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公开(公告)号：US09353191B2
公开(公告)日：2016-05-31
申请号：US13491197
申请日：2012-06-07
CPC分类号： C08B3/12 , C08B11/08 , C08B11/12 , C08B11/20 , C08B15/005 , C08J3/075 , C08J2301/00 , C08J2301/08 , C08J2301/26 , C08J2301/28 , C08L1/08 , C08L1/284 , C08L1/286 , Y10T428/2982
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
摘要翻译： 本发明提供一种制备聚合物水凝胶的方法，包括以下步骤：（1）制备水溶性多糖衍生物和多元羧酸的水溶液; （2）任选地搅拌溶液，例如通过搅拌; （3）从溶液中分离多糖衍生物/多元羧酸复合物; 和（4）在至少约80℃的温度下加热多糖衍生物/多元羧酸复合物，从而使多糖与多元羧酸交联。 本发明还提供了通过本发明的方法制备的聚合物水凝胶。
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公开(公告)号：US20130089737A1
公开(公告)日：2013-04-11
申请号：US13491197
申请日：2012-06-07
IPC分类号： C08B3/12
CPC分类号： C08B3/12 , C08B11/08 , C08B11/12 , C08B11/20 , C08B15/005 , C08J3/075 , C08J2301/00 , C08J2301/08 , C08J2301/26 , C08J2301/28 , C08L1/08 , C08L1/284 , C08L1/286 , Y10T428/2982
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
摘要翻译： 本发明提供一种制备聚合物水凝胶的方法，包括以下步骤：（1）制备水溶性多糖衍生物和多元羧酸的水溶液; （2）任选地搅拌溶液，例如通过搅拌; （3）从溶液中分离多糖衍生物/多元羧酸复合物; 和（4）在至少约80℃的温度下加热多糖衍生物/多元羧酸复合物，从而使多糖与多元羧酸交联。 本发明还提供了通过本发明的方法制备的聚合物水凝胶。
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公开(公告)号：US20120202742A1
公开(公告)日：2012-08-09
申请号：US13007222
申请日：2011-01-14
IPC分类号： A61K31/57 , A61P15/18 , A61P5/24 , A61K31/565 , A61K38/09
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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14.发明申请METHODS AND COMPOSITIONS FOR WEIGHT MANAGEMENT AND FOR IMPROVING GLYCEMIC CONTROL 审中-公开重量管理和改进糖化控制的方法和组合公开(公告)号：US20120052151A1
公开(公告)日：2012-03-01
申请号：US13106909
申请日：2011-05-13
申请人： Alessandro Sannino , Luigi Ambrosio , Eyal S. Ron , Yishai Zohar
发明人： Alessandro Sannino , Luigi Ambrosio , Eyal S. Ron , Yishai Zohar
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A21D13/80 , A23G9/34 , A23L2/68 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L29/288 , A23L33/24 , A23L33/30 , A23V2002/00 , A61K47/38 , C08B13/00 , C08B15/005 , C08J3/075 , C08J2301/02 , C08J2301/10 , C08L1/32 , A23V2200/326 , A23V2200/32 , A23V2200/332 , A23V2200/328 , A23V2250/51082 , A23V2250/032 , A23V2200/244
摘要： The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
摘要翻译： 本发明提供了可用于体重管理和血糖控制的方法，组合物和改良食品和食品。
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公开(公告)号：US07829112B2
公开(公告)日：2010-11-09
申请号：US12125593
申请日：2008-05-22
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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公开(公告)号：US20080286322A1
公开(公告)日：2008-11-20
申请号：US12125593
申请日：2008-05-22
IPC分类号： A61F2/04
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US06204270B1
公开(公告)日：2001-03-20
申请号：US09439636
申请日：1999-11-12
申请人： Eyal S. Ron , Dov Tamarkin
发明人： Eyal S. Ron , Dov Tamarkin
IPC分类号： A61K3152
CPC分类号： A61K31/522 , A61K9/0048 , A61K31/00
摘要： A composition to treat mucosal disorders includes a therapeutically effective quantity of an anti-TNF-&agr; agent and a mucoadhessive delivery system.
