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公开(公告)号：US20090137404A1
公开(公告)日：2009-05-28
申请号：US11981767
申请日：2007-10-31
CPC分类号： C12Q1/6874 , C07H21/04 , C07K1/047 , C12Q1/6806 , C12Q1/682 , C12Q1/6837 , C12Q1/6869 , C12Q2525/151 , C12Q2525/313 , C12Q2531/125 , C12Q2565/513 , G01N15/1404 , G01N15/1434 , Y10S977/778 , Y10S977/789 , Y10S977/792 , Y10S977/88 , Y10S977/882 , C12Q2521/307 , C12Q2525/161 , C12Q2535/122 , C12Q2563/179 , C12Q2565/514
摘要： Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques.
摘要翻译： 提供单个分子的随机阵列用于进行大规模分析，特别是生物分子，例如基因组DNA，cDNAs，蛋白质等。 在一个方面，本发明的阵列包括随机设置在离散间隔开的区域的规则阵列上的DNA片段的并列物质，使得基本上所有这些区域都包含不超过单个并联体。 优选地，这样的区域具有基本上小于1mum2的面积，并且具有最近的相邻距离，其允许每厘米每分钟109个单分子的光学分辨率。 许多分析化学物质可以应用于本发明的随机阵列，包括杂交化学测序，合成化学测序，SNP检测化学等，以大大扩展这些技术的规模和潜在应用。
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公开(公告)号：US20090137414A1
公开(公告)日：2009-05-28
申请号：US11982467
申请日：2007-10-31
CPC分类号： C12Q1/6874 , C07H21/04 , C07K1/047 , C12Q1/6806 , C12Q1/682 , C12Q1/6837 , C12Q1/6869 , C12Q2525/151 , C12Q2525/313 , C12Q2531/125 , C12Q2565/513 , G01N15/1404 , G01N15/1434 , Y10S977/778 , Y10S977/789 , Y10S977/792 , Y10S977/88 , Y10S977/882 , C12Q2521/307 , C12Q2525/161 , C12Q2535/122 , C12Q2563/179 , C12Q2565/514
摘要： Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques.
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公开(公告)号：US20070099208A1
公开(公告)日：2007-05-03
申请号：US11451691
申请日：2006-06-13
申请人： Radoje Drmanac , Matthew Callow , Snezana Drmanac , Brian Hauser , George Yeung
发明人： Radoje Drmanac , Matthew Callow , Snezana Drmanac , Brian Hauser , George Yeung
CPC分类号： C12Q1/6874 , C07H21/04 , C07K1/047 , C12Q1/6806 , C12Q1/682 , C12Q1/6837 , C12Q1/6869 , C12Q2525/151 , C12Q2525/313 , C12Q2531/125 , C12Q2565/513 , G01N15/1404 , G01N15/1434 , Y10S977/778 , Y10S977/789 , Y10S977/792 , Y10S977/88 , Y10S977/882 , C12Q2521/307 , C12Q2525/161 , C12Q2535/122 , C12Q2563/179 , C12Q2565/514
摘要： Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques.
摘要翻译： 提供单个分子的随机阵列用于进行大规模分析，特别是生物分子，例如基因组DNA，cDNAs，蛋白质等。 在一个方面，本发明的阵列包括随机地设置在离散的间隔开的区域的规则阵列上的DNA片段的连接体，使得基本上所有这些区域都包含不超过单个并联体。 优选地，这样的区域具有基本上小于1mum 2的面积，并且具有最接近的距离，其允许每厘米2的单分子的光学分辨率 。 许多分析化学物质可以应用于本发明的随机阵列，包括杂交化学测序，合成化学测序，SNP检测化学等，以大大扩展这些技术的规模和潜在应用。
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公开(公告)号：US06635742B1
公开(公告)日：2003-10-21
申请号：US09653274
申请日：2000-08-31
申请人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C07K1600
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/4703 , C07K14/70503 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。
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公开(公告)号：US06476211B1
公开(公告)日：2002-11-05
申请号：US09557800
申请日：2000-04-25
申请人： John Ford , Julio J. Mulero , George Yeung
发明人： John Ford , Julio J. Mulero , George Yeung
IPC分类号： C07H2104
CPC分类号： C12N9/14 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/70596 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing CD39-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生CD39样多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US20120308702A1
公开(公告)日：2012-12-06
申请号：US13467568
申请日：2012-05-09
CPC分类号： A21C11/006 , A21C5/00 , A21C9/04 , A21D8/02 , A21D13/41 , G07F11/70 , G07F17/0078
摘要： Automated apparatus for preparing pizza, and method of operating same. A customer selects a type of pizza, such as toppings or crust style. The apparatus slices and defrosts dough, applies cheese, slices and applies toppings, and cooks the pizza to order. The cooked pizza is packaged for delivery to the customer and may include a separate cutting apparatus. Proper temperature of hot and cold sections is maintained while ingredients are stored and as the pizza is cooked. The process is monitored and controlled by one or more processors.
摘要翻译： 制作比萨饼的自动化装置及其操作方法。 客户选择一种类型的比萨饼，如浇头或地壳样式。 设备切片和除霜面团，应用乳酪，切片和应用浇头，并烹制比萨饼以订购。 煮熟的比萨饼被包装以交付给客户，并且可以包括单独的切割装置。 在保存成分的同时保持适当的冷热段温度，同时烹饪比萨饼。 该过程由一个或多个处理器监视和控制。
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公开(公告)号：US20090111705A1
公开(公告)日：2009-04-30
申请号：US11934697
申请日：2007-11-02
申请人： Andrew Sparks , Arnold Oliphant , George Yeung
发明人： Andrew Sparks , Arnold Oliphant , George Yeung
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another by employing selective capture of defined molecules. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译： 在此描述和要求保护的方面提供了通过采用选择性捕获限定的分子将多个DNA适配器插入到相对于彼此的限定位置和取向的环状靶DNA群中的方法。 然后将所得多连接体构建体用于大规模并行核酸测序技术。
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公开(公告)号：US07001731B2
公开(公告)日：2006-02-21
申请号：US10101673
申请日：2002-03-18
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
CPC分类号： C07K14/7158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.
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公开(公告)号：US08710408B2
公开(公告)日：2014-04-29
申请号：US13467568
申请日：2012-05-09
CPC分类号： A21C11/006 , A21C5/00 , A21C9/04 , A21D8/02 , A21D13/41 , G07F11/70 , G07F17/0078
摘要： Automated apparatus for preparing pizza, and method of operating same. A customer selects a type of pizza, such as toppings or crust style. The apparatus slices and defrosts dough, applies cheese, slices and applies toppings, and cooks the pizza to order. The cooked pizza is packaged for delivery to the customer and may include a separate cutting apparatus. Proper temperature of hot and cold sections is maintained while ingredients are stored and as the pizza is cooked. The process is monitored and controlled by one or more processors.
摘要翻译： 制作比萨饼的自动化装置及其操作方法。 客户选择一种类型的比萨饼，如浇头或地壳样式。 设备切片和除霜面团，应用乳酪，切片和应用浇头，并烹制比萨饼以订购。 煮熟的比萨饼被包装以交付给客户，并且可以包括单独的切割装置。 在保存成分的同时保持适当的冷热段温度，同时烹饪比萨饼。 该过程由一个或多个处理器监视和控制。
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公开(公告)号：US06818754B1
公开(公告)日：2004-11-16
申请号：US10461791
申请日：2003-06-12
申请人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C12Q168
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/4703 , C07K14/70503 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。
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