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公开(公告)号：US5514069A
公开(公告)日：1996-05-07
申请号：US172131
申请日：1993-12-22
CPC分类号： B04B5/0442 , B04B2005/045 , B04B2005/0492 , F02B2075/025
摘要： An umbilicus conveys fluid between a stationary body and a rotating body in a small, compact operating environment. The umbilicus comprises an elongated body including a proximal end, a distal end, and a middle region between the proximal and distal ends. A first support block is attached to the proximal end. A second support block is attached to the distal end. The first support block includes a strain relief sleeve. The umbilicus is otherwise free of any other strain relief sleeve. A thrust bearing member in the middle region spaced apart from the strain relief sleeve and the distal end. The umbilicus is otherwise free of any other thrust bearing member. The thrust bearing member has an inner annular body, an outer annular body about the inner annular body, and an array of ball bearings between the inner and outer annular bodies. The ball bearings support the inner annular body for rotation relative to the outer annular body.
摘要翻译： 脐带在小型，紧凑的操作环境中在固定体和旋转体之间输送流体。 脐带包括细长体，其包括近端，远端和近端和远端之间的中间区域。 第一支撑块附接到近端。 第二支撑块附接到远端。 第一支撑块包括应变消除套筒。 脐管否则没有任何其他应变消除套筒。 在中间区域中的推力轴承构件与应变消除套筒和远端间隔开。 脐管否则没有任何其他推力轴承构件。 推力轴承构件具有内环形体，围绕内环形体的外环形体，以及在内外环形体之间的一组球轴承。 球轴承支撑内环形体，以相对于外环形体旋转。
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公开(公告)号：US5462416A
公开(公告)日：1995-10-31
申请号：US173517
申请日：1993-12-22
CPC分类号： A61M1/3693 , A61M1/3696 , F04B43/1253 , F04B7/0076 , A61M2205/12 , A61M2205/128 , F02B2075/025 , F04B2205/01 , F04B2205/05
摘要： A cassette serves in association with one or more peristaltic pumps to centralize pumping, valving, and pressure sensing functions. The cassette includes a housing having first and second pump ports. A flexible tubing loop extends between the first and second pump ports outside the housing for engagement with an external peristaltic pump element. A liquid port on the housing attaches to a length of tubing that also extends outside the housing. Liquid passages within the housing that establish communication among the liquid port, the first pump port, and the second pump port. Valve stations formed within the housing are responsive to the application of external force for controlling liquid flow through the liquid passages. A sensing chamber is formed within the housing along at least one liquid passage. The sensing chamber transmits information regarding liquid pressure present within the one liquid passage to an external sensing element.
摘要翻译： 一个盒子与一个或多个蠕动泵联合起来以集中泵送，阀门和压力感测功能。 盒包括具有第一和第二泵口的壳体。 柔性管道环在壳体外部的第一和第二泵口之间延伸以与外部蠕动泵元件接合。 壳体上的液体端口连接到也延伸到壳体外部的一段管道。 壳体内的液体通道，其在液体端口，第一泵口和第二泵口之间建立通信。 形成在壳体内的阀站响应于施加外力来控制液体流过液体通道。 感测室沿着至少一个液体通道形成在壳体内。 感测室将关于一个液体通道内存在的液体压力的信息传送到外部感测元件。
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13.发明授权Blood processing systems with improved data transfer between stationary and rotating elements 失效血液处理系统具有改进的固定和旋转元件之间的数据传输
公开(公告)号：US5316666A
公开(公告)日：1994-05-31
申请号：US108550
申请日：1993-08-19
申请人： Richard I. Brown , John T. Foley
发明人： Richard I. Brown , John T. Foley
IPC分类号： A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/00 , B04B5/04 , B04B7/08 , B04B11/04 , B04B13/00 , G01D5/347 , G01D5/34
CPC分类号： B01D17/0217 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , G01D5/34715 , A61M1/025 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： Systems transmit a control signal between a rotating element and a stationary element of a blood separation centrifuge. The systems employ a sensor mechanism carried by one of the rotating and stationary elements. The sensor mechanism senses an operating condition that is subject to change. The sensor mechanism generates a first output signal that varies according to changes in the sensed operating condition. A first data transfer component on the one element that carries the sensor mechanism emits energy to the other element without mechanical contact with the other element. The first data transfer mechanism modulates the emitted energy according to variations occurring in the intensity of the first output signal. A second data transfer component on the other element receives the modulated energy emitted by the first data transfer component. The second data transfer component demodulates the detected energy to generate a second output signal that, like the first output signal, varies according to the changes in the sensed operating condition.