摘要翻译： 用于治疗粘膜疾病的组合物包括治疗有效量的抗TNF-α剂和粘膜移行递送系统。
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公开(公告)号：US5935593A
公开(公告)日：1999-08-10
申请号：US749758
申请日：1996-10-22
申请人： Eyal S. Ron , Eric Roos , Matthew E. Schiller , Michal Orkisz , Anne Staples
发明人： Eyal S. Ron , Eric Roos , Matthew E. Schiller , Michal Orkisz , Anne Staples
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K9/00 , A61K9/20 , A61K9/22 , A61K38/47 , A61K47/38 , A61L15/60 , A61L26/00 , A61L27/52 , A61L27/54 , A61L29/14 , A61L31/14 , A61Q13/00 , A61Q19/00 , C08B15/00 , C08B31/00 , C12N5/00 , A61F2/02
CPC分类号： C08B31/006 , A61K38/47 , A61K47/38 , A61K9/0004 , A61K9/0009 , A61K9/2054 , A61L15/60 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L31/145 , C08B15/005 , C08B31/003 , C12N5/0068 , A61L2300/602 , C12N2533/30 , C12N2533/78
摘要： System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.
摘要翻译： 将生物活性物质输送到环境中的系统。 第一和第二腔室由可移动隔板分开。 第一室包括聚合物凝胶网络，其响应于环境条件例如pH而经历体积变化。 第一隔室包括用于限制聚合物凝胶网络的屏幕或膜，同时允许与环境中的流体通信。 第二隔室含有生物活性化合物或药物，其通过第二隔室中的孔输送到环境中。 当触发环境条件发生时，聚合物凝胶网络经历体积变化，从而移动可移动的分隔件，通过孔排出药物。 只有在满足适当的环境条件或触发条件时才开始进行药物传递。
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19.发明授权Apparatus and method for delivering a biologically active compound into a biological environment 失效将生物活性化合物递送到生物环境中的装置和方法
公开(公告)号：US5651979A
公开(公告)日：1997-07-29
申请号：US473218
申请日：1995-06-07
申请人： Eyal S. Ron , Matthew E. Schiller , Eric Roos
发明人： Eyal S. Ron , Matthew E. Schiller , Eric Roos
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K9/00 , A61K9/20 , A61K9/22 , A61K38/47 , A61K47/38 , A61L15/60 , A61L26/00 , A61L27/52 , A61L27/54 , A61L29/14 , A61L31/14 , A61Q13/00 , A61Q19/00 , C08B15/00 , C08B31/00 , C12N5/00 , A61F2/02
CPC分类号： C08B31/006 , A61K38/47 , A61K47/38 , A61K9/0004 , A61K9/0009 , A61K9/2054 , A61L15/60 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L31/145 , C08B15/005 , C08B31/003 , C12N5/0068 , A61L2300/602 , C12N2533/30 , C12N2533/78
摘要： System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.
摘要翻译： 将生物活性物质输送到环境中的系统。 第一和第二腔室由可移动隔板分开。 第一室包括聚合物凝胶网络，其响应于环境条件例如pH而经历体积变化。 第一隔室包括用于限制聚合物凝胶网络的屏幕或膜，同时允许与环境中的流体通信。 第二隔室含有生物活性化合物或药物，其通过第二隔室中的孔输送到环境中。 当触发环境条件出现时，聚合物凝胶网络经历体积变化，从而使可移动的隔板移动通过孔排出药物。 只有在满足适当的环境条件或触发条件时才开始进行药物传递。
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公开(公告)号：US09198897B2
公开(公告)日：2015-12-01
申请号：US11795210
申请日：2006-01-19
申请人： Marcelo Merello , Neal M. Farber , Eyal S. Ron
发明人： Marcelo Merello , Neal M. Farber , Eyal S. Ron
CPC分类号： A61K31/4409 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K31/00 , A61K31/40 , A61K31/46 , A61K47/10 , A61K47/38
摘要： The invention provides methods and compositions comprising an anti-cholinergic agent for decreasing saliva production and treating sialorrhea.
摘要翻译： 本发明提供了包含用于减少唾液产生和治疗唾液酸的抗胆碱能剂的方法和组合物。
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