公开(公告)号：US20060052469A1

公开(公告)日：2006-03-09

申请号：US11249793

申请日：2005-10-13

申请人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

发明人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

IPC分类号： C07D249/12 ,  C08F2/46

CPC分类号： C09B69/109 ,  C08F246/00 ,  C08F290/06 ,  C08F290/14 ,  C09B69/101 ,  C09B69/105 ,  C09B69/106

摘要： Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.

公开(公告)号：US20050112563A9

公开(公告)日：2005-05-26

申请号：US09951052

申请日：2001-09-12

申请人： Phillip Cook ,  Brett Monia

发明人： Phillip Cook ,  Brett Monia

IPC分类号： A61K31/70 ,  A61K31/7125 ,  A61K38/00 ,  A61K48/00 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  C07H19/04 ,  C07H21/00 ,  C07H21/04 ,  C07K9/00 ,  C07K14/00 ,  C07K14/82 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12Q1/6813 ,  C07H21/00 ,  C07H21/04 ,  C07K14/003 ,  C07K14/82 ,  C12N15/1135 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12Q1/6816 ,  C12Q1/6832 ,  C12Q2525/125 ,  C12Q2521/319 ,  C12Q2525/101

摘要： Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and sub-sequences of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.

摘要翻译： 提供具有增加的核酸酶抗性的寡核苷酸和其它大分子，用于增加对互补链的结合亲和力的取代基和激活核糖核酸酶H酶的2'-脱氧 - 赤 - 戊呋喃糖基核苷酸的亚序列。 这样的寡核苷酸和大分子可用于诊断和其他研究目的，用于调节生物体中的蛋白质，以及诊断，检测和治疗对反义治疗剂敏感的其它病症。

公开(公告)号：US20070265224A1

公开(公告)日：2007-11-15

申请号：US11818666

申请日：2007-06-14

申请人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

发明人： Phillip Cook ,  Guangyi Wang ,  Thomas Bruice ,  Nicholas Boyle ,  Janet Leeds ,  Jennifer Brooks ,  Marija Prhavc ,  Maria Ariza ,  Patrick Fagan ,  Yi Jin ,  Vivek Rajwanshi ,  Kathleen Tucker

IPC分类号： A61K31/7072 ,  A61K31/505 ,  A61K31/7076 ,  A61P31/12 ,  A61P35/00 ,  C07H19/06 ,  C07H19/16 ,  C07D239/02 ,  A61P31/18 ,  A61P31/00 ,  A61K31/7068

CPC分类号： C07H19/04 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20

摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.

摘要翻译： 本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其含有二磷酸酯或三磷酸酯部分模拟物和任选的糖修饰和/或碱基修饰。 本发明的核苷酸模拟物以药学上可接受的盐，药学上可接受的前药或药物制剂的形式可用作抗病毒，抗微生物剂和抗癌剂。 本发明提供了一种治疗病毒感染，微生物感染和增殖性疾病的方法。 本发明还涉及包含任选与其它药物活性剂组合的本发明化合物的药物组合物。

公开(公告)号：US20070141203A1

公开(公告)日：2007-06-21

申请号：US11705348

申请日：2007-02-12

申请人： Phillip Cook

发明人： Phillip Cook

IPC分类号： A23L1/30

CPC分类号： C12G3/06 ,  A23C9/158 ,  A23L2/02 ,  A23L2/38 ,  A23L2/385 ,  A23L2/52 ,  A23L2/54 ,  A23L33/15 ,  A23V2002/00 ,  A23V2250/712

摘要： The present invention relates to beverage compositions that have the added benefit of providing a water-soluble source of Vitamin E. For example, d,l- or d-α-tocopheryl polyethylene glycol 1000 succinate (such as Vitamin E TPGS™) may be used to provide tocopheryl (i.e., vitamin E) content to beverages while concurrently maintaining beverage clarity when desired. Various additives may also be used in the beverage compositions of the present invention, such as flavoring agents, colorants, preservatives, sweeteners as well as other vitamins, minerals and/or electrolytes.

摘要翻译： 本发明涉及具有提供维生素E的水溶性来源的附加益处的饮料组合物。例如，d，l-或d-α-生育酚聚乙二醇1000琥珀酸酯（例如维生素E TPGS TM） 可以用于向饮料提供生育酚（即维生素E）含量，同时在需要时保持饮料的透明度。 也可以在本发明的饮料组合物中使用各种添加剂，例如调味剂，着色剂，防腐剂，甜味剂以及其它维生素，矿物质和/或电解质。

公开(公告)号：US20060264390A1

公开(公告)日：2006-11-23

申请号：US11496338

申请日：2006-07-31

申请人： Anne Eldrup ,  Marija Prhavc ,  Phillip Cook ,  Steven Carroll ,  David Olsen

发明人： Anne Eldrup ,  Marija Prhavc ,  Phillip Cook ,  Steven Carroll ,  David Olsen

IPC分类号： A61K31/7076 ,  C07H19/00

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

公开(公告)号：US20050272676A1

公开(公告)日：2005-12-08

申请号：US11200499

申请日：2005-08-09

申请人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LaFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

发明人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Robert LaFemina ,  Amy Simcoe ,  Carrie Rutkowski ,  Mario Valenciano

