公开(公告)号：US06974456B2

公开(公告)日：2005-12-13

申请号：US10156505

申请日：2002-05-28

Applicant: Stuart D. Edwards ,  John W. Gaiser ,  David S Utley

Inventor： Stuart D. Edwards ,  John W. Gaiser ,  David S Utley

IPC: A61B18/00 ,  A61B17/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61N1/06 ,  A61B18/18

CPC classification number: A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00039 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00142 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00982 ,  A61B2018/0237 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2090/064 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06

Abstract: The present invention comprises a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity.In another embodiment of the method of the invention, a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. The sphincter, lower esophageal sphincter, stomach, cardia or fundus is stimulated to produce a transient relaxation of the sphincter. The portion of the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing a relaxation of the sphincter is indentified. Energy is delivered from the sphincter electropotential mapping device to treat the portion the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing the transient relaxation of the sphincter.

Abstract translation: 本发明包括一种治疗括约肌的方法，所述括约肌具有至少一个映射电极或治疗电极提供括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。 在本发明方法的另一个实施方案中，一种治疗括约肌的方法，所述括约肌提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 括约肌，食管下括约肌，胃，贲门或眼底被刺激以产生括约肌的短暂松弛。 括约肌部分，食管下括约肌，胃，贲门或眼底引起松弛的括约肌是确定的。 能量从括约肌电位测绘装置输送到治疗括约肌，下食道括约肌，胃，贲门或眼底的部分，导致括约肌的暂时松弛。

公开(公告)号：US06716196B2

公开(公告)日：2004-04-06

申请号：US09797483

申请日：2001-02-28

Applicant: Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

Inventor： Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

IPC: A61M5178

CPC classification number: A61M25/0136 ,  A61B17/22 ,  A61B2017/00243 ,  A61B2017/22082 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3784 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61N7/02

Abstract: This is a method and an apparatus for the introduction of therapeutic compounds into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected therapeutic compound to be delivered to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.

Abstract translation: 这是用于将治疗化合物引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许将所选择的治疗化合物递送到特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。

公开(公告)号：US06569159B1

公开(公告)日：2003-05-27

申请号：US09513727

申请日：2000-02-24

Applicant: Stuart D. Edwards ,  James Baker ,  Hugh Sharkey ,  Ronald G. Lax

Inventor： Stuart D. Edwards ,  James Baker ,  Hugh Sharkey ,  Ronald G. Lax

IPC: A61B1818

CPC classification number: A61B18/1477 ,  A61B18/1206 ,  A61B18/14 ,  A61B18/1402 ,  A61B18/1482 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00196 ,  A61B2018/00273 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1435 ,  A61B2018/1472 ,  A61B2018/162 ,  A61B2018/1861 ,  A61B2218/002 ,  A61M1/0084 ,  A61M3/0279 ,  A61M25/007 ,  A61N1/403 ,  A61N5/02 ,  A61N5/04 ,  A61N5/045 ,  B22F2999/00 ,  C22C1/0491 ,  C22C14/00 ,  C22F1/183 ,  B22F3/1216 ,  C22C33/0285

Abstract: A cell necrosis apparatus comprises an elongated delivery device including a lumen and an energy delivery device. The energy delivery device includes at least a first and a second RF electrode each with a tissue piercing distal portion. The first and second RF electrodes are positionable in the elongated delivery device in a compacted state and deployable from the elongated delivery device with curvature in a deployed state. The first and second RF electrodes exhibit a changing direction of travel when advanced from the elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the elongated delivery device, the energy delivery device, the first RF electrode or the second RF electrode.

Abstract translation: 细胞坏死装置包括细长递送装置，其包括内腔和能量输送装置。 能量输送装置至少包括第一和第二RF电极，每个具有组织刺穿的远端部分。 第一和第二RF电极可以处于致密状态的细长输送装置中定位，并且可以从处于展开状态的曲率的细长输送装置展开。 第一和第二RF电极在从细长递送装置前进到选定的组织部位时表现出改变的行进方向。 至少一个输注端口连接到细长输送装置，能量输送装置，第一RF电极或第二RF电极之一。

