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11.发明授权Non-invasive sensor capable of determining optical parameters in a sample having multiple layers 有权能够确定具有多层的样品中的光学参数的非侵入式传感器公开(公告)号：US06353226B1
公开(公告)日：2002-03-05
申请号：US09198094
申请日：1998-11-23
申请人： Omar S. Khalil , Xiaomao Wu , Johannes Sake Kanger , Rene′ Alexander Bolt , Shu-Jen Yeh , Charles F. Hanna , Frits Frans Maria de Mul
发明人： Omar S. Khalil , Xiaomao Wu , Johannes Sake Kanger , Rene′ Alexander Bolt , Shu-Jen Yeh , Charles F. Hanna , Frits Frans Maria de Mul
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/49
摘要： Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e. g., stratum corneum and epidermis, in these determinations.
摘要翻译： 用于非侵入性地测量样品，特别是包括多个层的组织样品的至少一个光学参数的装置和方法。 可以使用至少一个参数来确定组织样品中感兴趣的分析物的存在或浓度。 本发明的装置和方法（1）测量从组织样本的较浅层基本反射，散射，吸收或发射的光，（2）测量基本上被反射，散射，吸收或发射的光 从组织样本的较深层，（3）确定这些层中的每一层的至少一个光学参数，以及（4）考虑较浅层对较深层的至少一个光学参数的影响。 指定采样深度允许确定组织样品（例如真皮）的特定层的光学性质，并减少来自其它层的干扰，例如， 在这些决定中，例如角质层和表皮。
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12.发明授权Method for the non-invasive determination of analytes in a selected volume of tissue 有权在选定体积的组织中非侵入性测定分析物的方法公开(公告)号：US06526298B1
公开(公告)日：2003-02-25
申请号：US09693122
申请日：2000-10-20
IPC分类号： A61B500
CPC分类号： A61B5/1495 , A61B5/0059 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , A61B5/6824 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/4795
摘要： A method for the determination of concentrations of analytes, e.g., glucose, and other metabolites in human tissue, wherein the temperature of a defined cutaneous volume of tissue, e.g., human skin, is controlled. The method involves calculating the concentration of an analyte in the tissue by taking into consideration the values of optical parameters of a sample of tissue measured in the defined cutaneous volume of the tissue at various temperatures. The selection of the defined volume is a function of the sampling distance along the surface of the tissue, the wavelength of light used to illuminate the tissue, and the temperature in the defined volume of tissue, which is a function of the temperature at the surface of the tissue. In one embodiment of the method of this invention, an optical signal re-emitted from a defined cutaneous volume of the tissue is measured, as the temperature of this volume is maintained at a constant value. In another embodiment of the method of this invention, the temperature of the defined cutaneous volume of the tissue is varied within a defined physiological range to change the depth of penetration of light into the tissue, thereby achieving a depth profile for the optical signal. The method of this invention is useful for monitoring the concentrations of analytes in tissues, testing at the point of care, and screening for diseases, such as, for example, diabetes. The method of this invention utilizes changes in temperature and selection of wavelengths to define cutaneous volumes below the surface of the tissue, in which volumes the concentration of an analyte can be determined.
摘要翻译： 用于测定人组织中分析物（例如葡萄糖）和其它代谢物的浓度的方法，其中控制例如人皮肤的组织的定义的皮肤体积的温度。 该方法包括通过考虑在各种温度下在组织的定义的皮肤体积中测量的组织样品的光学参数的值来计算组织中分析物的浓度。 定义体积的选择是沿着组织表面的采样距离，用于照亮组织的光的波长和组织的限定体积中的温度的函数，其是表面温度的函数 的组织。 在本发明的方法的一个实施例中，当该体积的温度保持在恒定值时，测量从组织的规定皮肤体积重新发射的光学信号。 在本发明方法的另一实施例中，组织的限定皮肤体积的温度在规定的生理范围内变化，以改变光进入组织的深度，从而实现光信号的深度分布。 本发明的方法可用于监测组织中分析物的浓度，在护理点进行测试和筛选疾病，例如糖尿病。 本发明的方法利用温度的变化和波长的选择来限定组织表面以下的皮肤体积，其中可以确定分析物的浓度。
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13.发明授权Method and apparatus for non-invasive measurement of living body characteristics by photoacoustics 有权通过光声学对生物体特征进行非侵入性测量的方法和装置公开(公告)号：US08326388B2
公开(公告)日：2012-12-04
申请号：US10532691
申请日：2003-10-28
IPC分类号： A61B5/1455
CPC分类号： A61B5/0095 , A61B5/14532 , A61B5/6843
摘要： A method and apparatus for non-invasive measurement of living body information comprises a light source configured to generate light containing a specific wavelength component, an irradiation unit configured to irradiate a subject with the light, and at least one acoustic signal detection unit including piezoelectric devices formed of a piezoelectric single crystal containing lead titanate and configured to detect an acoustic signal which is generated due to the energy of the irradiation light absorbed by a specific substance present in or on a subject.
摘要翻译： 一种生物体信息的非侵入式测量方法和装置，具备：生成包含特定波长成分的光的光源，被配置为对被检体照射的照射部，以及包含压电装置的至少一个声信号检测部 由包含钛酸铅的压电单晶形成，并且被配置为检测由于存在于被摄体中的特定物质吸收的照射光的能量而产生的声信号。
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公开(公告)号：US07254425B2
公开(公告)日：2007-08-07
申请号：US10763548
申请日：2004-01-23
申请人： Michael G. Lowery , Eric B. Shain , Omar S. Khalil
发明人： Michael G. Lowery , Eric B. Shain , Omar S. Khalil
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14535 , A61B5/7207 , G01N21/49
摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelengths, at different distances between the light introduction site(s) and the light collection site(s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.