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  A61K31/712 ,  A61K38/21 ,  A61K45/00 ,  A61K45/06 ,  A61P1/16 ,  A61P31/14 ,  A61P43/00 ,  C07D473/00 ,  C07D487/02 ,  C07H20060101 ,  C07H19/00 ,  C07H19/04 ,  C07H19/048 ,  C07H19/06 ,  C07H19/067 ,  C07H19/09 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  C07H19/19 ,  C07H19/20 ,  C12N20060101

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

公开(公告)号：US20050096287A1

公开(公告)日：2005-05-05

申请号：US10876962

申请日：2004-06-25

申请人： Rahul Mehta ,  Gregory Hardee ,  Phillip Cook ,  David Ecker ,  Yali Tsai ,  Michael Templin

发明人： Rahul Mehta ,  Gregory Hardee ,  Phillip Cook ,  David Ecker ,  Yali Tsai ,  Michael Templin

IPC分类号： C12N15/09 ,  A61K9/107 ,  A61K31/7088 ,  A61K31/7125 ,  A61K47/12 ,  A61K47/24 ,  A61K47/38 ,  A61K48/00 ,  C07H21/04 ,  C12Q1/68

CPC分类号： A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/0075

摘要： The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.

公开(公告)号：US20050074771A1

公开(公告)日：2005-04-07

申请号：US10628043

申请日：2003-07-25

申请人： Phillip Cook ,  Muthiah Manoharan

发明人： Phillip Cook ,  Muthiah Manoharan

IPC分类号： C12Q1/68 ,  A61K31/712 ,  A61K48/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07J1/00 ,  C07H21/04

CPC分类号： C07H21/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07J1/00

摘要： Nucleosides and oligonucleosides functionalized to include carbamate functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the carbamate group.

摘要翻译： 功能化为包括氨基甲酸酯官能团的核苷和寡核苷酸及其衍生物。 在某些实施方案中，本发明的化合物还包括通过氨基甲酸酯基团连接到核苷上的类固醇，报道分子，报道酶，亲脂性分子，肽或蛋白质。

公开(公告)号：US20070232798A1

公开(公告)日：2007-10-04

申请号：US11685035

申请日：2007-03-12

申请人： Phillip Cook ,  Yogesh Sanghvi ,  Kelly Sprankle ,  Bruce Ross ,  Rich Griffey ,  Robert Springer

发明人： Phillip Cook ,  Yogesh Sanghvi ,  Kelly Sprankle ,  Bruce Ross ,  Rich Griffey ,  Robert Springer

IPC分类号： C07H19/06 ,  C07D401/04

CPC分类号： C07H19/06 ,  C07H21/00 ,  Y02P20/55 ,  Y02P20/582

摘要： Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

摘要翻译： 公开了寡核苷酸类似物，其中具有在2'和5'位置被修饰的嘧啶单体亚单位。 具有这些修饰的单体子单元可以在2'位置进一步修饰。 还提供了用于合成2'-O-取代的嘧啶核苷的改进方法。 该方法的特征是在路易斯酸存在下，使用具有弱亲核试剂的2,2'-脱水嘧啶核苷或2S，2'-脱水嘧啶核苷进行烷基化。

公开(公告)号：US20070032598A1

公开(公告)日：2007-02-08

申请号：US11544153

申请日：2006-10-06

申请人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook ,  Jos De Wit ,  Larry Johnson

发明人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook ,  Jos De Wit ,  Larry Johnson

IPC分类号： C08F8/30 ,  C08L75/00

CPC分类号： C08G18/8108 ,  C08F220/00 ,  C08F283/00 ,  C08F290/00 ,  C08G18/38 ,  C09B1/28 ,  C09B1/32 ,  C09B1/58 ,  C09B67/0004 ,  C09B69/101 ,  C09D4/06

摘要： Disclosed are thermally-stable, anthraquinone colorant compounds (dyes) which contain one or more vinyl groups which render the compounds copolymerizable with reactive vinyl monomers to produce colored, polymeric compositions such as acrylate and methacrylate polymeric materials. The compounds possess good fastness (stability) to ultraviolet (UV) light, good solubility in vinyl monomers, good color strength and excellent thermal stability. Also disclosed are (1) coating composition comprising (i) one or more polymerizable vinyl compounds, (ii) one or more of the dye compounds described above, and (iii) a photoinitiator and (2) polymeric materials, i.e., polymers derived from one or more acrylic acid esters, one or more methacrylic acid esters, one or more other polymerizable vinyl compounds or mixtures of any two or more thereof, having copolymerized therein one or more of the anthraquinone colorant compounds.

摘要翻译： 公开了热稳定的蒽醌着色剂化合物（染料），其含有一个或多个乙烯基，使得化合物与反应性乙烯基单体共聚以产生着色的聚合物组合物，例如丙烯酸酯和甲基丙烯酸酯聚合物材料。 该化合物对紫外线（UV）光具有良好的牢度（稳定性），在乙烯基单体中的良好溶解性，良好的着色强度和优异的热稳定性。 还公开了（1）涂料组合物，其包含（i）一种或多种可聚合乙烯基化合物，（ii）一种或多种上述染料化合物，和（iii）光引发剂和（2）聚合物材料，即衍生自 一种或多种丙烯酸酯，一种或多种甲基丙烯酸酯，一种或多种其它可聚合乙烯基化合物或其任何两种或多种的混合物，其中共聚有一种或多种蒽醌着色剂化合物。