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    Brake control system
    11.
    发明授权
    Brake control system 有权
    制动控制系统

    公开(公告)号：US06212460B1

    公开(公告)日：2001-04-03

    申请号：US09230824

    申请日：1999-07-29

    申请人： Michael D Rizzo ,  Douglass L Carson ,  Stephen R Pastor ,  Ronald Paul ,  Duane E Bassett ,  Gordon L Tierney

    发明人： Michael D Rizzo ,  Douglass L Carson ,  Stephen R Pastor ,  Ronald Paul ,  Duane E Bassett ,  Gordon L Tierney

    IPC分类号： G06F770

    CPC分类号： B60T8/1755 ,  B60L3/0076 ,  B60L3/108 ,  B60L7/26 ,  B60L2240/16 ,  B60L2240/18 ,  B60L2240/22 ,  B60L2240/24 ,  B60L2240/461 ,  B60L2240/463 ,  B60L2240/465 ,  B60T2210/22

    摘要： In a vehicle with an active brake control system a control method comprising to the steps of: determining individual wheel speeds of the vehicle wheels responsive to sensor output signals (1016, 1018); determining a vehicle reference velocity responsive to the individual wheel speeds (1002-1012); measuring vehicle yaw rate (1128); determining a delta velocity for each wheel responsive to the individual wheel speed for the wheel and the vehicle reference velocity (326); and when the active brake control system is in the active state for at least one of the wheels, (a) setting a base delta velocity for the one wheel equal to the delta velocity for the one wheel immediately prior to the active brake control obtaining the active state for the one wheel (200); (b) determining a control term responsive to the measured vehicle yaw rate (806), wherein the control term represents a desired delta velocity for the one wheel; (c) setting a first target change in delta velocity responsive to the base delta velocity and the control term (204); and (d) controlling a first wheel brake for the one wheel so that a difference between the delta velocity for the one wheel and the desired delta velocity for the one wheel is minimized (208).

    摘要翻译： 在具有主动制动控制系统的车辆中，控制方法包括以下步骤：响应于传感器输出信号（1016,1018）确定车轮的各个车轮速度; 响应于各个车轮速度确定车辆参考速度（1002-1012）; 测量车辆偏航率（1128）; 响应于车轮的各个车轮速度和车辆参考速度确定每个车轮的增量速度（326）; 并且当主动制动控制系统对于至少一个车轮处于活动状态时，（a）在主动制动器控制之前立即将一个车轮的基准三角速度设置为等于一个车轮的三角速度获得 一轮（200）的活动状态; （b）确定响应于所测量的车辆横摆角速度（806）的控制项，其中所述控制项表示所述一个车轮所需的增量速度; （c）响应于所述基准三角洲速度和所述控制项（204），设定Δ速度的第一目标变化; 和（d）控制用于一个车轮的第一车轮制动器，使得一个车轮的三角速度与一个车轮的期望的三角速度之间的差最小化（208）。

    Method for a fully automated monoclonal antibody-based extended differential
    14.
    发明申请
    Method for a fully automated monoclonal antibody-based extended differential 有权
    全自动单克隆抗体扩增差异的方法

    公开(公告)号：US20050260766A1

    公开(公告)日：2005-11-24

    申请号：US11130492

    申请日：2005-05-17

    申请人： Ronald Paul ,  James Wyatt ,  Barbara Carrillo ,  Oilda Rubio ,  Diana Careaga ,  Lidice Lopez

    发明人： Ronald Paul ,  James Wyatt ,  Barbara Carrillo ,  Oilda Rubio ,  Diana Careaga ,  Lidice Lopez

    IPC分类号： G01N33/53 ,  G01N33/569

    CPC分类号： G01N33/56966 ,  G01N15/1459 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1402 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/13 ,  Y10T436/25125

    摘要： A method useful for the enumeration of cell populations in a biological sample includes the steps of reacting in a single reaction mixture a sample, a first antibody labeled with a fluorochrome having a first emission spectrum and an additional antibody. The first antibody binds to an antigenic determinant differentially expressed on leukocytes and non-leukocytes. The additional antibody binds to an antigenic determinant differentially expressed on mature and immature granulocytes or myeloid cells, and is labeled either with the first fluorochrome or an additional fluorochrome having an emission spectrum distinguishable from the first emission spectrum. The reaction mixture can be mixed with a nucleic acid dye having an emission spectrum that overlaps with one of the first or additional emission spectra. The reaction mixture may be treated with a lytic system that differentially lyses non-nucleated red blood cells and conserves leukocytes. Populations of hematological cells are detected and enumerated using at least two parameters (fluorescence, optical, and electrical) for each population.