公开(公告)号：US06517535B2

公开(公告)日：2003-02-11

申请号：US09437306

申请日：1999-11-09

Applicant: Stuart D. Edwards

Inventor： Stuart D. Edwards

IPC: A61B1818

CPC classification number: A61B18/1485 ,  A61B18/1477 ,  A61B18/148 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/4216 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1472 ,  A61B2218/002 ,  A61M3/0279 ,  A61M16/0481 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61N1/06 ,  A61N1/08 ,  A61N5/04

Abstract: An apparatus is provided for ablating at least a portion of a nasal concha. By ablating at least a portion of a nasal concha, the size of the nasal concha is reduced. The three nasal concha in the body (inferior, middle and superior nasal concha) form at least a portion of the three nasal meatus (inferior, middle and superior nasal meatus) in the body. By reducing the size of a nasal concha, obstruction of a nasal meatus is reduced or eliminated. As a result, air flow through the nasal meatus is improved. In one embodiment, the apparatus includes a catheter having a distal portion with a dimension configured for positioning the catheter distal portion through a nostril of a patient into a nasal meatus at a surface of a nasal concha, an expandable member positioned adjacent the catheter distal portion, an energy delivery device for delivering ablative energy positioned adjacent the catheter distal portion, and a lumen coupled to the catheter for delivering a medium into the expandable member to expand the expandable member.

Abstract translation: 提供了一种用于烧蚀鼻内耳的至少一部分的装置。 通过消融至少一部分鼻内耳，鼻内耳的尺寸减小。 身体中的三个鼻甲（下鼻甲，中鼻和上鼻）形成体内三个鼻腔（下，中，上鼻孔）的至少一部分。 通过减小鼻塞的尺寸，可减少或消除鼻塞的阻塞。 结果，改善了通过鼻腔的气流。 在一个实施例中，该装置包括导管，该导管具有远端部分，该远端部分具有被配置用于将导管远端部分定位穿过患者鼻孔进入鼻塞表面的鼻腔，位于邻近导管远端部分的可扩张部件 用于传送邻近导管远端部分定位的消融能量的能量递送装置，以及联接到导管的腔，用于将介质输送到可扩张构件中以使可扩张构件膨胀。

公开(公告)号：US06470219B1

公开(公告)日：2002-10-22

申请号：US09678500

申请日：2000-10-02

Applicant: Stuart D. Edwards ,  Peter Edelstein ,  Hong Li

Inventor： Stuart D. Edwards ,  Peter Edelstein ,  Hong Li

IPC: A61B1818

CPC classification number: A61B18/1477 ,  A61B18/1485 ,  A61B2018/00029 ,  A61B2018/00285 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00916 ,  A61B2218/007 ,  A61N1/0524 ,  A61N1/06 ,  A61N1/36007

Abstract: Apparatus for remodeling in the urinary tract of a human female comprising a remodeling device having a shaft with a profile and with proximal and distal extremities. A handle is secured to the proximal extremity of the shaft. A member is mounted on the distal extremity of the shaft. A plurality of needle electrodes are carried by the distal extremity of the shaft and are disposed circumferentially of the shaft. A pusher is carried by the handle for moving the needle electrodes from a retracted position in which they are within the profile of the shaft and an extended position in which they extend sidewise beyond the profile of the shaft. A pump is connected to the handle for supplying a cooling liquid to the distal extremity of the shaft so that it exits from the shaft in the vicinity of the needle electrodes. An RF generator is coupled to the handle and to the needle electrodes for supplying radio frequency energy to the needle electrodes.

Abstract translation: 用于在人类女性的尿道中重塑的装置，包括具有轮廓和具有近端和远端四肢的轴的重塑装置。 手柄固定到轴的近端。 一个构件安装在轴的远端上。 多个针电极由轴的远端承载并且设置在轴的周向。 推动器由手柄承载，用于使针电极从其在轴的轮廓内的缩回位置移动并且延伸位置，在该延伸位置中它们侧向延伸超过轴的轮廓。 泵连接到手柄，用于将冷却液供给到轴的远端，使得其在针电极附近从轴离开。 RF发生器耦合到手柄和针电极，用于向针电极提供射频能量。

