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    Rotatable cartridge with multiple metering chambers
    11.
    发明授权
    Rotatable cartridge with multiple metering chambers 有权

    公开(公告)号：US10677809B2

    公开(公告)日：2020-06-09

    申请号：US15807802

    申请日：2017-11-09

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Thomas Keller

    IPC: G01N35/00 ,  G01N33/50 ,  B01L3/00 ,  G01F13/00 ,  G01N35/10

    Abstract: A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.

    Rotatable cartridge for processing and analyzing a biological sample
    12.
    发明授权
    Rotatable cartridge for processing and analyzing a biological sample 有权

    公开(公告)号：US10478817B2

    公开(公告)日：2019-11-19

    申请号：US15943093

    申请日：2018-04-02

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

    IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

    Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

    Cartridge with a rotatable lid
    13.
    发明授权
    Cartridge with a rotatable lid 有权

    公开(公告)号：US10086373B2

    公开(公告)日：2018-10-02

    申请号：US15352698

    申请日：2016-11-16

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke ,  Thorsten Brueckner

    IPC: B01L3/00 ,  G01N35/00 ,  G01N21/07 ,  G01N21/64 ,  G01N21/03

    Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.

    Sensor assembly
    18.
    发明授权
    Sensor assembly 有权

    公开(公告)号：US12163909B2

    公开(公告)日：2024-12-10

    申请号：US18326379

    申请日：2023-05-31

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Sascha Lutz ,  Gregor Ocvirk ,  Christoph Boehm ,  Wolfgang Burkhardt ,  Miriam Ruf ,  Heinz Kontschieder

    IPC: G01N27/06 ,  G01N33/487

    Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

    Measurement of an analyte with a cartridge
    19.
    发明授权
    Measurement of an analyte with a cartridge 有权

    公开(公告)号：US11369957B2

    公开(公告)日：2022-06-28

    申请号：US16116174

    申请日：2018-08-29

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

    IPC: B01L3/00 ,  B01J20/281 ,  G01N30/74

    Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

    SENSOR DEVICE AND METHOD OF USE
    20.
    发明申请
    SENSOR DEVICE AND METHOD OF USE 有权

    公开(公告)号：US20220196632A1

    公开(公告)日：2022-06-23

    申请号：US17643559

    申请日：2021-12-09

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Boehm ,  Miriam Ruf ,  Sascha Lutz ,  Heinz Kontschieder ,  Wolfgang Burkhardt ,  Gregor Ocvirk

    IPC: G01N33/487 ,  A61B5/1468 ,  A61B5/1455 ,  A61B5/053 ,  A61B5/1486

    Abstract: The present disclosure refers to a sensor device, a method of operating the sensor device and an IVD analyzer for receiving the sensor device for determining chemical and/or physical characteristics of a fluid. The sensor device comprises at least two fluidic conduits for repeatedly receiving fluids, each fluidic conduit comprising at least one sensory element arranged such as to come in contact with a fluid in the respective fluidic conduit. In particular, the fluidic conduits comprise different sensory elements, respectively, wherein the sensory elements are separated in the respective fluidic conduits according to compatibility or susceptibility to deterioration or operating temperature. Alternately, the fluidic conduits comprise at least in part the same sensory elements, wherein the sensor device is operated in a primary operating mode and in response to a trigger event, switches to an extended operating mode.

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