公开(公告)号：US08569241B2

公开(公告)日：2013-10-29

申请号：US13532394

申请日：2012-06-25

申请人： Kazuhito Ohsawa ,  Naoto Uchida ,  Kohji Ohki ,  Hiroaki Goto

发明人： Kazuhito Ohsawa ,  Naoto Uchida ,  Kohji Ohki ,  Hiroaki Goto

IPC分类号： A01N37/18 ,  A61K38/00 ,  C07K16/00

CPC分类号： A61K38/04 ,  C07K7/08

摘要： Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.

摘要翻译： 提供了可以以低剂量口服摄取的用于改善脑功能的组合物及其方法。 用于改善脑功能的组合物含有作为活性成分的X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu- Y（其中X为零或表示Ile或Asn-Ile; Y为无或表示Val-Met），X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y X缺失或表示Thr-Gln-Thr-Pro，Pro-Leu-Thr-Gln-Thr-Pro，Leu-Thr-Gln-Thr-Pro或Pro; Y为缺失或代表Val-Met） 盐相同。 改善脑功能的方法包括施用所述肽或其相同的盐。

公开(公告)号：US08262677B2

公开(公告)日：2012-09-11

申请号：US12241131

申请日：2008-09-30

申请人： Hiroaki Goto

发明人： Hiroaki Goto

IPC分类号： A61B17/10

CPC分类号： A61B17/12013 ,  A61B1/00087 ,  A61B1/273 ,  A61B17/3478 ,  A61B2017/00292 ,  A61B2017/00296 ,  A61B2017/00367 ,  A61B2017/00535 ,  A61B2017/12018 ,  A61B2017/347

摘要： A ligation tool for endoscope includes an overtube having an insertion lumen 21a made of a flexible material, which permits an insertion portion 11 of the endoscope to be inserted therethrough so as to advance and retreat, an O-ring 22 for ligation attached to a distal end of the overtube, and a operation wire 24 which is locked to the O-ring for ligation, has a distal portion extending to the proximal side of the overtube, and is operated to be pulled or pushed at its proximal side, thereby separating the O-ring for ligation from the tip of the overtube. According to this ligation tool for endoscope, time and effort taken to set the ligation tool for endoscope in the endoscope becomes unnecessary, a sufficient field of vision of the endoscope can be secured, and the curving performance of the tip of the insertion portion of the endoscope does not deteriorate. Furthermore, this ligation tool is also advantageous when endoscopic sclerotherapy is performed together.

摘要翻译： 用于内窥镜的结扎工具包括具有由柔性材料制成的插入内腔21a的外套管，其允许内窥镜的插入部分11插入其中以便前后退;用于连接的远端O形环22， 外套管的端部和锁定到O形环用于结扎的操作线24具有延伸到外套管的近侧的远侧部分，并且被操作以在其近侧被拉动或推动，从而将 O形圈用于从外套管的尖端连接。 根据该内窥镜用连接工具，不需要在内窥镜中设置用于内窥镜的结扎工具所花费的时间和精力，能够确保内窥镜的足够的视野，并且，插入部的尖端的弯曲性能 内窥镜不会恶化。 此外，当一起进行内镜硬化治疗时，该连接工具也是有利的。

公开(公告)号：US20090177030A1

公开(公告)日：2009-07-09

申请号：US12323716

申请日：2008-11-26

申请人： Hiroaki Goto

发明人： Hiroaki Goto

IPC分类号： A61B1/00

CPC分类号： A61B17/32002 ,  A61B1/012 ,  A61B17/32056 ,  A61B18/1492 ,  A61B2017/00296 ,  A61B2017/320032 ,  A61B2018/00488 ,  A61B2018/00494 ,  A61B2018/1407 ,  A61B2018/144 ,  A61B2018/1495

摘要： An endoscopic incision system includes: an endoscope; a cylindrical member for covering at least a distal end of an insertion section of the endoscope; and at least an incision section for incising a living tissue, the incision section being provided to a distal end of the cylindrical member and being capable of being exposed from the distal end of the cylindrical member outwardly. In this configuration, the radially expanding incision section will not be twisted or bent, and the incision section prevented from inadvertent fall-off can maintain the desirable shape when it is operated and rotated.