摘要翻译： 一种用于识别通过使用温度控制的光学探针的装置测量生物样品中的分析物的浓度而发生的伪影的方法，将电磁辐射引入组织中，并且收集并检测距离该点 电磁辐射被引入。 收集在不同波长下，在光引入部位与光采集部位之间的不同距离以及不同温度下发射的辐射强度值，并用于该方法中以产生这些值与 组织中分析物的浓度或患者的疾病状态。 该方法涉及使用识别由患者运动产生的数据中的伪影的算法，并允许拒绝包含这些伪像的数据集。 该算法识别收集信号序列中的幅度和方向的突变。
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公开(公告)号：US5585242A
公开(公告)日：1996-12-17
申请号：US522623
申请日：1995-08-31
CPC分类号： G01N21/648 , B01L7/52 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/6428 , G01N2021/6484
摘要： An apparatus and method for detecting amplified target nucleic acid is provided wherein the presence and concentration of amplified target is determined by total internal reflection over the course of the amplification reaction. A method and apparatus for detecting target nucleic acid is also provided wherein the presence and concentration of target is determined by total internal reflection and coupling of the target to the TIR element by scissile linkage. An improved immunoassay using total internal reflection and differential temperature cycling is further provided.
摘要翻译： 提供了用于检测扩增的靶核酸的装置和方法，其中扩增的靶的存在和浓度由扩增反应过程中的全内反射决定。 还提供了用于检测靶核酸的方法和装置，其中靶的存在和浓度由全内反射确定，并通过剪切连接将靶标与TIR元件偶联。 进一步提供使用全内反射和差示温度循环的改进的免疫测定。
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公开(公告)号：US20120217385A1
公开(公告)日：2012-08-30
申请号：US13465408
申请日：2012-05-07
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译： 公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。 示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。 示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。 示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。 示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。
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公开(公告)号：US07858924B2
公开(公告)日：2010-12-28
申请号：US11637314
申请日：2006-12-12
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译： 用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。 每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口 腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。 周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。
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公开(公告)号：USD332834S
公开(公告)日：1993-01-26
申请号：US570565
申请日：1990-08-21
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公开(公告)号：US5089424A
公开(公告)日：1992-02-18
申请号：US425643
申请日：1989-10-23
申请人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
发明人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
IPC分类号： G01N21/76 , G01N33/52 , G01N33/543 , G01N33/576
CPC分类号： G01N33/54346 , G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/54386 , G01N33/5764
摘要： Apparatus and method for performing a chemiluminescence assay involving the immobilization of a chemiluminescent reaction complex to a solid, porous element. The solid, porous element is preferably treated to provide an immobilizing interaction with the chemiluminescent reaction complex wherein the chemiluminescent reaction complex is thereby immobilized to the solid, porous element. The activating and reading of the chemiluminescent reaction are separately performed by evenly distributing a concentrated chemiluminescent activating solution to form a puddle on the surface of the porous element to which the chemiluminescent reaction complex is immobilized.
摘要翻译： 用于进行化学发光测定的装置和方法，涉及将化学发光反应复合物固定在固体多孔元件上。 优选处理固体多孔元件以提供与化学发光反应复合物的固定相互作用，其中化学发光反应复合物由此固定在固体多孔元件上。 化学发光反应的激活和读取分别通过均匀分布浓缩的化学发光活化溶液在化学发光反应复合物固定的多孔元件的表面上形成一个水坑。
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公开(公告)号：US5006309A
公开(公告)日：1991-04-09
申请号：US184726
申请日：1988-04-22
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0809 , B01L2400/0406 , B01L2400/049 , Y10T436/255 , Y10T436/2575
摘要： A disposable device suitable for performing automated solid-state diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by an optical device. A device is disclosed having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well having (a) an entrance port and wash receiving structure for receiving a quantity of sample and assay reagents, (b) a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, the fibrous matrix positioned below the wash receiving structure, and having an average spatial separation of fibers greater than the average diameter of the microparticles and (c) a structure below the fibrous matrix for assisting the flow of sample and assay reagents through the fibrous matrix, such as an absorbent material or vacuum below the fibrous matrix and a passage means communicating between the shallow sample well and the read well where the sample and reaction mixtures can be transferred and washed from the shallow sample well into the read well without being contacted by any apparatus.
摘要翻译： 一种适用于执行自动化固态诊断测定的一次性装置，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得微粒上的分析物的存在可以通过光学装置检测。 公开了一种装置，其具有用于接收样品的浅样品阱和用于形成反应混合物的试剂，读数井具有（a）用于接收一定量的样品和测定试剂的入口和洗涤接收结构，（b）纤维 用于保持和固定用于检测的微粒/分析物复合物的基质，所述纤维基质位于洗涤接收结构下方，并且具有大于微粒平均直径的纤维的平均空间分离，和（c）纤维基质下面的结构用于辅助 通过纤维基质（例如吸收材料或纤维基质下方的真空）的样品和测定试剂的流动以及在浅样品阱和读数井之间连通的通道装置，其中样品和反应混合物可以从 浅样品很好地进入读取井，而不被任何装置接触。
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