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公开(公告)号：US06953667B2
公开(公告)日：2005-10-11
申请号：US10054988
申请日：2002-01-25
申请人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
发明人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/02 , A61P25/12 , A61P25/16 , A61P25/18 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , C07K16/22 , C07K17/02 , C12N9/96
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20080146505A1
公开(公告)日：2008-06-19
申请号：US11832009
申请日：2007-08-01
申请人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
发明人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
IPC分类号： A61K38/16 , C07H21/00 , C12N15/63 , C12N5/00 , A61K31/7052 , C07K14/00 , C12P21/00 , G01N33/68 , C07K16/00 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06566325B2
公开(公告)日：2003-05-20
申请号：US09904615
申请日：2001-07-16
申请人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
发明人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
IPC分类号： C07K1400
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US06475753B1
公开(公告)日：2002-11-05
申请号：US09461325
申请日：1999-12-14
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C12P2102
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06627741B2
公开(公告)日：2003-09-30
申请号：US10012542
申请日：2001-12-12
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C07K1624
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06605592B2
公开(公告)日：2003-08-12
申请号：US09800729
申请日：2001-03-08
申请人： Jian Ni , Kevin P. Baker , Charles E. Birse , Reinhard Ebner , Michele Fiscella , George A. Komatsoulis , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Ping Wei , Kimberly A. Florence
发明人： Jian Ni , Kevin P. Baker , Charles E. Birse , Reinhard Ebner , Michele Fiscella , George A. Komatsoulis , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Ping Wei , Kimberly A. Florence
IPC分类号： C07K1447
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application relates to a novel human protein, Protein HOFNF53. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 特别地，本申请涉及新的人蛋白质蛋白质HOFNF53。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090253626A1
公开(公告)日：2009-10-08
申请号：US12325800
申请日：2008-12-01
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N5/00 , G01N33/53 , C07K14/435 , C07K16/00 , C12P21/06
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US07459531B2
公开(公告)日：2008-12-02
申请号：US11565909
申请日：2006-12-01
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： C07K14/47
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090305991A1
公开(公告)日：2009-12-10
申请号：US12538668
申请日：2009-08-10
申请人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
发明人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
IPC分类号： A61K38/16 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12N1/21 , C07K14/435 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/02 , G01N33/566
摘要： The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及33种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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