摘要翻译： 内窥镜切割系统包括：内窥镜; 用于覆盖所述内窥镜的插入部的至少前端的筒状部件; 以及至少一个用于切割生物体组织的切口部分，所述切口部分设置在所述圆柱形部件的远端并且能够从所述圆柱形部件的远端向外露出。 在这种构造中，径向扩张的切口部分不会被扭曲或弯曲，并且防止切口部分无意中脱落时可以在操作和旋转时保持期望的形状。

公开(公告)号：US20090099414A1

公开(公告)日：2009-04-16

申请号：US12093706

申请日：2005-11-14

申请人： Hiroaki Goto ,  Masaru Yuasa ,  Kenichi Nishina ,  Tatsuya Saito

发明人： Hiroaki Goto ,  Masaru Yuasa ,  Kenichi Nishina ,  Tatsuya Saito

IPC分类号： A61B1/018 ,  A61B1/01

CPC分类号： A61B1/018 ,  A61B1/267 ,  A61B10/04 ,  A61B10/06 ,  A61B2010/0216 ,  A61B2017/347 ,  A61B2090/034 ,  A61B2090/062 ,  A61B2090/3784

摘要： A method of performing diagnosis or treatment perendoscopically in which a guide catheter is inserted inside a body, and the guide catheter is made to protrude beyond a distal end portion of the endoscope; and in which a first diagnosis or treatment is performed by inserting a medical treatment device that performs the diagnosis or treatment of the body inside the guide catheter, and causing this medical treatment device to protrude by a first predetermined distance from the guide catheter; and in which the medical treatment device is extracted from the guide catheter; and in which a second diagnosis or treatment is performed by inserting a medical treatment device into the guide catheter, and causing the medical treatment device to protrude by a second distance which is adjusted in accordance with the first predetermined distance.

摘要翻译： 一种执行诊断或治疗的方法，其中引导导管插入体内，导引导管突出超过内窥镜的远端部分; 并且其中通过将执行身体在导管内的诊断或治疗的医疗处理装置插入并使该医疗装置从导向导管突出第一预定距离来执行第一诊断或治疗; 并且其中所述医疗装置从所述导向导管拔出; 并且其中通过将医疗处理装置插入导管中进行第二诊断或治疗，并使医疗处理装置突出第二距离，第二距离是根据第一预定距离调节的。

公开(公告)号：US20080152915A1

公开(公告)日：2008-06-26

申请号：US12016228

申请日：2008-01-18

申请人： Takayuki Ishihara ,  Hiroaki Goto ,  Yoshihiro Ohta ,  Yuji Yamaguchi ,  Go Saito

发明人： Takayuki Ishihara ,  Hiroaki Goto ,  Yoshihiro Ohta ,  Yuji Yamaguchi ,  Go Saito

IPC分类号： B32B27/00 ,  C08F110/02

CPC分类号： C08L23/00 ,  C08J3/226 ,  C08J2323/08 ,  C08J2423/00 ,  C08L23/0815 ,  C08L2205/02 ,  Y10S525/902 ,  Y10T428/2998 ,  C08L2666/02 ,  C08L2666/06

摘要： A high-quality oxygen-absorbing resin composition which is obtained without suffering resin scorching. Also provided are pellets for the oxygen-absorbing resin composition which comprise a thermoplastic resin (A) and an oxidation catalyst. After the pellets are mixed with a trigger resin and a thermoplastic resin (C), the trigger resin functions as a trigger to cause the oxidation of the thermoplastic resins (A) and (C) to proceed. As a result, the resultant composition absorbs oxygen.

摘要翻译： 高品质的氧吸收树脂组合物，其不会发生树脂烧焦而得到。 还提供了包含热塑性树脂（A）和氧化催化剂的氧吸收性树脂组合物的粒料。 在颗粒与触发树脂和热塑性树脂（C）混合之后，触发树脂用作引发热塑性树脂（A）和（C）的氧化进行的触发剂。 结果，所得组合物吸收氧气。

公开(公告)号：US08809465B2

公开(公告)日：2014-08-19

申请号：US12527721

申请日：2008-02-14

申请人： Ikuo Komatsu ,  Yoshiko Narikawa ,  Yuji Yamaguchi ,  Hiroaki Goto

发明人： Ikuo Komatsu ,  Yoshiko Narikawa ,  Yuji Yamaguchi ,  Hiroaki Goto

IPC分类号： C08L23/04 ,  C08J3/20 ,  C08L23/08 ,  C08K5/098

CPC分类号： C08L23/04 ,  B29B9/12 ,  C08J3/12 ,  C08J3/201 ,  C08J2323/08 ,  C08K5/098 ,  C08K9/08 ,  C08L23/0815 ,  C08L2666/02