公开(公告)号：US06179803B2

公开(公告)日：2001-01-30

申请号：US09085741

申请日：1998-05-28

Applicant: Stuart D. Edwards ,  Ronald G. Lax

Inventor： Stuart D. Edwards ,  Ronald G. Lax

IPC: A61B1720

CPC classification number: A61N5/045 ,  A61B17/24 ,  A61B18/1206 ,  A61B18/1402 ,  A61B18/1442 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/22 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00296 ,  A61B2017/248 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00101 ,  A61B2018/00196 ,  A61B2018/00291 ,  A61B2018/00327 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00744 ,  A61B2018/00773 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00982 ,  A61B2018/1425 ,  A61B2090/3782 ,  A61B2218/003 ,  A61M2025/0096 ,  A61N1/06 ,  A61N1/403 ,  A61N5/04

Abstract: An apparatus that reduces a volume of a selected site in an interior of the tongue includes a handpiece means and an electrode means at least partially positioned in the interior of the handpiece means. The electrode means includes an electrode means electromagnetic energy delivery surface and is advance able from the interior of the handpiece means into the interior of the tongue. An electrode means advancement member is coupled to the electrode means and configured to advance the electrode means an advancement distance in the interior of the tongue. The advancement distance is sufficient for the electrode means electromagnetic energy delivery surface to deliver electromagnetic energy to the selected tissue site and reduce a volume of the selected site without damaging a hypoglossal nerve. A cable means is coupled to the electrode means.

Abstract translation: 减少舌头内部的选定部位的体积的装置包括手柄装置和至少部分地定位在手持件装置内部的电极装置。 电极装置包括电极装置电磁能量输送表面，并且能够从手持件的内部进入舌头的内部。 电极装置前进构件联接到电极装置并且被配置为使电极装置前进到舌头内部的前进距离。 前进距离足以使电极意味着电磁能量传递表面将电磁能量传递到所选择的组织部位，并减少所选择的部位的体积而不损伤舌下神经。 电缆装置连接到电极装置。

公开(公告)号：US6152143A

公开(公告)日：2000-11-28

申请号：US55133

申请日：1998-04-03

Applicant: Stuart D. Edwards

Inventor： Stuart D. Edwards

IPC: A61B17/00 ,  A61B18/14 ,  A61B18/18 ,  A61N1/06 ,  A61N5/04 ,  A61B19/00

CPC classification number: A61N5/045 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61N1/06 ,  A61B2017/00026 ,  A61B2018/00291 ,  A61B2018/00327 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00875 ,  A61B2090/3782 ,  A61B2218/003

Abstract: A method for reducing a volume of a tongue includes providing an ablation apparatus with an energy delivery device configured to be coupled to an energy source. The energy delivery device is positioned in an interior of the tongue. A sufficient amount of energy is delivered from the energy delivery device in the interior of the tongue to ablate a section of the tongue without damaging the main branches of the hypoglossal nerve. The energy delivery device is thereafter removed from the interior of the tongue.

Abstract translation: 一种用于减小舌头体积的方法包括：提供消融装置，该消融装置配置成耦合到能量源上的能量输送装置。 能量输送装置位于舌头的内部。 足够量的能量从舌头内部的能量输送装置输送以烧蚀舌头的一部分而不损伤舌下神经的主要分支。 之后将能量输送装置从舌头的内部移除。

公开(公告)号：US6110196A

公开(公告)日：2000-08-29

申请号：US98596

申请日：1998-06-17

Applicant: Stuart D. Edwards

Inventor： Stuart D. Edwards

IPC: A61B18/14 ,  A61F7/00

CPC classification number: A61B18/14 ,  A61B2018/1407

Abstract: Apparatus for being held by the human hand for treating the tympanic membrane in an ear by the use of electromagnetic energy. An elongate probe has proximal and distal extremities. The proximal extremity is sized to be grasped by a human hand and the elongate probe has a length so that the distal extremity can be held in close proximity to the tympanic membrane while the proximal extremity is being held by the human hand. An energy delivery member is carried by the distal extremity. Conductors carried by the elongate probe conduct electromagnetic energy to the energy delivery member. A dispersive member is carried by the energy delivery member for dispersing the electromagnetic energy from the energy delivery member and applies energy to the tympanic membrane to heat the tympanic membrane in order to cause shrinkage of the tympanic membrane.

