公开(公告)号：US20090118812A1

公开(公告)日：2009-05-07

申请号：US11934288

申请日：2007-11-02

Applicant: Jaydeep Y. Kokate ,  Raed Rizq ,  Jay Rassat ,  Derek Sutermeister ,  Samuel Robaina ,  Peter Edelman ,  Tom Holman ,  Michael Kuehling ,  Yixin Xu

Inventor： Jaydeep Y. Kokate ,  Raed Rizq ,  Jay Rassat ,  Derek Sutermeister ,  Samuel Robaina ,  Peter Edelman ,  Tom Holman ,  Michael Kuehling ,  Yixin Xu

IPC: A61F2/06

CPC classification number: A61L31/10 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  C23C14/06 ,  C23C14/3464

Abstract: A method includes: providing a substrate, depositing a ceramic and an extractable material onto the substrate, forming a porous structure in the ceramic by removing the extractable material, and utilizing the ceramic in an endoprosthesis. An endoprosthesis, such as a stent, including a coating formed of a ceramic and an extractable material that can be removed from the coating to form voids is also disclosed.

Abstract translation: 一种方法包括：提供衬底，将陶瓷和可提取材料沉积到衬底上，通过去除可提取材料在陶瓷中形成多孔结构，并在内置假体中利用陶瓷。 还公开了一种内置假体，例如支架，包括由陶瓷形成的涂层和可从涂层中除去以形成空隙的可提取材料。

公开(公告)号：US20070299505A1

公开(公告)日：2007-12-27

申请号：US11765679

申请日：2007-06-20

Applicant: Daniel Gregorich ,  Kevin Grotheim ,  Michael P. Meyer ,  Shawn Sorenson ,  Samuel Robaina

Inventor： Daniel Gregorich ,  Kevin Grotheim ,  Michael P. Meyer ,  Shawn Sorenson ,  Samuel Robaina

IPC: A61F2/06

CPC classification number: A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/005

Abstract: A bifurcated stent that uses turning segments to reduce the strain at regions which bend at extreme angles. The turning segments can be placed on side branch petals or on connectors connecting the petals to the stent body. Combining the turning segments with connectors of different length and tethers provides for a stent with high flexibility that can accommodate various shaped body vessels. This design allows the bifurcation branch to extend easily, to a useful distance, and to be deployed along oblique angles. Best of all, this design avoids the problems of angularly strained side branch.

Abstract translation: 一种分叉式支架，其使用转动节段来减小在极端角度弯曲的区域处的应变。 转动部分可以放置在侧分支花瓣上或将花瓣连接到支架主体上的连接器上。 将转动段与不同长度的连接器和系绳组合提供了具有高柔性的支架，其能够容纳各种成形的身体血管。 这种设计允许分叉分支容易地延伸到有用的距离，并且沿着倾斜的角度展开。 最重要的是，这种设计避免了角应变侧支的问题。

公开(公告)号：US20050129727A1

公开(公告)日：2005-06-16

申请号：US10768388

申请日：2004-01-30

Applicant: Jan Weber ,  Samuel Robaina

Inventor： Jan Weber ,  Samuel Robaina

IPC: A61F2/00 ,  A61K20060101 ,  A61K9/50 ,  A61K38/17 ,  A61K49/18 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61N1/00 ,  C12N9/99 ,  C12Q1/68

CPC classification number: B82Y5/00 ,  A61F2210/009 ,  A61K9/5094 ,  A61K47/6923 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/624 ,  Y10S977/81 ,  Y10S977/906

Abstract: Nanocapsules are disclosed which comprise (a) a drug-containing core and (b) a polyelectrolyte multilayer encapsulating the drug-containing core. The nanocapsules include particles whose largest dimension typically ranges between 50 nm to 10000 nm. In some embodiments, the nanocapsules contain a single drug. In others, the nanocapsules contain multiple drugs, either within the same nanocapsules or within separate populations of nanocapsules. In some embodiments, the nanocapsules comprise surfaces that are functionalized, for example, with ligands that allow for attachment to bodily tissue. In some embodiments of the present invention, the nanocapsules are rendered magnetic or are rendered susceptible to magnetic fields. Also disclosed is a drug delivery method that comprises the steps of (a) providing nanocapsules such as those above; and (b) placing the nanocapsules at a desired location within the body of a subject using an implantable or insertable medical device.

