公开(公告)号：US5234915A

公开(公告)日：1993-08-10

申请号：US587240

申请日：1990-09-24

Applicant: Rajiv Mathur ,  Donald F. H. Wallach

Inventor： Rajiv Mathur ,  Donald F. H. Wallach

IPC: A61F13/15 ,  A61K47/38 ,  A61K47/48 ,  A61L15/28 ,  A61L26/00 ,  C08B15/00

CPC classification number: C08B15/005 ,  A61F13/15252 ,  A61K47/38 ,  A61K47/4823 ,  A61L15/28 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/009 ,  A61F2013/51061 ,  A61F2013/530649 ,  A61F2013/530795 ,  A61F2013/53481 ,  A61F2013/8438 ,  A61F2013/8452 ,  A61L2300/406 ,  A61L2300/602 ,  A61L2300/802

Abstract: A new gel-like composition of matter containing a complex carbohydrate with a high degree of carboxyl substitution cross-linked by an organic cross-linker has been developed. The cross-linkers have complex ring structures, e.g., polynuclear or heterocyclic compounds, which permit development of two distinct partial positive charges under conditions where a carbohydrate is negatively charged. Antibiotics are the preferred cross-linking agents and a method of sustained release of the antibodies is also disclosed.

Abstract translation: 已经开发了含有通过有机交联剂交联的高度羧基取代的复合碳水化合物的新的凝胶状组合物。 交联剂具有复杂的环结构，例如多核或杂环化合物，其允许在碳水化合物带负电的条件下开发两种不同的部分正电荷。 抗生素是优选的交联剂，还公开了抗体的持续释放的方法。

公开(公告)号：US5213805A

公开(公告)日：1993-05-25

申请号：US735645

申请日：1991-07-25

Applicant: Donald F. H. Wallach ,  Rajiv Mathur

Inventor： Donald F. H. Wallach ,  Rajiv Mathur

IPC: A01N47/48 ,  A61K9/127

CPC classification number: A61K9/1272 ,  A01N47/48 ,  Y10T428/2984

Abstract: The present invention concerns lipid vesicles having dimethylamides as their primary structural lipid. Preferred dimethylamides useful in the invention are DMATO and DMASO oils. These vesicles are useful as carriers of water immiscible oily material such as fungicides. In a most preferred aspect, the invention has DMATO vesicles with TCMTB as a fungicide in trapped therein. The vesicles can be made rapidly and provide aqueous dispersion of these materials without the need for additional organic solvents.

Abstract translation: 本发明涉及具有二甲酰胺作为其主要结构脂质的脂质囊泡。 用于本发明的优选的二甲基酰胺是DMATO和DMASO油。 这些囊泡可用作水不混溶油性物质如杀真菌剂的载体。 在最优选的方面，本发明具有DMATO囊泡，其中TCMTB作为杀真菌剂被捕获。 可以快速制备囊泡，并提供这些材料的水性分散体，而不需要额外的有机溶剂。

公开(公告)号：US20070148226A1

公开(公告)日：2007-06-28

申请号：US11682602

申请日：2007-03-06

Applicant: Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

Inventor： Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

IPC: A61K36/185 ,  A61K9/127

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/127 ,  A61K36/29 ,  A61Q19/007

Abstract: The present invention provides a skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of Mahonia aquifolium.

Abstract translation: 本发明提供一种在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 本发明还提供了一种获得马鞭草提取物的方法。

公开(公告)号：US06309664B1

公开(公告)日：2001-10-30

申请号：US09396535

申请日：1999-09-15

Applicant: Rajiv Mathur ,  Nadya Lawrence

Inventor： Rajiv Mathur ,  Nadya Lawrence

IPC: A61K9127

CPC classification number: A61Q17/00 ,  A61K8/14 ,  A61K8/31 ,  Y10S514/847 ,  Y10T428/2984

Abstract: A fluid preparation of petrolatum capable of being sprayed on to a surface. The preparation includes paucilamellar lipid vesicles containing the petrolatum. Preferably, petrolatum comprises about 20-30% or more of the total weight of the vesicles. Methods of protecting the skin of mammals using the fluid preparation of petrolatum are also discussed.

Abstract translation: 能够喷洒在表面上的凡士林的流体制剂。 该制剂包括含有凡士林的薄膜脂质囊泡。 优选地，凡士林含有囊泡总重量的约20-30％或更多。 还讨论了使用凡士林流体制剂保护哺乳动物皮肤的方法。

公开(公告)号：US6080211A

公开(公告)日：2000-06-27

申请号：US252546

申请日：1999-02-19

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: F02M25/00 ,  C10L1/10 ,  C10L1/12 ,  C10L1/18 ,  C10L1/182 ,  C10L1/19 ,  C10L1/24 ,  C10L1/26 ,  C10L1/32 ,  C10L10/02 ,  C10L1/14

CPC classification number: C10L10/02 ,  C10L1/10 ,  C10L1/125 ,  C10L1/1258 ,  C10L1/1266 ,  C10L1/18 ,  C10L1/1824 ,  C10L1/1857 ,  C10L1/19 ,  C10L1/1985 ,  C10L1/24 ,  C10L1/26

Abstract: Liquid energy sources, e.g., liquid fuels comprising lipid vesicles having fuel additives such as water are disclosed herein. The liquid energy sources, methods for preparation, and methods of enhancing engine performance disclosed herein employing the lipid vesicles result in enhanced fuel efficiency and/or lowered engine emissions. The invention further relates to liquid energy sources containing such additives which further comprise a polymeric dispersion assistant, which reduces the interfacial tension and coalescence of vesicles during dispersion process and storage, and thereby provide transparent looks to the liquid energy source.