    摘要翻译： 可用于计数生物样品中细胞群体的方法包括以下步骤：在单一反应混合物中使样品，用具有第一发射光谱的荧光染料标记的第一抗体和另外的抗体反应。 第一抗体结合在白细胞和非白细胞上差异表达的抗原决定簇。 另外的抗体结合在成熟和未成熟粒细胞或骨髓细胞上差异表达的抗原决定簇，并且用第一荧光染料或具有与第一发射光谱可区分的发射光谱的附加荧光染料进行标记。 反应混合物可以与具有与第一或另外的发射光谱之一重叠的发射光谱的核酸染料混合。 反应混合物可以用裂解体系来处理，所述裂解系统差异地裂解非成核红细胞并保存白细胞。 使用每个群体的至少两个参数（荧光，光学和电）检测和计数血细胞的群体。

    Method for screening cells or formed bodies for enumeration of populations expressing selected characteristics
    16.
    发明授权
    Method for screening cells or formed bodies for enumeration of populations expressing selected characteristics 失效
    用于筛选表达选定特征的群体的细胞或成形体的计数方法

    公开(公告)号：US5223398A

    公开(公告)日：1993-06-29

    申请号：US587646

    申请日：1990-09-20

    申请人： Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos Rodriguez ,  Thomas Russell ,  Ronald Paul

    发明人： Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos Rodriguez ,  Thomas Russell ,  Ronald Paul

    IPC分类号： G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00

    CPC分类号： G01N33/5094 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/56972 ,  G01N15/12 ,  G01N15/14 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1081 ,  G01N35/0098 ,  Y10S436/808

    摘要： A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected white blood cell population and/or subset thereof of a whole blood sample or portion thereof. A volume of a biological sample containing the white blood cells is prepared and at least one reactant specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed in one or more steps to obtain the desired white blood cell population analysis.The biological sample can be a whole blood sample and the reactant can include or be a lyse or a monoclonal antibody bound to microspheres, which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed for retrieving and analyzing the remaining blood cell population.

    摘要翻译： 一种用于自动并快速地检索，计数和/或分析全血样本或其部分的至少一个所选择的白细胞群体和/或其子集的方法和装置。 制备含有白细胞的体积的生物样品，并将至少一种特异性或优先选择的至少一些选定的生物细胞引入其中并在短时间内快速混合。 可以修改细胞的不透明度和/或体积参数，然后在一个或多个步骤中对混合物进行计数和分析以获得所需的白细胞群体分析。 生物样品可以是全血样品，并且反应物可以包括结合微球的裂解液或单克隆抗体，其将与特定细胞结合，或与结合抗体的溶血和微球体的组合。 微球可以是磁性的，并且结合的细胞可被磁性去除，用于检索和分析剩余的血细胞群体。

    Method for a fully automated monoclonal antibody-based extended differential
    18.
    发明申请
    Method for a fully automated monoclonal antibody-based extended differential 有权
    全自动单克隆抗体扩增差异的方法

    公开(公告)号：US20060269970A1

    公开(公告)日：2006-11-30

    申请号：US11475313

    申请日：2006-06-27

    申请人： Ronald Paul ,  Oilda Rubio ,  Diana Careaga ,  Lidice Lopez ,  Ravindra Mylvaganam

    发明人： Ronald Paul ,  Oilda Rubio ,  Diana Careaga ,  Lidice Lopez ,  Ravindra Mylvaganam

    IPC分类号： G01N33/567 ,  C07K16/46

    CPC分类号： G01N33/56966 ,  G01N15/1459 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1402 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/13 ,  Y10T436/25125

    摘要： Methods for differentially identifying cells in an instrument employ compositions containing a combination of selected antibodies and fluorescent dyes having different cellular distribution patterns and specificities, as well as antibodies and fluorescent dyes characterized by overlapping emission spectra which form non-compensatable spectral patterns. When utilizing the compositions described herein consisting of fluorescent dyes and fluorochrome labeled antibodies with overlapping spectra that cannot be separated or distinguished based upon optical or electronic compensation means, a new fluorescent footprint is established. This new fluorescent footprint is a result of the overlapping spectra and the combined cellular staining patterns of the dyes and fluorochrome labeled antibodies chosen for the composition. The new fluorescent footprint results in histogram patterns that are useful for the identification of additional cell populations or subtypes in hematological disease.

    摘要翻译： 用于差异鉴定仪器中的细胞的方法使用含有选择的抗体和具有不同细胞分布模式和特异性的荧光染料的组合的组合物，以及以形成不可补偿光谱图案的重叠发射光谱为特征的抗体和荧光染料。 当利用由本文描述的由荧光染料和荧光染料标记的抗体组成的组合物时，基于光学或电子补偿装置不能被分离或区分的重叠光谱，建立了新的荧光足迹。 这种新的荧光足迹是由组合物选择的染料和荧光染料标记的抗体的重叠光谱和组合的细胞染色模式的结果。 新的荧光足迹导致直方图模式，可用于鉴定血液疾病中的其他细胞群体或亚型。

    Brake control system
    19.
    发明授权
    Brake control system 失效
    制动控制系统

    公开(公告)号：US06325469B1

    公开(公告)日：2001-12-04

    申请号：US09230816

    申请日：1999-09-07

    申请人： Douglass L Carson ,  Ronald Paul ,  Michael D Rizzo ,  Stephen R Pastor ,  Duane E Bassett ,  Hsien H Chen ,  Yuen-Kwok Chin ,  Youssef A Ghoneim ,  Hong X Hu ,  Alan J Lee ,  William C Lin ,  Michael P Turski