Abstract translation: 公开了纳米胶囊，其包含（a）含药物核心和（b）包封药物核心的聚电解质多层。 纳米胶囊包括最大尺寸通常在50nm至10000nm之间的颗粒。 在一些实施方案中，纳米胶囊含有单一药物。 在其他方面，纳米胶囊含有多种药物，无论是在相同的纳米胶囊内还是在分开的纳米胶囊内。 在一些实施方案中，纳米胶囊包含官能化的表面，例如具有允许附着于身体组织的配体。 在本发明的一些实施方案中，纳米胶囊被磁化或变得易受磁场影响。 还公开了药物递送方法，其包括以下步骤：（a）提供如上所述的纳米胶囊; 和（b）使用可植入或可插入的医疗装置将纳米胶囊放置在受试者体内的期望位置。

公开(公告)号：US09393136B2

公开(公告)日：2016-07-19

申请号：US13430907

申请日：2012-03-27

Applicant: Keith Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

Inventor： Keith Perkins ,  Samuel Robaina ,  Jeffery Argentine ,  Walter Bruszewski ,  Andrew Kiehl

IPC: A61F2/06 ,  A61F2/04 ,  A61F2/915 ,  A61F2/07 ,  A61F2/90 ,  A61F2/91 ,  A61F2/848

CPC classification number: A61F2/915 ,  A61F2/07 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2230/0013 ,  A61F2250/0018 ,  A61F2250/0029

Abstract: A variable zone high metal to vessel ratio stent includes a proximal high metal to vessel ratio zone, a central low metal to vessel ratio zone, and a distal high metal to vessel ratio zone. The proximal high metal to vessel ratio zone is deployed with fixation and sealing to healthy tissue of a main vessel superior to branch vessels and an aneurysm. The central low metal to vessel ratio zone is deployed directly on ostai of the branch vessels. However, as the central low metal to vessel ratio zone is highly permeable, blood flows from the main vessel through the central low metal to vessel ratio zone and into branch vessels.

Abstract translation: 可变区高金属与血管比例支架包括近端高金属与血管比例区域，中心低金属与血管比例区域和远端高金属与血管比例区域。 近端高金属与血管比例区域以固定和密封方式部署在主血管的优于分支血管和动脉瘤的健康组织上。 中心的低金属与血管比例区域直接部署在分支血管的Ostai上。 然而，由于中心的低金属与血管比例区域是高度可渗透的，血液从主血管通过中心的低金属到血管比例区域流入分支血管。

公开(公告)号：US08236044B2

公开(公告)日：2012-08-07

申请号：US11749855

申请日：2007-05-17

Applicant: Samuel Robaina

Inventor： Samuel Robaina

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0029

Abstract: A stent comprises at least one curve deployment section. The at least one curve deployment section comprises at least one expansion ring having a circumferential length, a longitudinal length and comprising a first circumferential section and a second circumferential section. The first circumferential section comprises an expansion column and the second circumferential section comprises at least two expansion columns longitudinally offset from one another. The expansion column of the first circumferential section is engaged to the at least two expansion columns of the second circumferential section.

Abstract translation: 支架包括至少一个曲线展开部分。 所述至少一个曲线展开部分包括至少一个具有圆周长度，纵向长度并包括第一圆周部分和第二圆周部分的膨胀环。 第一圆周部分包括膨胀柱，并且第二圆周部分包括彼此纵向偏移的至少两个膨胀塔。 第一周向部分的膨胀柱与第二圆周部分的至少两个膨胀柱接合。

公开(公告)号：US20110270378A1

公开(公告)日：2011-11-03

申请号：US12770536

申请日：2010-04-29

Applicant: Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

Inventor： Walter Bruszewski ,  Heath Muzslay ,  Emilie Johnson ,  Kevin Boyle ,  Mohammed Iftekhar ,  Samuel Robaina

IPC: A61F2/82

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2250/006

Abstract: An endovascular prosthesis includes a tubular body and a mobile external coupling. The tubular body includes a graft material and stents coupled thereto, a forms a lumen therethrough. The mobile external coupling extends outwardly from the tubular body. The mobile external coupling includes a graft material and is generally frustoconically shaped. The mobile external coupling includes a base coupled to the tubular body, a top spaced from the tubular body, and a coupling lumen disposed between the base and the top, wherein the coupling lumen is in flow communication with the body lumen. A cylindrical sealing cuff of graft material is attached to and extends from the top of the mobile external coupling towards the tubular body within the coupling lumen. The sealing cuff is configured to contact a portion of a branch vessel prosthesis and thereby provides an elongated interference seal between the branch vessel prosthesis and the mobile external coupling.

