人： Mats Inganas

    发明人： Mats Inganas

    IPC分类号： C12M1/34

    CPC分类号： B01L3/5027 ,  B01L3/5025 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/069 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409

    摘要： A collection of one or more microfluidic devices which together carry a plurality of microchannel structures each of which comprises a reaction microcavity (104a-h) in which there is a solid phase with an immobilized affinity ligand L, characterized in that (i) the plurality is divided into sets of microchannel structures, and (ii) the affinity ligand L is directed to the same counterpart (binder, B) independent of set, and (iii) the sets differ in a) the capacity per reaction microcavity and/or the capacity/unit volume of the solid phase in a reaction microcavity for binder B, and/or b) the base matrix of the solid phase between the sets but are equal within each set.

    摘要翻译： 一个或多个微流体装置的集合，其一起携带多个微通道结构，每个微通道结构包括其中具有固定的亲和配体L的固相的反应微腔（104ah），其特征在于（i）多个是 分为几组微通道结构，和（ii）亲和配体L指向与组无关的相同对应物（粘合剂B），和（iii）组的不同之处在于a）每个反应的微腔容量和/或容量 /单位体积的固相在用于粘合剂B的反应微腔中的单位体积，和/或b）组之间的固相的基础矩阵，但在每组内相等。

    Method For Detecting An At Least Bivalent Analyte Using Two Affinity Reactants
    19.
    发明申请
    Method For Detecting An At Least Bivalent Analyte Using Two Affinity Reactants 审中-公开
    使用两种亲和反应物检测至少二价分析物的方法

    公开(公告)号：US20080233594A1

    公开(公告)日：2008-09-25

    申请号：US11815955

    申请日：2006-01-17

    申请人： Mats Inganas

    发明人： Mats Inganas

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： G01N35/00069 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2400/0409 ,  B01L2400/0415 ,  G01N33/54366 ,  G01N33/54393

    摘要： A method for the determination of an analyte which is a) present in a liquid sample 1 suspected of containing the analyte, and b) at least bivalent with respect to simultaneous affinity binding of at least two binding structures BSs. The method comprises formation of an affinity complex that comprises the analyte and an affinity reactant 1 that is immobilized to a solid phase. The method comprises the steps of: (i) providing a microfluidic flow path that comprises a reaction cavity containing a solid phase to which affinity reactant 1 is immobilized, (ii) providing sample 1 upstream of the cavity and flowing it through the cavity for the formation of the affinity complex under flow conditions, (iii) measuring the amount of complex formed in the solid phase by a) incorporating an analytically detectable and soluble affinity reactant 2 that comprises a binding structure BS into the complex subsequent to step (ii), and b) measuring the amount of affinity reactant 2 incorporated.

    摘要翻译： 一种用于测定分析物的方法，所述分析物是a）存在于疑似含有分析物的液体样品1中，以及b）至少两种与至少两种结合结构BS同时亲和结合的二价。 该方法包括形成包含分析物的亲和复合物和固定在固相上的亲和反应物1。 该方法包括以下步骤：（i）提供微流体流动路径，其包含含有固相的反应空腔，固相物向其中固定有亲和反应物1，（ii）在空腔上游提供样品1并将其流过腔体， 在流动条件下形成亲和络合​​物，（iii）通过以下步骤测量在固相中形成的络合物的量：a）在步骤（ii）之后，将包含结合结构BS的可分析可检测和可溶性亲和反应物2并入复合物中， 和b）测量掺入的亲和反应物2的量。

    IG-Assay
    20.
    发明申请
    IG-Assay 审中-公开

    公开(公告)号：US20070231829A1

    公开(公告)日：2007-10-04

    申请号：US11694210

    申请日：2007-03-30

    申请人： Mats Inganas

    发明人： Mats Inganas

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854

    摘要： A method of the quantitative determination of an immunoglobulin (Ig) of a certain class (IgX) in a liquid sample comprising the step of forming a complex that comprises a ternary affinity complex in which IgX is sandwiched between two affinity reactants 1 and 2 (R1 and R2, respectively).

    摘要翻译： 一种定量测定液体样品中某类（IgX）的免疫球蛋白（Ig）的方法，包括形成复合物的步骤，该复合物包含其中IgX夹在两种亲和反应物1和2之间的三元亲和络合物（R1 和R2）。