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11.发明申请Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 审中-公开小分子27875,22025,27420,17906,16319,55092和10218分子及其用途公开(公告)号：US20060009632A1
公开(公告)日：2006-01-12
申请号：US11226701
申请日：2005-09-14
申请人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
发明人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
IPC分类号： C07H21/04
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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12.发明申请26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor 有权26199,33530,3949,47148,50226,58764,612113,32144,32235,23565,13305,14911,86216,25206和8843分子及其用途公开(公告)号：US20070065848A1
公开(公告)日：2007-03-22
申请号：US11493347
申请日：2006-07-26
申请人： Rachel Meyers , Kyle MacBeth , Rory Curtis , Laura Rudolph-Owen , Nadine Weich , Peter Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph Carroll
发明人： Rachel Meyers , Kyle MacBeth , Rory Curtis , Laura Rudolph-Owen , Nadine Weich , Peter Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph Carroll
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/001 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/0006 , C12N9/10 , C12N9/1048 , C12N9/1096 , C12N9/12 , C12N9/1205 , C12N9/16 , C12N9/48 , C12N9/80 , C12N2799/021 , C12Q1/32 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N2500/10 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US20070212728A1
公开(公告)日：2007-09-13
申请号：US11800457
申请日：2007-05-04
CPC分类号： C12N9/0022 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , C12N9/00 , C12N9/0006 , C12N9/16 , C12N9/20 , C12N9/6421 , C12N9/88 , C12N15/52 , C12Q1/008 , C12Q1/25 , C12Q1/527
摘要： The invention provides isolated nucleic acids molecules, designated BRE nucleic acid molecules, which encode novel biotin enzyme-related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BRE nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a BRE gene has been introduced or disrupted. The invention still further provides isolated BRE proteins, fusion proteins, antigenic peptides and anti-BRE antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为BRE核酸分子，其编码新的生物素酶相关分子。 本发明还提供了反义核酸分子，含有BRE核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及引入或破坏BRE基因的非人类转基因动物。 本发明还进一步提供了分离的BRE蛋白，融合蛋白，抗原肽和抗BRE抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US20060040357A1
公开(公告)日：2006-02-23
申请号：US11245400
申请日：2005-10-06
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US20070048784A1
公开(公告)日：2007-03-01
申请号：US11591659
申请日：2006-11-01
CPC分类号： C12Q1/6883 , C12N9/82 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26443 and 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 and 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or 46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的人水解酶家族成员的分离的核酸分子，命名为26443和46873核酸分子。 本发明还提供了反义核酸分子，含有26443和46873核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及引入或破坏了26443和46873基因的非人类转基因动物。 本发明还进一步提供分离的26443和46873蛋白，融合蛋白，抗原肽和抗26443或46873抗体。 还提供了利用本发明组合物的诊断方法。
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16.发明申请Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecles, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor 审中-公开编码黑素瘤相关抗原分子，氨基转移酶分子，ATP酶分子，酰基转移酶分子，吡哆醛 - 磷酸依赖性酶分子的新型核酸序列及其用途公开(公告)号：US20070099230A1
公开(公告)日：2007-05-03
申请号：US11636665
申请日：2006-12-08
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： G01N33/5743 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N9/1029 , C12N9/1096 , C12N9/14 , C12N9/90
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US20080027147A1
公开(公告)日：2008-01-31
申请号：US11786411
申请日：2007-04-11
申请人： Rachel Meyers , Mark Williamson , Kevin Leiby , Rosana Kepeller-Libermann , Peter Olandt , Kyle MacBeth , Laura Rodolph-Owen , Fong-Ying Tsai , John Hunter
发明人： Rachel Meyers , Mark Williamson , Kevin Leiby , Rosana Kepeller-Libermann , Peter Olandt , Kyle MacBeth , Laura Rodolph-Owen , Fong-Ying Tsai , John Hunter
IPC分类号： A61K47/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N15/00 , C12N5/06 , C12N9/00 , C12N9/99 , C12P21/04 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。 本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。 本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06638721B2
公开(公告)日：2003-10-28
申请号：US09799875
申请日：2001-03-06
IPC分类号： C12Q168
CPC分类号： C12N9/1205 , A61K38/00 , C07C51/215 , C07C57/04
摘要： The invention relates to novel kinase nucleic acid sequences and proteins. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及新型激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
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19.发明申请公开(公告)号：US20050203049A1
公开(公告)日：2005-09-15
申请号：US11120749
申请日：2005-05-03
申请人： Rachel Meyers , Mark Williamson
发明人： Rachel Meyers , Mark Williamson
CPC分类号： C12N9/1048 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 47169 and 33935 nucleic acid molecules, which encode novel glycosyl transferases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47169 and 33935 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 47169 or 33935 gene has been introduced or disrupted. The invention still further provides isolated 47169 and 33935 proteins, fusion proteins, antigenic peptides and anti-47169 and anti-33935 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的糖基转移酶的分离的核酸分子，命名为47169和33935核酸分子。 本发明还提供了反义核酸分子，含有47169和33935核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了47169或33935基因的非人转基因动物。 本发明还进一步提供分离的47169和33935蛋白，融合蛋白，抗原肽和抗-47169和抗-33935抗体。 还提供了利用本发明组合物的诊断方法。
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20.发明申请14400, 2838, 14618, 15334, 14274, 32164, 39404, 38911, 26904, 31237, 18057, 16405, 32705, 23224, 27423, 32700, 32712 and 12216, novel seven-transmembrane proteins/G-protein coupled receptors 审中-公开14400,2838,14618,15334,14274,32164,39404,38911,26904,313237,18057,16405,32705,23224,27423,32700,32712和12216，新型七跨膜蛋白/ G蛋白偶联受体公开(公告)号：US20080051322A1
公开(公告)日：2008-02-28
申请号：US11810360
申请日：2007-06-05
申请人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
发明人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
IPC分类号： A61K38/16 , A61K38/00 , A61P43/00 , C07H21/04 , C07K16/00 , C12N5/00 , C12P21/04 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/566 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K14/723 , C07K2319/00 , C12N9/16 , G01N2333/726
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译： 本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。 本发明还涉及编码受体的多核苷酸。 本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。 本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生受体多肽和多核苷酸的方法。
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