公开(公告)号：US5776536A

公开(公告)日：1998-07-07

申请号：US772354

申请日：1996-12-23

Applicant: Paul A. Tremblay ,  Rajiv Mathur

Inventor： Paul A. Tremblay ,  Rajiv Mathur

IPC: A23G1/00 ,  A23G1/30 ,  A23G1/32 ,  A23G1/36 ,  A23L1/035

CPC classification number: A23G1/30 ,  A23G1/325 ,  A23G1/36 ,  Y10S426/804

Abstract: A reduced fat chocolate preparation comprising lipid vesicles is disclosed. Also disclosed is a method of manufacturing the reduced fat chocolate preparation. The chocolate has less fat than regular chocolate and a higher percentage of water.

Abstract translation: 公开了包含脂质囊泡的还原脂肪巧克力制剂。 还公开了制备减肥脂巧克力制剂的方法。 巧克力比常规巧克力的脂肪少，水分含量较高。

公开(公告)号：US5756014A

公开(公告)日：1998-05-26

申请号：US838633

申请日：1997-04-11

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/97 ,  A61K8/98 ,  A61K9/127 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  B01J13/02 ,  B01J13/06

CPC classification number: B01J13/02 ,  A61K8/14 ,  A61K8/39 ,  A61K9/1272 ,  A61Q1/06 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989

Abstract: Lipid vesicles which remain stable at high temperatures are disclosed. The vesicles contain as a component of their lipid bilayers at least one ethoxylated alcohol having a linear C20-C50 carbon chain. Also disclosed is a method of making the vesicles. The lipid vesicles are useful in forming cosmetic and dermatologic preparations, such as lipstick, which are processed at high temperatures (e.g., at 80.degree. C. or above) during manufacture.

Abstract translation: 公开了在高温下保持稳定的脂质囊泡。 囊泡含有至少一种具有直链C20-C50碳链的乙氧基化醇作为它们的脂双层的组分。 还公开了制备囊泡的方法。 脂质囊泡可用于形成化妆品和皮肤病学制剂，例如唇膏，其在制造过程中在高温（例如，80℃或更高）下加工。

公开(公告)号：US5490985A

公开(公告)日：1996-02-13

申请号：US210645

申请日：1994-03-18

Applicant: Donald F. H. Wallach ,  Rajiv Mathur ,  Jean Philippot ,  Surendra Kumar

Inventor： Donald F. H. Wallach ,  Rajiv Mathur ,  Jean Philippot ,  Surendra Kumar

IPC: A61K9/127 ,  A61K33/10 ,  A61K31/695 ,  A61K33/06 ,  A61K33/12

CPC classification number: A61K9/1272 ,  A61K33/10

Abstract: An antacid product having extended duration of residence in the gastric and upper intestinal systems has been developed. This antacid product includes a blend of 10-70% by volume nonphospholipid lipid vesicles, with a particulate base. An antiflatulence agent may also be included. A method of providing extended duration amelioration of acid build up in the gastric and upper intestinal tract using this product is also disclosed.

Abstract translation: 已经开发了在胃和上肠系统中延长持续时间的抗酸产品。 该抗酸产品包括10-70体积％的非脂质脂质囊泡与颗粒基质的混合物。 还可以包括抗溢流剂。 还公开了使用该产品在胃和上肠道中延长持续时间改善酸积累的方法。

公开(公告)号：US5405615A

公开(公告)日：1995-04-11

申请号：US148885

申请日：1993-11-08

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/14 ,  A61K8/92 ,  A61K9/127 ,  A61K47/06 ,  A61K47/26 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  B01J13/02

CPC classification number: A61Q19/08 ,  A61K8/14 ,  A61K8/922 ,  A61K9/1272 ,  A61Q19/00 ,  A61Q5/12 ,  Y10T428/2984

Abstract: Disclosed are lipid vesicles containing a blend of amphiphiles, including sucrose distearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract translation: 公开了在脂质双层中含有两亲物（包括蔗糖二硬脂酸酯）的共混物的脂质囊泡。 囊泡可以具有水或油填充的中心腔，并且特别可用于递送皮肤病学，化妆品和药物制剂。 还公开了这些囊泡的制造方法。

公开(公告)号：US07205006B2

公开(公告)日：2007-04-17

申请号：US10669416

申请日：2003-09-25

Applicant: Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

Inventor： Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

IPC: A61K51/00 ,  A61K31/74 ,  A01N65/00

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/127 ,  A61K36/29 ,  A61Q19/007

Abstract: A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of Mahonia aquifolium.

Abstract translation: 一种在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 本发明还提供了一种获得马鞭草提取物的方法。