摘要： The present invention relates to resin pellets which comprises a thermoplastic resin (A) and an oxidation catalyst (B) which is not supported by any carrier, wherein if the peak area in the vicinity of 1715 cm−1 is defined to be Ic and the peak area observed in the vicinity of 1470 cm−1 is defined to be Im in the IR spectroscopic measurement of the pellets, the ratio: Ic/Im observed for the surface of the pellet is greater than that observed for the interior thereof. The pellets are thermoplastic resin pellets excellent in the oxygen-absorbing capacity and accordingly, they can suitably used as pellets for molding an oxygen absorptive resin article.

摘要翻译： 本发明涉及不含任何载体的热塑性树脂（A）和氧化催化剂（B）的树脂粒料，其中如果将1715cm -1附近的峰面积定义为Ic， 在1470cm -1附近观察到的峰面积在颗粒的IR光谱测定中被定义为Im，对于颗粒表面观察到的比例Ic / Im大于其内部观察到的比率。 颗粒是氧吸收能力优异的热塑性树脂颗粒，因此它们可以适合用作模塑氧吸收树脂制品的颗粒。

公开(公告)号：US08491463B2

公开(公告)日：2013-07-23

申请号：US12277508

申请日：2008-11-25

申请人： Hiroaki Goto

发明人： Hiroaki Goto

IPC分类号： A61B1/00

CPC分类号： A61B17/320725 ,  A61B1/00135 ,  A61B1/018 ,  A61B17/320758 ,  A61B18/1492 ,  A61B2017/00336 ,  A61B2017/0034 ,  A61B2017/00902

摘要： An endoscope treatment system includes: an endoscope; and a treatment tool that has a sheath that is inserted in a channel of an insertion portion of the endoscope, in which projection portions that project outward from the sheath in the radial direction are provided, and engagement portions that engage the projection portions are provided near the channel of the endoscope.

摘要翻译： 内窥镜处理系统包括：内窥镜; 以及处理工具，其具有插入在所述内窥镜的插入部的通道中的护套，所述护套设置有从所述护套向径向突出的突出部，并且与所述突出部接合的接合部靠近 内窥镜的通道。

公开(公告)号：US07862603B2

公开(公告)日：2011-01-04

申请号：US11875462

申请日：2007-10-19

申请人： Hiroaki Goto

发明人： Hiroaki Goto

IPC分类号： A61F2/06

CPC分类号： A61B1/3137 ,  A61F2/88 ,  A61F2/962 ,  A61F2002/9511 ,  A61F2250/0029 ,  A61F2250/0097 ,  A61M25/0138

摘要： A stent delivery system 1 for supplying a stent to a body cavity which includes an endoscope 6 that has an insertion portion 5 with a curvature portion 3 disposed at the distal end thereof, a sheath 7 that is disposed with the insertion portion 5 inserted in the inside thereof and a stent 2 placed on the outer surface of the distal end side thereof; and a regulating portion 8 that regulates the relative movement of the stent 2 to the proximal end side of the sheath 7, with the sheath 7 formed of a length that allows the distal end of the insertion portion 5 that is inserted in the sheath 7 to protrude from the distal end of the sheath 7. In accordance with the present invention, it is possible to provide a stent delivery system that can place a stent by endoscope observation without the need of excessive diametrical contraction or additional expansion of the stent.

摘要翻译： 一种用于向体腔供给支架的支架输送系统1，其包括内窥镜6，所述内窥镜6具有设置在其前端的具有曲率部3的插入部5，所述鞘7插入在所述插入部5中的插入部5中 其内侧设置有放置在其前端侧的外表面上的支架2; 以及调节部分8，其调节支架2相对于护套7的近端侧的相对移动，其中护套7形成为允许插入鞘7中的插入部分5的远端的长度 从护套7的远端突出。根据本发明，可以提供一种支架输送系统，其可以通过内窥镜观察放置支架，而不需要过度的直径收缩或支架的额外扩张。

公开(公告)号：US20100133468A1

公开(公告)日：2010-06-03

申请号：US12700829

申请日：2010-02-05

申请人： TAKAYUKI ISHIHARA ,  Hiroaki Goto ,  Yoshihiro Ohta ,  Yuji Yamaguchi ,  Go Saito

