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公开(公告)号：US20100197687A1
公开(公告)日：2010-08-05
申请号：US11795632
申请日：2005-12-22
申请人： Benjamin Pelcman , Kristofer Olofsson , Martins Katkevics , Vita Ozola , Edgars Suna , Ivars Kalvins , Peteris Trapencieris , Dace Katkevica , Wesley Schaal
发明人： Benjamin Pelcman , Kristofer Olofsson , Martins Katkevics , Vita Ozola , Edgars Suna , Ivars Kalvins , Peteris Trapencieris , Dace Katkevica , Wesley Schaal
IPC分类号： A61K31/5355 , C07D209/12 , A61K31/404 , C07D413/04 , C07D403/06 , A61K31/496 , C07D401/04 , A61K31/4439 , A61P29/00
CPC分类号： C07D403/04 , C07D209/30 , C07D209/42 , C07D401/04 , C07D401/06 , C07D403/14 , C07D417/06
摘要： There is provided compounds of formula I, wherein T, Y, X1, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译： 提供式I化合物，其中T，Y，X 1，R 1，R 2，R 3，R 4和R 5具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗其中抑制 MAPEG家族成员的活性是期望和/或需要的，特别是治疗炎症。
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公开(公告)号：US07705023B2
公开(公告)日：2010-04-27
申请号：US11629624
申请日：2005-06-17
申请人： Kristofer Olofsson , Benjamin Pelcman , Ivars Kalvins , Edgars Suna , Vita Ozola , Martins Katkevics
发明人： Kristofer Olofsson , Benjamin Pelcman , Ivars Kalvins , Edgars Suna , Vita Ozola , Martins Katkevics
IPC分类号： A61K31/404 , A61K31/44 , A61K31/497 , A61P29/00 , C07D209/32 , C07D401/02
CPC分类号： C07D401/04
摘要： There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译： 提供式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5和R 6具有本说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗疾病 对微粒体前列腺素E合酶-1的活性的抑制是期望的和/或需要的，特别是在治疗炎症中。
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公开(公告)号：US20090042949A1
公开(公告)日：2009-02-12
申请号：US11795624
申请日：2005-12-22
申请人： Benjamin Pelcman , Kristofer Olofsson , Martins Katkevics , Vita Ozola , Edgars Suna , Ivars Kalvins , Wesley Schaal
发明人： Benjamin Pelcman , Kristofer Olofsson , Martins Katkevics , Vita Ozola , Edgars Suna , Ivars Kalvins , Wesley Schaal
IPC分类号： A61K31/4439 , C07D209/42 , C07D401/14 , A61P29/00 , A61K31/404
CPC分类号： C07D401/04 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
摘要： There is provided compounds of formula I, wherein X1, T, Y, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译： 提供了式I化合物，其中X 1，T，Y，R 1，R 2，R 3，R 4和R 5具有本说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗其中抑制 MAPEG家族成员的活性是期望和/或需要的，特别是治疗炎症。
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公开(公告)号：US20120004244A1
公开(公告)日：2012-01-05
申请号：US13256003
申请日：2010-03-12
IPC分类号： A61K31/44 , C07D401/10 , A61K31/4439 , C07D405/10 , A61K31/443 , C07D239/42 , A61K31/505 , C07D213/79 , A61P37/08 , A61P11/00 , A61P17/00 , A61P1/00 , A61P29/00 , A61P9/00 , A61P11/02 , A61P31/04 , A61P31/12 , A61P31/10 , A61P27/02 , A61P25/00 , C07D213/74
CPC分类号： C07D405/12 , C07D213/50 , C07D213/65 , C07D213/74 , C07D401/10 , C07D409/12
摘要： There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供式I化合物，其中E1，E2a，E2b，E2c，E4，D1，D2，D3，L1，Y1，L2和Y2具有说明书中给出的含义及其药学上可接受的盐，该化合物是有用的 用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20110319431A1
公开(公告)日：2011-12-29
申请号：US13256122
申请日：2010-03-15
IPC分类号： A61K31/505 , A61K31/196 , C07D239/47 , C07D213/78 , C07C59/84 , A61P31/12 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06 , A61P9/00 , A61P27/16 , A61P27/02 , A61P17/00 , A61P1/00 , A61P13/00 , A61P25/00 , A61P7/06 , A61P31/04 , A61P31/10 , A61K31/44
CPC分类号： C07C323/63 , C07C317/48 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/50 , C07D213/65 , C07D213/74 , C07D317/46 , C07D335/02 , C07D401/10 , C07D405/12 , C07D409/12
摘要： There is provided compounds of formula I, wherein Y, ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供了式I化合物，其中Y，环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20110112193A1