Abstract translation: 血管内假体包括管状主体和移动外部联接器。 管状体包括移植材料和与其连接的支架，a形成通过其中的腔。 移动外部联接件从管状体向外延伸。 移动外部联接件包括移植材料并且通常是截头圆锥形的。 移动外部联接器包括联接到管状体的基部，与管状体间隔开的顶部以及设置在基部和顶部之间的联接腔，其中联接腔与体腔流动连通。 移植材料的圆柱形密封套连接到移动外部联接器的顶部并且在联接腔内朝向管状体延伸。 密封套构造成接触分支血管假体的一部分，从而在分支血管假体和移动外部联接器之间提供细长的干涉密封。

公开(公告)号：US20110066227A1

公开(公告)日：2011-03-17

申请号：US12561781

申请日：2009-09-17

Applicant: Michael P. Meyer ,  Timothy S. Girton ,  Dennis Boismier ,  Daniel Gregorich ,  Kim Robertson ,  Liza Davis ,  Cory Hitzman ,  Samuel Robaina ,  Doug Thesingh

Inventor： Michael P. Meyer ,  Timothy S. Girton ,  Dennis Boismier ,  Daniel Gregorich ,  Kim Robertson ,  Liza Davis ,  Cory Hitzman ,  Samuel Robaina ,  Doug Thesingh

IPC: A61F2/06

CPC classification number: A61F2/915 ,  A61F2/90 ,  A61F2/91 ,  A61F2250/0035 ,  A61F2250/0068

Abstract: A stent having one or more beneficial agents which enhance the healing effect of the stent. The agent is positioned within a reservoir. The reservoir dynamically releases the agent when the stent is expanded. The reservoir makes use of various changes in stent shape during expansion to assure proper release of the agent. Agent release can be modulated at various points along the stent and with various rates of release. The reservoirs can also be cooperatively combined with features that enhance stent flexibility, structural integrity, and which prevent recoil.

Abstract translation: 具有增强支架愈合效果的一种或多种有益剂的支架。 试剂位于储存器内。 当支架扩张时，储层动态释放药剂。 储存器在膨胀期间利用支架形状的各种变化，以确保试剂的适当释放。 药剂释放可以在支架的各个点处以各种释放速率进行调节。 储存器还可以与增强支架柔性，结构完整性以及防止反冲的特征协同结合。

公开(公告)号：US20100023115A1

公开(公告)日：2010-01-28

申请号：US12178180

申请日：2008-07-23

Applicant: Samuel Robaina ,  Cory Hitzman ,  Kim Robertson ,  Liza Davis ,  Jason T. Lenz

Inventor： Samuel Robaina ,  Cory Hitzman ,  Kim Robertson ,  Liza Davis ,  Jason T. Lenz

IPC: A61F2/06

CPC classification number: A61F2/915 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0068

Abstract: A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.

Abstract translation: 用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。 至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。 所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。 每个井区域定义具有深度的井。 至少一些孔含有治疗剂。

公开(公告)号：US20090149942A1

公开(公告)日：2009-06-11

申请号：US12174752

申请日：2008-07-17

Applicant: Peter Edelman ,  Samuel Robaina

Inventor： Peter Edelman ,  Samuel Robaina

IPC: A61F2/06

CPC classification number: C08G65/3322 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  C08G65/33337 ,  C08L71/02 ,  C08L2203/02

Abstract: An endoprosthesis, e.g., a stent, that includes a pro-healing surface and a temporary non-fouling material attached to the surface, and a method of making the same are disclosed.

Abstract translation: 公开了一种内置假体，例如支架，其包括附着于表面的前恢复表面和临时非结垢材料及其制造方法。

公开(公告)号：US09284409B2

公开(公告)日：2016-03-15

申请号：US12174752

申请日：2008-07-17

Applicant: Peter Edelman ,  Samuel Robaina

Inventor： Peter Edelman ,  Samuel Robaina

IPC: A61F2/06 ,  C08G65/332 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  C08G65/333 ,  C08L71/02

CPC classification number: C08G65/3322 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  C08G65/33337 ,  C08L71/02 ,  C08L2203/02

Abstract: In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.

Abstract translation: 在实施例中，医疗装置具有包括催化材料的表面和附着在表面上的非结垢材料。 可以从表面释放非结垢材料，例如通过将材料连接到表面的键的断裂。 该键可以是化学键，例如共价键。