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    BINDING AGENT
    11.
    发明申请
    BINDING AGENT 审中-公开
    绑定代理

    公开(公告)号：US20160194410A1

    公开(公告)日：2016-07-07

    申请号：US15079897

    申请日：2016-03-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Abstract translation: 式Aa'的结合剂：aSb：b'-B：X（n），其中A和B是一价结合剂，a：a以及b：b'是一个结合对，其中a' 并且a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示共价或通过结合对结合至至少一个“ ，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

    COMPOUND FOR SEQUENCING BY SYNTHESIS
    12.
    发明申请
    COMPOUND FOR SEQUENCING BY SYNTHESIS 有权
    通过合成测序的化合物

    公开(公告)号：US20150140561A1

    公开(公告)日：2015-05-21

    申请号：US14542980

    申请日：2014-11-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Frank Bergmann ,  Dieter Heindl ,  Jessica Steger-Domandl

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C07H19/10 ,  C07H19/20 ,  C12Q2525/186

    Abstract: The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.

    Abstract translation: 本发明提供了脱氧核苷三磷酸酯或四磷酸酯，其包含3'硝酸盐和可与氧原子共价结合的可检测标记，其中氧基甲氧基或氧杂环烷基或氧代炔基取代为核碱基。 这些化合物为将来通过Synthesis技术测序提供了新的可能性。

    Directed synthesis of oligophosphoramidate stereoisomers
    13.
    发明授权
    Directed synthesis of oligophosphoramidate stereoisomers 有权
    导向合成寡聚氨基磷酸酯立体异构体

    公开(公告)号：US08853132B2

    公开(公告)日：2014-10-07

    申请号：US14026936

    申请日：2013-09-13

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Dieter Heindl ,  Dirk Kessler ,  Angelika Roesler ,  Christoph Seidel ,  Wilma Thuer

    IPC: C07F9/6558 ,  G01N33/53 ,  C07F9/655

    CPC classification number: G01N33/5308 ,  C07F9/6552 ,  C07F9/65586 ,  Y02P20/55

    Abstract: The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.

    Abstract translation: 使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物或说明物。 具有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可切割的方式与固体支持物连接 接头。 在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。 这导致形成与叠氮化物反应的亚磷酸三酯。 通过选择具有定义的立体定构的合成合成单体，以立体控制的方式制备式1的化合物。

    METHOD FOR IMMUNOSENSING ON A LIPID LAYER USING MAGNETIC TUNNEL JUNCTIONS
    16.
    发明公开
    METHOD FOR IMMUNOSENSING ON A LIPID LAYER USING MAGNETIC TUNNEL JUNCTIONS 审中-公开

    公开(公告)号：US20240118271A1

    公开(公告)日：2024-04-11

    申请号：US18541875

    申请日：2023-12-15

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Regina Baranowski ,  Dieter Heindl ,  Nikolaus-Peter Stengele ,  Christian Wellner

    IPC: G01N33/543

    CPC classification number: G01N33/54326 ,  G01N2446/60

    Abstract: The present invention relates to diagnostic test and technology. In particular, the present invention relates to a method for determining an analyte suspected to be present in a sample comprising contacting said sample with a sensor element comprising an anchor layer which is present on a solid support, a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer and which comprises at least one magnetic label, wherein said at least one magnetic label is located within the anchor layer, a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, and a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the first binding agent, for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent and detecting the formation the complex of first binding agent, analyte and second binding agent based on the signal which is generated by the magnetic tunnel junction whereby the analyte is determined. Moreover, provided is a device for determining an analyte suspected to be present in a sample and the use thereof for determining an analyte suspected to be present in a sample in said sample. Moreover, the present invention contemplates a kit for determining an analyte suspected to be present in a sample.

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