公开(公告)日：2011-05-12
申请号：US12992074
申请日：2009-05-05
IPC分类号： A61K31/255 , C07C311/35 , C07C229/64 , A61K31/196 , C07C303/36 , C07C227/16 , A61P11/00 , A61P29/00 , A61P11/06 , A61P37/08 , A61P17/00 , A61P27/02 , A61P25/00 , A61P13/00 , A61P5/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P7/06 , A61P35/00
CPC分类号： C07C311/27 , C07C229/64
摘要： There is provided compounds of formula (I), wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供式（I）化合物，其中环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20130035358A1
公开(公告)日：2013-02-07
申请号：US13634221
申请日：2011-03-14
IPC分类号： A61K31/44 , A61P29/00 , A61P11/00 , A61P11/06 , A61P37/08 , A61P27/02 , A61P17/00 , A61P1/00 , A61P9/00 , A61P25/00 , A61P31/10 , A61P31/04 , A61P31/12 , C07D409/10 , A61K31/4436 , C07D405/10 , A61K31/443 , A61K31/4433 , C07D213/74
CPC分类号： C07D405/12 , C07D213/50 , C07D213/65 , C07D213/74 , C07D401/10 , C07D409/12
摘要： There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供式I化合物，其中E1，E2a，E2b，E2c，E4，D1，D2，D3，L1，Y1，L2和Y2具有说明书中给出的含义及其药学上可接受的盐，该化合物是有用的 用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20120004228A1
公开(公告)日：2012-01-05
申请号：US13256007
申请日：2010-03-12
IPC分类号： A61K31/196 , C07D213/74 , C07D401/10 , C07D413/10 , A61K31/44 , A61K31/4725 , A61K31/5377 , A61P37/08 , A61P11/06 , A61P11/00 , A61P27/02 , A61P17/00 , A61P29/00 , A61P7/00 , A61P9/00 , A61P1/00 , A61P13/00 , A61P25/00 , A61P5/00 , A61P17/02 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P7/06 , A61P35/00 , A61P19/02 , C07C229/66
CPC分类号： C07D213/50 , C07C229/52 , C07C229/66 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C237/40 , C07C251/48 , C07C311/29 , C07C317/48 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/61 , C07D213/74 , C07D303/36 , C07D309/06 , C07D309/14 , C07D317/28 , C07D317/46 , C07D317/62 , C07D335/02 , C07D401/10 , C07D401/12 , C07D405/12
摘要： There is provided compounds of formula I, wherein Y, ring A, Da, Db, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供式I化合物，其中Y，A，D，Db，D 2，D 3，L 1，Y 1，L 2，D 3，L 1， 可用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20110294853A1
公开(公告)日：2011-12-01
申请号：US13063405
申请日：2009-09-10
申请人： Benjamin Pelcman , Maria Almeida , Martins Katkevics , Peter Nilsson , Wesley Schaal , Kristofer Olofsson
发明人： Benjamin Pelcman , Maria Almeida , Martins Katkevics , Peter Nilsson , Wesley Schaal , Kristofer Olofsson
IPC分类号： A61K31/444 , A61K31/195 , A61P29/00 , C07D401/12 , A61P11/00 , C07C233/81 , C07C311/21
CPC分类号： C07D401/12 , C07C233/81 , C07C235/56 , C07C237/42 , C07C311/21
摘要： There is provided compounds of formula (I), wherein ring A, D1, D2a, D2b, D3, Y, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供式（I）化合物，其中环A，D1，D2a，D2b，D3，Y，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。
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公开(公告)号：US20110071197A1
公开(公告)日：2011-03-24
申请号：US12937799
申请日：2009-04-16
IPC分类号： A61K31/196 , C07C229/64 , C07D213/74 , C07C317/22 , C07D213/82 , C07D213/81 , C07D257/04 , A61K31/44 , A61K31/41 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06 , A61P17/00 , A61P27/02 , A61P1/00 , A61P9/00 , A61P5/00 , A61P25/00 , A61P31/04 , A61P31/12 , A61P31/10
CPC分类号： C07C233/75 , C07C229/64 , C07C233/81 , C07C235/64 , C07C237/40 , C07C311/21 , C07C311/29 , C07C311/51 , C07C317/14 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/08 , C07D213/82 , C07D307/79
摘要： There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译： 提供了式I化合物，其中环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3在说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗疾病 其中需要和/或需要抑制白细胞三烯C4合酶，特别是在治疗呼吸障碍和/或炎症中。
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