摘要翻译： 系统在血液分离离心机的旋转元件和静止元件之间传输控制信号。 系统采用由旋转和静止元件中的一个承载的传感器机构。 传感器机构感测到可能发生变化的操作状态。 传感器机构产生根据感测到的操作条件的变化而变化的第一输出信号。 携带传感器机构的一个元件上的第一数据传送部件向另一个元件发射能量，而不与另一元件机械接触。 第一数据传输机制根据在第一输出信号的强度中发生的变化来调制发射的能量。 另一元件上的第二数据传输部件接收由第一数据传输部件发射的调制能量。 第二数据传送组件解调检测到的能量，以产生第二输出信号，其与第一输出信号一样，根据感测到的操作条件的变化而变化。
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公开(公告)号：US4758193A
公开(公告)日：1988-07-19
申请号：US58085
申请日：1987-06-04
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： H01J29/06
CPC分类号： H01J29/06
摘要： Internal magnetic shield for color television picture tube has a pair of slot-shaped openings, facing each other above and below the Z axis, and an oblong-shaped aperture surrounding the Z axis, having a length-to-width ratio of about 1.7 to 2.1.
摘要翻译： 用于彩色电视显像管的内部磁屏蔽具有一对在Z轴上方和下方彼此相对的槽形开口，以及围绕Z轴的长圆形孔，其长宽比为约1.7至 2.1。
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公开(公告)号：US4680025A
公开(公告)日：1987-07-14
申请号：US833530
申请日：1984-11-27
申请人： Robert J. Kruger , Richard I. Brown
发明人： Robert J. Kruger , Richard I. Brown
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2209/06
摘要： A blood component collection system and method each utilizes centrifugation to first separate whole blood into red blood cells and platelet-rich plasma. Noncentrifugal separation is then utilized to further separate the platelet-rich plasma into platelet concentrate and plasma which is virtually free of platelets. The system and method are applicable for use in association with both batch and continuous flow procedures.
摘要翻译： 血液成分收集系统和方法各自利用离心法首先将全血分离成红细胞和富血小板血浆。 然后使用非离心分离来进一步将富含血小板的血浆分离成实质上不含血小板的血小板浓缩物和血浆。 该系统和方法适用于与批次和连续流程相关联的使用。
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公开(公告)号：US07708710B2
公开(公告)日：2010-05-04
申请号：US10826420
申请日：2004-04-16
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/302 , A61M1/3693
摘要： Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
摘要翻译： 公开了将全血收集和分离成一个或多个组分的方法。 提供了一种一次性血液分离流体回路，其适于与可重复使用的分离控制器配合。 流体回路包括用于与血液源连通的流体流动路径和与流体流动路径流体连通的至少一个容器。 流体流动路径连接到血液源，并且全部血液的数量被收集在容器和流体回路内的另一个位置。 然后将源从一次性流体回路断开。 全血的量是离心处理的，处理至少一部分数量从源头与流体回路断开之后开始。
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公开(公告)号：US07396452B2
公开(公告)日：2008-07-08
申请号：US11427402
申请日：2006-06-29
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
CPC分类号： A61M1/3693 , A61M1/3696
摘要： An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.
摘要翻译： 一种装置包括将包含具有不同密度的第一和第二组分的第一流体输送到旋转室中的入口，使得界面在第一位置处在这些部件的至少部分之间形成。 至少一个出口去除第一和第二组分中的至少一个。 控制器适于引入第一流体并且可操作以将界面从第一位置移动到第二位置，并且将界面从朝向第一位置的方向从第二位置移动并将界面返回到第二位置。 该控制器可操作以至少部分地基于界面从第二位置移动到第二位置之间的时间间隔来确定第一或第二组件的流量。 至少一个感测组件适于感测界面的位置。
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公开(公告)号：US07001321B1
公开(公告)日：2006-02-21
申请号：US09050614
申请日：1998-03-30
申请人： Richard I. Brown , Ying-Cheng Lo
发明人： Richard I. Brown , Ying-Cheng Lo
IPC分类号： B04B7/12
CPC分类号： B04B5/0442 , B04B5/0428 , B04B2005/045 , B04B2005/0492
摘要： A fluid processing assembly can be easily inserted into and removed from a rotatable centrifuge channel. The processing assembly comprises a processing container and a carrier. The processing container has flexibility and, in use, occupies the channel to receive fluids for separation in the centrifugal field. The carrier retains the processing container outside the channel in a flexed condition conforming to the channel. The carrier resists deformation of the processing container during its insertion into or removal from the channel.
