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公开(公告)号：US11957910B2
公开(公告)日：2024-04-16
申请号：US17473406
申请日：2021-09-13
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
CPC分类号： A61N1/36103 , A61H1/0237 , A61H1/0274 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36003 , A63B21/00181 , A61N1/3616 , A63B22/0235 , A63B69/0064 , A63B2213/004 , A63B2220/805 , A63B2230/60 , F04C2270/0421
摘要： Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.
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公开(公告)号：US20180229038A1
公开(公告)日：2018-08-16
申请号：US15940473
申请日：2018-03-29
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, JR. , Yangsheng Chen
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/11 , A61B5/0492
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
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公开(公告)号：US20170157389A1
公开(公告)日：2017-06-08
申请号：US15232623
申请日：2016-08-09
申请人： California Institute of Technology , The Regents of the University Of California , University of Louisville Research Foundation, Inc.
发明人： Yu-Chong Tai , Mandheerej S. Nandra , Joel W. Burdick , Damien Craig Rodger , Andy Fong , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Igor Lavrov , Susan J. Harkema , Claudia A. Angeli
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0558
摘要： An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.
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14.发明申请公开(公告)号：US20140316503A1
公开(公告)日：2014-10-23
申请号：US14320316
申请日：2014-06-30
申请人： California Institute of Technology , The Regents of the University of California , University of Louisville Research Foundation, Inc.
发明人： Yu-Chong Tai , Mandheerej S. Nandra , Joel W. Burdick , Damien Craig Rodger , Andy Fong , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Igor Lavrov , Susan J. Harkema , Claudia A. Angeli
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0558
摘要： An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.
摘要翻译： 构造成对脊髓施加电刺激的可植入电极阵列组件。 装置的基本上不导电的层具有可包括多个第一开口的脊髓旁边定位的第一部分。 该层具有包括多个第二开口的第二部分。 电极和迹线位于装置的主体部分的周边部分的内部并且沿着该层。 第一开口中的至少一个邻近每个电极，以提供电极可以通过该通路向脊髓提供电刺激的通路。 第二开口中的至少一个与每个迹线相邻，以提供轨迹可以接收电刺激的路径。 至少一个迹线连接到每个电极并且被配置为将迹线接收的电刺激传导到电极。
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15.发明申请公开(公告)号：US20130310911A1
公开(公告)日：2013-11-21
申请号：US13946338
申请日：2013-07-19
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Yu-Chong Tai , Mandheerej S. Nandra , Joel W. Burdick , Damien Craig Rodger , Andy Fong , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Igor Lavrov , Susan J. Harkema , Claudia A. Angeli
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0558
摘要： An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. The layer has a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.
摘要翻译： 构造成对脊髓施加电刺激的可植入电极阵列组件。 装置的基本上不导电的层具有可包括多个第一开口的脊髓旁边定位的第一部分。 该层具有包括多个第二开口的第二部分。 电极和迹线位于装置的主体部分的周边部分的内部并且沿着该层。 第一开口中的至少一个邻近每个电极，以提供电极可以通过该通路向脊髓提供电刺激的通路。 第二开口中的至少一个与每个迹线相邻，以提供轨迹可以接收电刺激的路径。 至少一个迹线连接到每个电极并且被配置为将迹线接收的电刺激传导到电极。
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16.发明申请公开(公告)号：US20190151499A1
公开(公告)日：2019-05-23
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US11154639B2
公开(公告)日：2021-10-26
申请号：US16222918
申请日：2018-12-17
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC分类号： A61K47/34 , A61L27/18 , A61K35/30 , A61L27/38 , A61K35/545 , A61P27/00 , C12N5/079 , A61L27/34 , A61K9/00 , A61L27/56
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US10188769B2
公开(公告)日：2019-01-29
申请号：US14314994
申请日：2014-06-25
申请人： University of Southern California , California Institute of Technology , The Regents of the University of California
发明人： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US11701504B2
公开(公告)日：2023-07-18
申请号：US17150986
申请日：2021-01-15
发明人： Yu-Chong Tai , Aubrey M. Shapero , Shane S. Shahrestani , Azita Emami , Abhinav Agarwal , Kuang-Ming Shang , Sunghoon Kim , Olajire Idowu , Kurtis I. Auguste
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M2205/3344 , A61M2205/3368 , A61M2205/3523 , A61M2205/50 , A61M2207/00
摘要： A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.
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公开(公告)号：US20210220627A1
公开(公告)日：2021-07-22
申请号：US17150986
申请日：2021-01-15
发明人： Yu-Chong Tai , Aubrey M. Shapero , Shane S. Shahrestani , Azita Emami , Abhinav Agarwal , Kuang-Ming Shang , Sunghoon Kim , Olajire Idowu , Kurtis I. Auguste
IPC分类号： A61M27/00
摘要： A long-lasting, wireless, biocompatible pressure sensor device is integrated within a hydrocephalus shunt, either within the shunt's reservoir/anchor or as an inline or pigtailed connector. When integrated within a typical reservoir, the device can sit within the reservoir's hollow frustum area covered by the resilient silicone dome of the reservoir. When integrated as an inline connector, the device can sit at any point on the peritoneal catheter or ventricular catheter, including between the VP shut's valve and reservoir. The pressure sensor device includes electronics that can be powered wirelessly by a reader held to a patient's scalp, and so no battery may be required. The reader can transmit an ambient, atmospheric pressure reading from outside the skull to the implanted device so that its electronics can calculate a calibrated gauge pressure internally and then relay it to a patient's smart phone.
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