Abstract translation: 用于通过使用电磁能量来手持用于治疗耳朵中的鼓膜的装置。 细长的探针具有近端和远端。 近端末端的尺寸被人的手抓住，并且细长的探针具有一长度，使得远端可以靠近鼓膜保持，而近端被人的手握住。 能量传递构件由远端承载。 由细长探针携带的导体将电磁能量传导到能量输送构件。 分散构件由能量输送构件承载，用于分散来自能量输送构件的电磁能，并将能量施加到鼓膜以加热鼓膜，以引起鼓膜收缩。

公开(公告)号：US6092528A

公开(公告)日：2000-07-25

申请号：US36091

申请日：1998-03-06

Applicant: Stuart D. Edwards

Inventor： Stuart D. Edwards

IPC: A61B17/00 ,  A61B17/22 ,  A61B17/42 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61F2/958 ,  A61F7/12 ,  A61M3/02 ,  A61M16/04 ,  A61N1/05 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40 ,  A61B19/00

CPC classification number: A61B18/00 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/148 ,  A61B18/1485 ,  A61B18/1492 ,  A61M16/0481 ,  A61N1/056 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22062 ,  A61B2017/22072 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00738 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/0262 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61F7/12 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61M25/1002 ,  A61M3/0279 ,  C08L2201/12

Abstract: A method of treating a sphincter provides a treatment apparatus that includes an expandable device coupled to an introducer distal portion and an energy delivery device. The expandable device includes a first arm and a second arm each with proximal and distal section. The expandable member has a non-deployed configuration and a deployed configuration when the first and second arm distend away from each other. The expandable device is at least partially introduced in the sphincter. At least a portion of the energy delivery device is advanced from the expandable device into an interior of the sphincter. Sufficient energy is delivered from the energy delivery device to create a desired tissue effect in the sphincter. The expandable device is then removed from the sphincter.

Abstract translation: 治疗括约肌的方法提供了一种治疗装置，其包括联接到导引器远端部分和能量输送装置的可扩张装置。 可扩张装置包括第一臂和第二臂，每个臂具有近侧和远端部分。 当第一臂和第二臂彼此远离时，可扩张构件具有非展开构造和展开构型。 可扩张装置至少部分地引入括约肌。 能量输送装置的至少一部分从可扩张装置前进到括约肌的内部。 从能量输送装置输送足够的能量以在括约肌中产生期望的组织效应。 然后将可扩张装置从括约肌中取出。

公开(公告)号：US6077257A

公开(公告)日：2000-06-20

申请号：US717612

申请日：1996-09-20

Applicant: Stuart D. Edwards ,  Steven Marcus

Inventor： Stuart D. Edwards ,  Steven Marcus

IPC: A61B17/00 ,  A61B17/22 ,  A61B17/24 ,  A61B17/30 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B18/22 ,  A61B19/00 ,  A61F2/82 ,  A61M1/00 ,  A61M25/00 ,  A61N1/06 ,  A61N1/40 ,  A61N5/04 ,  A61M31/00

CPC classification number: A61B18/1485 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61F2/82 ,  A61N1/06 ,  A61N1/403 ,  A61N5/045 ,  A61B17/24 ,  A61B18/1402 ,  A61B18/1442 ,  A61B18/20 ,  A61B18/22 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00296 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/306 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00101 ,  A61B2018/00196 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00327 ,  A61B2018/0041 ,  A61B2018/00416 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00773 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00982 ,  A61B2018/1425 ,  A61B2090/3614 ,  A61B2218/003 ,  A61B90/361 ,  A61M2025/0096

Abstract: The invention provides an apparatus and system for ablation of body structures or tissue in the region of the rectum. A catheter is inserted into the rectum, and an electrode is disposed thereon for emitting energy. The environment for an ablation region is isolated or otherwise controlled by blocking gas or fluid using a pair of inflatable balloons at upstream and downstream locations. Inflatable balloons also serve to anchor the catheter in place. A plurality of electrodes are disposed on the catheter and at least one such electrode is selected and advanced out of the catheter to penetrate and ablate selected tissue inside the body in the region of the rectum. The electrodes are coupled to sensors to determine control parameters of the body structure or tissue, and which are used by feedback technique to control delivery of energy for ablation or fluids for cooling or hydration. The catheter includes an optical path disposed for coupling to an external view piece, so as to allow medical personnel to view or control positioning of the catheter and operation of the electrodes. The catheter is disposed to deliver flowable substances for aiding in ablation, or for aiding in repair of tissue, such as collagen or another substance for covering lesions or for filling fissures. The flowable substances are delivered using at least one lumen in the catheter, either from at least one hole in the catheter, from an area of the catheter covered by a microporous membrane, or from microporous balloons.