摘要翻译： 流体处理组件可以容易地插入到可旋转的离心机通道中并从旋转离心机通道中移除。 处理组件包括处理容器和载体。 处理容器具有柔性，并且在使用中占据通道以接收在离心场中分离的流体。 承运人将处理容器保持在通道外，处于符合通道的弯曲状态。 载体抵抗处理容器在其插入或从通道移除时的变形。
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公开(公告)号：US06884228B2
公开(公告)日：2005-04-26
申请号：US09800206
申请日：2001-03-06
申请人： Richard I. Brown , Kyungyoon Min , Rohit Vishnoi , Sandra Thom , Liam Farrell , Tom Westberg
发明人： Richard I. Brown , Kyungyoon Min , Rohit Vishnoi , Sandra Thom , Liam Farrell , Tom Westberg
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/0218 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , A61M2205/12 , A61M2209/082 , A61M2209/084
摘要： Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.
摘要翻译： 公开了用于处理血液和其它流体的自动化系统和方法。 该系统和方法利用从两个或更多个电路中的一个中选择的一次性流体回路。 电路安装在可重复使用的硬件组件或模块上。 该系统包括可编程控制器，其包括与流体回路一起使用的程序。
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公开(公告)号：US06354291B1
公开(公告)日：2002-03-12
申请号：US09612164
申请日：2000-07-08
申请人： Richard I. Brown , David S. Brown
发明人： Richard I. Brown , David S. Brown
IPC分类号： B63C1102
CPC分类号： B63C11/2227 , B63C11/186
摘要： A second stage diving regulator of the type used by scuba divers is provided. The regulator comprises a regulator housing and a mouthpiece. The regulator housing includes an inhalation chamber having a port, and a demand valve that releases air to the port in response to inhalation through the port. The mouthpiece comprises a unitary housing attachable to the regulator housing and includes a one-way exhalation pathway, thus obviating the need for an exhalation pathway in the regulator housing itself. Inhalation no-return valves can be additionally incorporated into the fluid pathway from the regulator housing to the diver to prevent fluids from flowing into the regulator housing through the mouthpiece. Saliva and exhaled air with its attendant moistures and pathogenic entities can thus be prevented from entering the regulator housing. The mouthpiece can be made easily detachable and can be sanitized between uses, making it particularly well suited for rental and instructional purposes. The disclosed invention keeps the interior spaces of the regulator clean and dry even when the regulator is not in place in the diver's mouth, thus extending regulator life and preventing a dangerous and irritating free-flow condition from occurring due to icing when used in cold water. The mouthpiece can be variously constructed to differentiate common-use mouthpieces from those owned individually.
摘要翻译： 提供了潜水员使用的第二级潜水调节器。 调节器包括调节器外壳和接口。 调节器壳体包括具有端口的吸入室和响应于通过端口的吸入而将空气释放到端口的需求阀。 吸嘴包括可连接到调节器壳体的单一壳体，并且包括单向呼气路径，从而避免了调节器壳体本身中的呼出路径的需要。 吸入式止回阀可以额外地结合到从调节器壳体到潜水员的流体通道中，以防止流体通过接口管流入调节器壳体。 因此可以防止唾液和呼出的空气及其伴随的湿润和致病实体进入调节器壳体。 喉舌可以很容易地拆卸，并且可以在使用之间进行消毒，使其特别适用于出租和教学目的。 所公开的发明保持调节器的内部空间即使在调节器不在潜水员的嘴中就位时也能够清洁和干燥，从而延长了调节器的使用寿命，并且防止在冷水中使用时由于结冰而产生危险和刺激性的自由流动状况 。 喉舌可以进行各种不同的构造，以将通用口气与单独使用的吸嘴区分开来。
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