    发明人： Douglass L Carson ,  Ronald Paul ,  Michael D Rizzo ,  Stephen R Pastor ,  Duane E Bassett ,  Hsien H Chen ,  Yuen-Kwok Chin ,  Youssef A Ghoneim ,  Hong X Hu ,  Alan J Lee ,  William C Lin ,  Michael P Turski

    IPC分类号： B60T824

    CPC分类号： B60T8/1755

    摘要： A brake system control for use in a vehicle with four wheels comprising the steps of: determining a desired yaw rate (454); determining a yaw torque command responsive to the desired yaw rate (806); if the vehicle is in an anti-lock braking mode during driver commanded braking, applying the yaw torque command to only one of the four wheels to release brake pressure in said one of the four wheels (258-266, 274, 278, 280, 410-418); if the vehicle is in a positive acceleration traction control mode during driver commanded acceleration, applying the yaw torque command to only one of the four wheels to apply brake pressure in said one of the four wheels (258-266, 288-292, 410-418); and if the vehicle is not in the anti-lock braking mode or in the positive acceleration traction control mode, then: (i) determining whether a vehicle brake pedal is depressed (370); (ii) if the vehicle brake pedal is depressed, applying brake force to the vehicle wheels responsive to the depression of the brake pedal (374, 412, 418), wherein the applied brake force is modified to at least two of the vehicle wheels to create a left-right brake torque differential responsive to the yaw torque command.

    摘要翻译： 一种用于具有四个车轮的车辆的制动系统控制器，包括以下步骤：确定期望的偏航率（454）; 响应于所需的偏航率（806）确定偏航扭矩指令; 如果车辆在驾驶员指令制动期间处于防抱死制动模式，则将偏航转矩指令应用于四个车轮中的一个车轮，以释放所述四个车轮（258-266,274,278,280,280）中的一个车轮中的制动压力， 410-418）; 如果车辆在驾驶员指令加速期间处于正加速牵引力控制模式，则将偏航转矩指令仅施加到四个车轮中的一个车轮上，以将四个车轮（258-266,288-292,410- 418）; 并且如果车辆不处于防抱死制动模式或正加速牵引力控制模式，则：（i）确定车辆制动踏板是否被压下（370）; （ii）如果所述车辆制动踏板被压下，则响应于所述制动踏板（374,412,418）的下压而向所述车辆车轮施加制动力，其中所施加的制动力被修改为所述车辆车轮中的至少两个， 响应于偏航扭矩命令产生左右制动扭矩差。

    Active brake balance control method
    20.
    发明授权
    Active brake balance control method 有权
    主动制动平衡控制方法

    公开(公告)号：US06179394B2

    公开(公告)日：2001-01-30

    申请号：US09188137

    申请日：1998-11-09

    申请人： Edmund S. Browalski ,  Stephen R. Pastor ,  Ronald Paul

    发明人： Edmund S. Browalski ,  Stephen R. Pastor ,  Ronald Paul

    IPC分类号： B60T860

    CPC分类号： B60T8/1755 ,  B60G17/019 ,  B60G17/0195 ,  B60G2400/0511 ,  B60G2400/0521 ,  B60G2400/0523 ,  B60G2400/104 ,  B60G2400/208 ,  B60G2400/252 ,  B60G2400/39 ,  B60G2400/412 ,  B60G2800/016 ,  B60G2800/16 ,  B60G2800/21 ,  B60G2800/215 ,  B60G2800/22 ,  B60G2800/702 ,  B60G2800/91 ,  B60G2800/92 ,  B60G2800/922

    摘要： An improved control method that utilizes active brake controls to provide vehicle control during conditions of carriage motion tendency about a longitudinal vehicle axis. Accordingly, the control may be integrated with known active brake controls that regulate yaw rate and/or slip angle or traction controls that regulate front wheel slippage, thereby significantly improving the functionality of the respective control for little or no additional cost. A measure of vehicle carriage motion tendency is determined by computing a control parameter based on the roll angle of the vehicle and the rate of change of roll angle. If the computed control parameter exceeds a first calibrated threshold, a condition of carriage motion tendency is detected and the active brake control actuators are activated to reduce the velocity of the front wheels of the vehicle by a delta velocity command determined as a function of the roll angle and roll angle rate. When the computed control parameter falls below a second calibrated threshold, the delta velocity command is gradually decayed to exit the control.

    摘要翻译： 一种改进的控制方法，其利用主动制动控制来在关于纵向车辆轴线的滑架运动趋势的条件下提供车辆控制。 因此，控制可以与调节偏转速度和/或滑移角的已知主动制动控制器或调节前轮打滑的牵引力控制器相结合，由此极少地或不需要额外的成本来显着改善相应控制器的功能。 通过基于车辆的侧倾角和滚动角的变化率来计算控制参数来确定车辆滑架运动趋势的度量。 如果所计算的控制参数超过第一校准阈值，则检测到滑架运动趋势的状态，并且激活主动制动控制致动器以通过根据滚动来确定的增量速度命令来降低车辆前轮的速度 角度和角度角度。 当计算出的控制参数低于第二校准阈值时，增量速度命令逐渐衰减以退出控制。