发明人： TAKAYUKI ISHIHARA ,  Hiroaki Goto ,  Yoshihiro Ohta ,  Yuji Yamaguchi ,  Go Saito

IPC分类号： C09K15/04

CPC分类号： C08L23/00 ,  C08J3/226 ,  C08J2323/08 ,  C08J2423/00 ,  C08L23/0815 ,  C08L2205/02 ,  Y10S525/902 ,  Y10T428/2998 ,  C08L2666/02 ,  C08L2666/06

摘要： A high-quality oxygen-absorbing resin composition which is obtained without suffering resin scorching. Also provided are pellets for the oxygen-absorbing resin composition which comprise a thermoplastic resin (A) and an oxidation catalyst. After the pellets are mixed with a trigger resin and a thermoplastic resin (C), the trigger resin functions as a trigger to cause the oxidation of the thermoplastic resins (A) and (C) to proceed. As a result, the resultant composition absorbs oxygen.

摘要翻译： 高品质的氧吸收树脂组合物，其不会发生树脂烧焦而得到。 还提供了包含热塑性树脂（A）和氧化催化剂的氧吸收性树脂组合物的粒料。 在颗粒与触发树脂和热塑性树脂（C）混合之后，触发树脂起到引发热塑性树脂（A）和（C）氧化的触发剂的作用。 结果，所得组合物吸收氧气。

公开(公告)号：US20070248834A1

公开(公告)日：2007-10-25

申请号：US11805352

申请日：2007-05-22

申请人： Takayuki Ishihara ,  Hiroaki Goto ,  Yoshihiro Ohta

发明人： Takayuki Ishihara ,  Hiroaki Goto ,  Yoshihiro Ohta

IPC分类号： B32B27/18 ,  C01B3/00 ,  C08F8/00

CPC分类号： B32B27/30 ,  B32B7/12 ,  B32B27/08 ,  B32B27/304 ,  B32B27/306 ,  B32B27/32 ,  B32B27/327 ,  B32B2250/24 ,  B32B2264/10 ,  B32B2270/00 ,  B32B2307/724 ,  B32B2307/7242 ,  B32B2439/70 ,  C08L23/04 ,  C08L23/0815 ,  C08L53/02 ,  C08L2205/02 ,  Y02E60/324 ,  Y10T428/25 ,  Y10T428/256 ,  Y10T428/257 ,  Y10T428/259 ,  Y10T428/31667 ,  Y10T428/31855 ,  Y10T428/31909 ,  C08L2666/06

摘要： The invention provides oxygen-absorbing resin compositions which are reduced in the quantity of by-product oxides and are excellent in oxygen-absorbing capacity, more specifically, an oxygen-absorbing resin composition which comprises a styrene resin, a thermoplastic resin having ethylene structure in the molecular structure, and a transition metal catalyst and in which the oxidation of the thermoplastic resin proceeds by the action of the styrene resin as a trigger to attain oxygen absorption, wherein the styrene resin comprises two kinds of styrene resins (A) and (B) different in styrene content and the styrene content of the resin (A) is higher than that of the resin (B); and an oxygen-absorbing resin composition comprising polyethylene, a resin other than polyethylene which is capable of acting as a trigger in the oxidation of polyethylene, and a transition metal catalyst, wherein the polyethylene comprises two or more kinds of polyethylenes and at least one of them is a linear low-density polyethylene obtained by copolymerizing ethylene with at least 4 wt % of a 1-alkene having 3 to 6 carbon atoms.

摘要翻译： 本发明提供氧化吸收树脂组合物，其减少副产物氧化物的量并且具有优异的吸氧能力，更具体地说，是一种吸氧树脂组合物，其包含苯乙烯树脂，具有乙烯结构的热塑性树脂 分子结构和过渡金属催化剂，其中热塑性树脂的氧化通过苯乙烯树脂作为触发剂的作用进行以获得氧吸收，其中苯乙烯树脂包括两种苯乙烯树脂（A）和（B ）苯乙烯含量不同，树脂（A）的苯乙烯含量高于树脂（B）的苯乙烯含量; 以及包含聚乙烯，聚乙烯以外的树脂，其能够用作聚乙烯氧化中的触发剂的氧吸收性树脂组合物和过渡金属催化剂，其中所述聚乙烯包含两种或更多种聚乙烯和至少一种 它们是通过使乙烯与至少4重量％的具有3至6个碳原子的1-烯烃共聚获得的线性低密度聚乙烯。